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Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome

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Abstract

A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kidney biopsy. Subsequent episodes showed normal histology by light microscopy and epithelial foot process fusion on electron microscopy, consistent with minimal change nephrotic syndrome. Serum analysis for soluble immune response suppressor was negative pre-nephrectomy, positive during each bout of nephrotic syndrome, and negative during each remission. This case represent de novo occurrence of steroid-sensitive minimal change nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. We stress the need for histological examination of the renal allograft to diagnose rejection, recurrent disease, or de novo disease.

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Authors and Affiliations

  1. Division of Pediatric Nephrology at University of Minnesota Hospitals, 515 Delaware St. SE, Box 491, 55455, Minneapolis, Minnesota, USA

    Pascale H. Lane & Robert L. Vernier

  2. Division of Pediatric Nephrology at Children's Hospital, Washington University, St. Louis, Missouri, USA

    H. William Schnaper

  3. Cardinal Glennon Children's Hospital, St. Louis University, St. Louis University, St. Louis, Missouri, USA

    Timothy E. Bunchman

Authors
  1. Pascale H. Lane
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  2. H. William Schnaper
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  3. Robert L. Vernier
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  4. Timothy E. Bunchman
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Lane, P.H., Schnaper, H.W., Vernier, R.L. et al. Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. Pediatr Nephrol 5, 300–303 (1991). https://doi.org/10.1007/BF00867484

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  • DOI: https://doi.org/10.1007/BF00867484

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