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Hemodynamic effects of moderate increase of the plasma vasopressin level in conscious dogs

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Summary

The influence of moderate increase of the plasma ADH level on aortic and central venous pressures, heart rate, cardiac output, stroke volume, central blood volume, systemic peripheral resistance and plasma volume was examined in conscious dogs. The animals were given 0.75 mU ADH/kg b.w. in single intravenous injection as a priming dose. This was followed by a constant infusion of the hormone at a rate of 0,12 mU/min/kg/0.2 ml 0.9% NaCl solution lasting one hour. Plasma ADH level measured at 30 min of the infusion was equal to 22 ± 4 μU/ml. A significant increase of aortic (mean systolic and diastolic) and central venous pressures, systemic peripheral resistance and of plasma volume was observed in the course of the infusion. It was accompanied by a decrease of heart rate, cardiac output and central blood volume. Changes of stroke volume were not significant.

As the plasma level produced by the infusion was such as that following a moderate nonhypotensive haemorrhage [30], the rôle of the hemodynamic effects of vasopressin in maintenance of the blood pressure and volume in hypovolemia is discussed.

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References

  1. Barer, G. R.: A comparison of the circulatory effects of angiotensin, vasopressin and adrenaline in the anesthetized cats. J. Physiol. (Lond.)156, 49 (1961).

    Google Scholar 

  2. Bartelstone, H. J., Nasmyth, P. A.: Vasopressin potentiation of catecholamine action in dog, rat, cat and rat aortic strip. Amer. J. Physiol.208, 754 (1965).

    Google Scholar 

  3. Berde, B., Weidmann, H., Cerletti, A.: Über Phenylalanin2-Lysin-Vasopressin. Helv. physiol. pharmacol. Acta19, 285 (1961).

    Google Scholar 

  4. Betz, E., Niesel, W., Schmahl, F. W., Schmidt, K.: Lokale Durchblutung und capilläre Sauerstoffsättigung des Myokards unter Hypoxie und Hyperkapnie sowie nach Einwirkung von Adrenalin, Noradrenalin und Vasopressin. Pflügers Arch. ges. Physiol.285, 55 (1965).

    Google Scholar 

  5. Bonjour, J. Ph., Malvin, R. L.: Plasma concentrations of ADH in conscious and anaesthetized dogs. Amer. J. Physiol.218, 1128 (1970).

    Google Scholar 

  6. Carlier, J., Lejeune-Ledant, Barac, G.: Effets hémodynamiques comparés d'une vasopressine synthétique et de la pitressine chez le chien. Arch. int. Pharmacodyn.125, 287 (1960).

    Google Scholar 

  7. Czaczkes, J. W., Kleeman, C. R., Koenig, M.: Physiological studies of antidiuretic hormone by its direct measurement in human plasma. J. clin. Invest.43, 1625 (1964).

    Google Scholar 

  8. Drapanas, T., Crowe, C. P., Shim, W. K. T., Schenk, W. G., Jr.: The effect of pitressin on cardiac output and coronary, hepatic and intestinal blood flow. Surg. Gynec. Obstet.113, 484 (1961).

    Google Scholar 

  9. Emerson, T. E., Jr.: Effects of angiotensin, epinephrine, norepinephrine and vasopressin on venous return. Amer. J. Physiol.210, 933 (1966).

    Google Scholar 

  10. Ericsson, B. F.: Hemodynamic effects of vasopressin Acta chir. scand., Suppl. 414 (1971).

  11. Frieden, J., Keller, A. D.: Decreased resistance to haemorrhage in neurohypophysectomised dogs. Circulat. Res.2, 214 (1954).

    Google Scholar 

  12. Friedman, S. M., Pauls, H.: The effect of pitressin infusion on blood pressure of the rabbit, cat and rat. Amer. Heart J.44, 131 (1952).

    Google Scholar 

  13. Gauer, O. H., Tata, P. S.: Vasopressin studies in the rat. II. The amount of water reabsorbed by the rat kidney after a single i.v. injection of vasopressin. The vasopressin water equivalent. Pflügers Arch. ges. Physiol.290, 286 (1966).

    Google Scholar 

  14. Ginsburg, M., Brown, L. M.: Effect of anesthetics and haemorrhage on the release of neurophysial antidiuretic hormone. Brit. J. Pharmacol.14, 327 (1956).

    Google Scholar 

  15. Hamilton, W. F., Moore, J. W., Kinsman, J. M., Spurling, R. G.: Amer. J. Physiol.99, 534 (1932). In: S. Chien and M. J. Gregersen: Determination of body fluid volume. In: Physical techniques in biological research, p. 45. W. L. Nastuk (ed.). New York-London: Academic Press 1962.

