Abstract
Sixteen children (11 male, 5 female) who developed renal venous thrombosis in the neonatal period or early infancy have been followed for periods varying from 29 months to 16 years (median 12 years) after initial diagnosis. Twelve patients presented with a hyperosmolar state, and in 4 the ilness was preceded by severe birth asphyxia. The diagnosis was based on the findings of clinical and/or radiological renal enlargement (15 cases), haematuria (16 cases) and elevation in plasma urea (16 cases). Thrombocytopenia (13 cases), red cell fragmentation (13 cases) and oliguria (13 cases) were frequent associated findings. All 16 patients survived the acute illness, 1 patient died 3 years later from an unrelated event. On follow-up evaluation, 11 patients have normal renal function (glomerular filtration rate >80 ml/min per 1.73 m2), 5 developed hypertension, 2 of whom responded to unilateral nephrectomy. Urinary concentrating capacity was subnormal (<800 mosmol/kg) in 7 of the 15 cases studied. Follow-up renal imaging studies were undertaken in 14 patients, and the imaging procedure was normal in only 2 of these. Of the remainder, 8 showed unilateral abnormality and 4 bilateral abnormality. Intellectual development was normal in 12 patients, mildly impaired in 1, and severely impaired in 3.
Similar content being viewed by others
References
Arneil GC (1978) Renal venous obstruction. In: Edelmann CM (ed) Pediatric kidney disease. Little Brown, Boston, pp 1098–1104
Arniel GC, McDonald AM, Murphy AV, Sweet EM (1973) Renal venous thrombosis. Clin Nephrol 1:119–131
McFarland JB (1965) Renal venous thrombosis in children. J Med 34:269–290
Oliver WJ, Kelsch RC (1982) Renal venous thrombosis in infancy. Pediatr Rev 4:61
Colan S, Fujii A, Borow K, McPherson D, Sanders S (1983) Noninvasive determination of systolic, diastolic and end-systolic blood pressure in neonates, infants and young children: comparison with central aortic pressure measurements. Am J Cardiol 52:867–875
Report of the Second Task Force on Blood Pressure Control in Children (1987) J Pediatr 79:1–25
Olson D (1976) Renal vein thrombosis in infancy. In: Lieberman E (ed) Clinical pediatric nephrology. Lippincott, Philadelphia, pp 372–380
Rasoulpour M, McLean RH (1980) Renal venous thrombosis in neonates: initial and follow-up abnormalities: Am J Dis Child 134: 276–279
Jobin J, O'Regan S, Demay G, Mongeau JG, Robitaille P (1982) Neonatal renal vein thrombosis. Long-term follow-up after conservative management. Clin Nephrol 17:36–40
Brenner BM, Meyer TW, Hostetter TH (1982) Dietary protein intake and the progressive nature of kidney disease. N Engl J Med 307: 652–659
Goldraich NP, Ranmos OL, Goldraich IH (1989) Urography versus DMSA scan in children with vesicoureteric reflux. Pediatr Nephrol 3:1–5
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mocan, H., Beattie, T.J. & Murphy, A.V. Renal venous thrombosis in infancy: Long-term follow-up. Pediatr Nephrol 5, 45–49 (1991). https://doi.org/10.1007/BF00852843
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00852843