Skip to main content
SpringerLink
Log in

Argon laser panretinal photocoagulation in ischemic central retinal vein occlusion

A 10-year prospective study

  • Clinical Investigations
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

We conducted a prospective, planned study of argon laser panretinal photocoagulation (PRP) in ischemic central retinal vein occlusion (CRVO) over a 10-year period in 123 eyes. On comparing the lasered eyes versus the nonlasered eyes, there was no statistically significant difference between the two groups in the incidence of development of angle neovascularization (NV), neovascular glaucoma (NVG), retinal and/or optic disc NV, or vitreous hemorrhage, or in visual acuity. Our study, however, did show a statistically significant (P= 0.04) difference in the incidence of iris NV between the two groups, with iris NV less prevalent in the laser group than in the nonlaser group, butonly when the PRP was performed within 90 days after the onset of CRVO. The other parameter which showed a statistically significant difference between the two groups was the peripheral visual fields — the laser group suffered a significantly (P≤0.03) greater loss than the non-laser group. We discuss the implications of these findings in light of the natural history of ischemic CRVO and of ocular NV. Since the original rationale for advocating PRP in ischemic CRVO was the proven beneficial effect of PRP on ocular NV in proliferative diabetic retinopathy, we also discuss the disparities in the disease process between ischemic CRVO and proliferative diabetic retinopathy and in their responses to PRP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Coscas G, Dhermy P (1978) Occlusions veineuses rétiniennes. Soc Fr Ophtalmol. Masson, Paris, pp 432–435

    Google Scholar 

  2. Diabetic Retinopathy Study Research Group (1976) Preliminary report on effects of photocoagulation therapy. Am J Ophthalmol 81:383–396

    Google Scholar 

  3. François J, Cambic E, De Laey JJ (1974) Argon laser slitlamp photocoagulation. Indications and results. Ophthalmologica 169:362–370

    PubMed  Google Scholar 

  4. Freyler H, Nichorlis St (1974) Lichtkoagulation bei retinalen Venenthrombosen. Klin Monatsbl Augenheilkd 165:750–755

    PubMed  Google Scholar 

  5. Hayreh SS (1980) Central retinal vein occlusion. In: Mausolf F (ed) The eye and systemic disease. Mosby, St. Louis, pp 223–275

    Google Scholar 

  6. Hayreh SS (1983) Classification of central retinal vein occlusion. Ophthalmology 90:458–474

    PubMed  Google Scholar 

  7. Hayreh SS, Rojas P, Podhajsky P, Montague P, Woolson RF (1983) Ocular neovascularization with retinal vascular occlusion, III. Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology 90:488–506

    PubMed  Google Scholar 

  8. Hayreh SS, Woolson RF, Kohler JA (1981) A procedure for the computer coding of visual fields. Doc Ophthalmol Proc Ser 26:381–388

    Google Scholar 

  9. Hayreh SS, Klugman MR, Beri M, Kimura A, Podhajsky P (1990) Differentiation of ischemic from non-ischemic central retinal vein occlusion during the early acute phase. Graefe's Arch Clin Exp Ophthalmol 228:201–217

    Google Scholar 

  10. Hayreh SS, Klugman MR, Podhajsky P, Kolder HE (1990) Electroretinography in central retinal vein occlusion: correlation of electroretinographic changes with pupillary abnormalities. Graefe's Arch Clin Exp Ophthalmol 227:549–561

    Google Scholar 

  11. Kalbfleisch JD, Prentice RL (1980) The statistical analysis of failure time data. Wiley, New York

    Google Scholar 

  12. Laatikainen L (1977) Preliminary report on effect of retinal panphotocoagulation on rubeosis iridis and neovascular glaucoma. Br J Ophthalmol 61:278–284

    PubMed  Google Scholar 

  13. Laatikainen L (1977) Photocoagulation in retinal venous occlusion. Acta Ophthalmol 55:478–488

    Google Scholar 

  14. Laatikainen L (1983) A prospective follow-up study of panretinal photocoagulation in preventing neovascular glaucoma following ischaemic central retinal vein occlusion. Graefe's Arch Clin Exp Ophthalmol 220:236–239

    Google Scholar 

  15. Laatikainen L, Kohner EM, Khoury D, Blach RK (1977) Panretinal photocoagulation in central retinal vein occlusion: a randomised controlled clinical study. Br J Ophthalmol 61:741–753

