Abstract
We have studied the clinical utility of indium 111 autologous leucocyte scintigraphy retrospectively in 45 patients presenting with suspected intra-abdominal sepsis. The sensitivity was 95% (21/22) and the specificity was 91% (21/23). Some 34 of the studies (17 positive and 17 negative) were considered helpful in furthering patient management (76%) and 8, unhelpful (18%). In 3, the study results were misleading and led to inappropriate treatment. Indium 111 scintigraphy, whether positive or negative, provides information in patients with suspected Intra-abdominal sepsis upon which therapeutic decisions can be based.
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Anderson JR, Spence RAJ, Laird JD, Ferguson WF, Kennedy TL (1983) Initial experience with indium-111 autologous leucocyte imaging in patients with acute pancreatitis. Br Med J 287:637–638
Anderson JR, Spence RAJ, Laird JD, Ferguson WR, Kennedy TL (1986) Indium-111 autologous leukocyte imaging in pancreatitis. J Nucl Med 27:345–352
Anstall HB, Coleman RE (1982) Donor-leukocyte imaging in granulocytopenic patients with suspected abscesses: concise communication. J Nucl Med 23:319–321
Ascher NL, Forstrom L, Simmons RL (1980) Radio-labeled autologous leukocyte scanning in abscess detection. World J Surg 4:395–402
Bydder GM, Kreel L (1980) Computed tomography in the diagnosis of abdominal abscess. CT 4:132–145
Carrol B, Silverman PM, Goodwin DA, McDougall IR (1981) Ultrasonography and indium-111 white blood cell scanning for the detection of intra-abdominal abscesses. Radiology 140:155–160
Dutcher JP, Schiffer CA, Johnston GS (1981) Rapid migration of 111-indium-labeled granulocytes to sites of infection. N Engl J Med 304:586–589
Ebright JR, Soin JS, Manoli RS (1982) The gallium scan: problems and misuse in examination of patients with suspected infection. Arch Intern Med 142:246–254
Gordon I, Vivian G (1984) Radio-labelled leucocytes: a new diagnostic tool in occult infection/inflammation. Arch Dis Child 59:62–66
Halliday P, Halliday JH (1976) Subphrenic abscess: a study of 241 patients at the Royal Prince Edward Hospital 1950–1973. Br J Surg 63:352–366
Knochel JQ, Koehler PR, Lee TG, Welch DM (1980) Diagnosis of abdominal abscesses with computed tomography, ultrasound and 111-In leucocyte scans. Radiology 137:425–432
Levitt RG, Biello DR, Sagel SS, Stanley RJ, Aronberg DJ, Robinson ML, Siegel BA (1979) Computed tomography and 67Ga citrate radionuclide imaging for evaluating suspected abdominal abscess. AJR 132:529–534
McAfee JG, Samin A (1985) In-111 labeled leukocytes: a review of problems in image interpretation. Radiology 155:221–229
McDougall IR, Baumert JE, Lantieri RI (1979) Evaluation of 111-indium leukocyte whole body scanning. AJR 133:849–854
Peters AM, Karimjee S, Saverymuttu SH, Lavender JP (1982) A comparison of indium- 111-oxine and indium- 111-acetylacetone labelled leucocytes in the diagnosis of inflammatory disease. Br J Radiol 55:827–832
Roddie ME, Peters AM, Danpure HJ et al. (1988) Inflammation: imaging with Tc-99m HMPAO-labeled leukocytes. Radiology 166:767–772
Rovekamp MH, van Royen EA, Folmer SC, van der Schoot JB (1983) Diagnosis of upper-abdominal infections by In-111 labeled leukocytes with Tc-99m colloid subtraction technique. J Nucl Med 24:212–216
Seabold JE, Wilson DG, Lieberman LM, Boyd CM (1984) Unsuspected extra-abdominal sites of infection: scintigraphic detection with indium-111 labeled leukocytes. Radiology 151:213–217
Segal AW, Arnot RW, Thakur ML, Lavender JP (1976) Indium-111 labelled leucocytes for localisation of abscesses. Lancet 11:1056–1058
Taylor KH, Wasson JF, De Graaff C, Rosenfield AT, Andriole VT (1978) Accuracy of grey-scale ultrasound diagnosis of abdominal and pelvic abscesses in 220 patients. Lancet 1:83–84
Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW (1977) Indium-111-labeled autologous leukocytes in man. J Nucl Med 18:1014–1021
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Baba, A.A., McKillop, J.H., Cuthbert, G.F. et al. Indium 111 leucocyte scintigraphy in abdominal sepsis Do the results affect management?. Eur J Nucl Med 16, 307–309 (1990). https://doi.org/10.1007/BF00842785
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DOI: https://doi.org/10.1007/BF00842785