    Google Scholar 

  16. Heimburger, J., Teramoto, S., Schumacker, H. B., Jr.: Effect of surgical pituitrin upon portal and hepatic circulation. Surgery48, 706 (1960).

    Google Scholar 

  17. Henry, J. P., Gupta, P. D., Meehan, J. P., Sinclair, R., Share, L.: The role of afferents from the low pressure system in the release of antidiuretic hormone during nonhypotensive haemorrhage. Canad. J. Physiol.46, 287 (1968).

    Google Scholar 

  18. Hume, D. M.: Conference on shock. Fed. Proc.20, 87 (1961).

    Google Scholar 

  19. Johnson, J. A., Zehr, J. E., Moore, W. W.: Effects of separate and concurrent osmotic and volume stimuli on plasma ADH in sheep. Amer. J. Physiol.218, 1273 (1970).

    Google Scholar 

  20. Jong, W., De, McLeod, St. M.: Effect of autonomic blocking agents on the cardiovascular effects of Octapressin in the rat. Europ. J. Pharmacol.1, 93 (1967).

    Google Scholar 

  21. Kozlowski, S., Szczepańska, E., Drzewiecki, K.: Hormonal influences on osmotic reactivity of the thirst mechanism in dogs. Regional congress of the international union of physiological sciences. Brasov, Rumania 1970, Abstract No 491.

  22. Maxwell, G. M.: The cardiovascular effects of Octapressin. Arch. int. Pharmacodyn.158, 17 (1965).

    Google Scholar 

  23. Mazzia, V. D. B., McKenna, J. M., Gyure, L.: Influence of a synthetic analogue of vasopressin on the microcirculation and on survival in shock. Fed. Proc.23, 539 (1964).

    Google Scholar 

  24. McNeil, J. R., Stark, R. D., Greenway, C. V.: Intestinal vasoconstriction after haemorrhage: rôles of vasopressin and angiotensin. Amer. J. Physiol.219, 1342 (1970).

    Google Scholar 

  25. Nash, C. B.: Alteration of vasopressin tachyphylaxis by reserpine pretreatment. Arch. int. Pharmacodyn.155, 90 (1965).

    Google Scholar 

  26. Nash, C. B., Davis, F., Woodbury, R. A.: Cadiovascular effects of anaesthetic doses of pentobarbital sodium. Amer. J. Physiol.185, 107 (1956).

    Google Scholar 

  27. Öberg, B.: Effects of cardiovascular reflexes on net capillary fluid transfer. Acta physiol. scand., Suppl.229 (1964).

  28. Priano, L. L., Traber, D. L., Wilson, R. D.: Barbiturate anasethesia: An abnormal physiologic situation. J. Pharmacol. exp. Ther.165, 126 (1969).

    Google Scholar 

  29. Rocha y Silva, M., Rosenberg, M.: The release of vasopressin in response to haemorrhage and its rôle in the mechanism of blood pressure regulation. J. Physiol. (Lond.)202, 535 (1969).

    Google Scholar 

  30. Szczepańska-Sadowska, E.: The activity of the hypothalamo-hypophysial antidiuretic system in conscious dogs. I. The influence of isoosmotic blood volume changes. Pflügers Arch.335, 139 (1972).

    Google Scholar 

  31. Szczepańska-Sadowska, E.: Plasma ADH level and body water balance in dogs after moderate haemorrhage. To be published in Bull. Acad. pol. Sci. (Cl. 2) (1972).

  32. Szczepańska-Sadowska, E., Sadowski, B.: Antidiuretic assay for vasopressin. To be published in Acta physiol. pol. (1972).

  33. Thorn, N. A.: Mammalian antidiuretic hormone. Physiol. Rev.38, 169 (1958).

    Google Scholar 

  34. Tsakiris, A., Bühlmann, A.: Kreislaufwirkungen eines neuen synthetischen Vasopressins. Experimentelle Untersuchungen mit (2-Phenylalanin-8-Lysin) Vasopressin. Dtsch. med. Wschr.88, 46 (1963).

    Google Scholar 

  35. Wagner, H. N., Braunwald, E.: The pressor effect of the antidiuretic principle of the posterior pituitary in orthostatic hypotension. J. clin. Invest.35, 1412 (1956).

    Google Scholar 

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  1. Department of Applied Physiology, Medical School, Warsaw

    Ewa Szczepańska-Sadowska

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Szczepańska-Sadowska, E. Hemodynamic effects of moderate increase of the plasma vasopressin level in conscious dogs. Pflugers Arch. 338, 313–322 (1973). https://doi.org/10.1007/BF00586073

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