Summary
The authors report on the ultrastructural study of a muscle biopsy carried out in a child 6 years after the first biopsy which had led to diagnosis of “multicore disease”. Clinical evolution following a few years of muscular involvement had been favorable.
The lesions observed in the second biopsy were again characterized by the presence of multicores, but in addition to cores and rods. All of these abnormalities could sometimes be noted in a single muscle fiber. Although rare cases of an association of two types of lesions have been reported, no study has hitherto shown multicores, cores, and rods in the same biopsy. This observation might confirm the possibility of common pathogenic mechanisms producing these lesions.
References
Afifi AK, Smith JW, Zellweger H (1965) Congenital nonprogressive myopathy: central core disease and nemaline myopathy in one family. Neurology 15:371–381
Bethlem J, Arts WF, Dingemans KP (1978) Common origin of rods, miniature cores and focal loss of cross-striation. Arch Neurol 35:555–566
Danon MJ, Giometti CS, Manaligod JR, Perurena OH, Skosey JL (1981) Adult-onset nemaline rods in a patient treated for suspected dermatomyositis. Study with two-dimensional electrophoresis. Arch Neurol 38:761–766
Dubowitz V (1980) The floppy infant. In: Simep (ed) Clinics in developmental medicine no. 76 2 nd edn. Heinemann, London; Lippincott, Philadelphia
Engel AG, Gomez MR Groover RV (1971) Multicore disease. A recently recognized congenital myopathy associated with multifocal degeneration of muscle fibers. Mayo Clin Proc 46: 666–681
Hülsmann N, Gullota F, Okur H (1981) Cytopathology of an unusual case of centronuclear myopathy. Light- and electron-microscopic investigations. J Neurol Sci 50:311–333
Isaacs H, Heffron JJA, Badenhorst M (1975) Central core disease: a correlated, genetic, histochemical, ultramicroscopic and biochemical study. J Neurol Neurosurg Psychiatry 38: 1177–1186
Karpati G, Carpenter S, Andermann F (1971) A new concept of childhood nemaline myopathy. Arch Neurol 24:291–304
Kornfeld M (1980) Mixed nemaline-mitochondrial myopathy. Acta Neuropathol (Berl) 51:185–189
Lee YS, Yip WL (1981) A fatal congenital myopathy with severe type I fibre atrophy, central nuclei and multicores. J Neurol Sci 50:277–290
Lumley de L, Vallat JM, Catanzano G (1976) Etude clinique et ultrastructurale d'un cas de myopathie congénitale à foyers multiples. Ann Pédiat 23:733–736
Neville HE, Brooke MH (1973) Central core fibers: structured and unstructured. In: Kakulas BA (ed) Basic research in myology. Proceedings of the second international congress on muscle diseases part 1. Excerpta Medica, Amsterdam, pp 497–511
Shafiq SA, Gorychi MA, Asiedu SA, Milhorat AT (1969) Tenotomy. Effect on the fine structure of the soleus of the rat. Arch Neurol 20:625–633
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Vallat, J.M., de Lumley, L., Loubet, A. et al. Coexistence of minicores, cores, and rods in the same muscle biopsy. Acta Neuropathol 58, 229–232 (1982). https://doi.org/10.1007/BF00690806
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DOI: https://doi.org/10.1007/BF00690806