    PubMed  Google Scholar 

  16. Magargal LE, Brown GC, Augsburger JJ, Parrish RK (1981) Neovascular glaucoma following central retinal vein obstruction. Ophthalmology 88:1095–1101

    PubMed  Google Scholar 

  17. Magargal LE, Brown GC, Augsburger JJ, Donoso LA (1982) Efficacy of panretinal photocoagulation in preventing neovascular glaucoma following ischemic central retinal vein obstruction. Ophthalmology 89:780–784

    PubMed  Google Scholar 

  18. May DR, Klein ML, Peyman GA (1976) A prospective study of xenon arc photocoagulation for central retinal vein occlusion. Br J Ophthalmol 60:816–818

    PubMed  Google Scholar 

  19. May DR, Klein ML, Peyman GA, Raichand M (1979) Xenon are panretinal photocoagulation for central retinal vein occlusion: a randomised prospective study. Br J Ophthalmol 63:725–734

    PubMed  Google Scholar 

  20. Oosterhuis JA, Sedney SC (1975) Photocoagulation in retinal vein thrombosis. Ophthalmologica 171:365–379

    PubMed  Google Scholar 

  21. Riaskoff S (1978) Le role préventif de la photocoagulation rétinienne dans le développement du glaucome néo-vasculaire après occlusion de la veine centrale de la rétine. Bull Mem Soc Fr Ophthalmol 90:87–90

    Google Scholar 

  22. Saraux H, Offret H, Nou B (1979) Traitement des complications des thromboses veineuses rétiniennes par le laser à l'argon. Mod Probl Ophthalmol 20: 425–428

    PubMed  Google Scholar 

  23. Sedney SC (1976) Photocoagulation in retinal vein occlusion. Junk, The Hague

    Google Scholar 

  24. Servais GE, Thompson HS, Hayreh SS (1986) Relative afferent pupillary defect in central retinal vein occlusion. Ophthalmology 93:301–303

    PubMed  Google Scholar 

  25. Tasman W, Magargal LE, Augsburger JJ (1980) Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. Ophthalmology 87:400–402

    PubMed  Google Scholar 

  26. Theodossiadis G, Charamis J, Velissaropoulos P (1974) Behandlungsergebnisse der Lichtkoagulation bei Ast- und Zentralvenenverschluss. Klin Monatsbl Augenheilkd 164:713–721

    PubMed  Google Scholar 

  27. Trost DC, Woolson RF, Hayreh SS (1979) Quantification of visual fields for statistical analysis. Arch Ophthalmol 97:2175–2180

    PubMed  Google Scholar 

  28. Verdaguer J, Lechuga M, Le Clerq N (1979) Photocoagulation in central retinal vein occlusion. Mod Probl Ophthalmol 20:421–424

    PubMed  Google Scholar 

  29. Vidic B, Hiti H, Schuhmann G, Hubel K (1981) Verlauf retinaler Venenthrombosen nach Laserkoagulation. Klin Monatsbl Augenheilkd 179:415–417

    PubMed  Google Scholar 

  30. Wetzig PC, Thatcher DB (1974) The treatment of acute and chronic central venous occlusion by light coagulation. Mod Probl Ophthalmol 12:247–253

    PubMed  Google Scholar 

  31. Woolson RF (1987) Statistical methods for the analysis of biomedical data. Wiley, New York, pp 187–198, 215–226

    Google Scholar 

  32. Zweng HCh, Fahrenbruch RC, Little HL (1974) Argon laser photocoagulation in the treatment of retinal vein occlusions. Mod Probl Ophthalmol 12:261–270

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Iowa, Iowa City, USA

    Sohan Singh Hayreh, Patricia Podhajsky, Gary E. Servais & Edward S. Perkins

  2. Department of Preventive Medicine (Biostatistics), University of Iowa, Iowa City, USA

    Marie R. Klugman

Authors
  1. Sohan Singh Hayreh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie R. Klugman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patricia Podhajsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gary E. Servais
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Edward S. Perkins
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This investigation was supported by grant EY-1151 from the National Institutes of Health, and in part by unrestricted grants from Research to Prevent Blindness, Inc., and from the Alcon Research Institute

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayreh, S.S., Klugman, M.R., Podhajsky, P. et al. Argon laser panretinal photocoagulation in ischemic central retinal vein occlusion. Graefe's Arch Clin Exp Ophthalmol 228, 281–296 (1990). https://doi.org/10.1007/BF00920049

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00920049

Keywords

Search

Navigation