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Influence of genotype and age on noise-induced auditory losses

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Abstract

The mouse was used as a model in order to determine how genetic contributions interact with age, producing genotype-specific patterns of noise-induced auditory losses. Inbred CBA/J, AUS/sJ, and SJL/J mice were exposed to 5 min of a 124-dB octave band (12-to 24-kHz) noise at either 20, 180, or 360 days of age. in all mice, the youngest subjects were most severely affected, and the cochlear loss was most pronounced near the center frequency of the noise exposure (16 kHz). With increasing age, the maximal loss occurred at successively higher frequencies. This agerelated pattern proceeded most rapidly in the CBA/J, and most slowly in the SJL/J, genotype. The AUS/sJ strain was most adversely affected. These findings were discussed with reference to hypotheses relating genotype to susceptibility to noise-produced cochlear damage, and to industrial surveys describing ethnic differences of noise-induced hearing loss.

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References

  • Boggan, W. O., Freedman, D. X., Lavelle, R. A., and Schlesinger, K. (1971). Studies in audiogenic seizure susceptibility.Psychopharmacol. Berl. 20:48–56.

    Google Scholar 

  • Cody, A. R., and Johnstone, B. M. (1981). Acoustic trauma: Single neuron basis for the “half octave shift.”J. Acoust. Soc. Am. 70:707–711.

    Google Scholar 

  • Corso, J. F., Wright, H. N., and Valerio, M. (1976). Auditory temporal summation in presbcusis and noise exposure.J. Gerontol. 31:58–63.

    Google Scholar 

  • Davis, H., Morgan, C. T., Hawkins, J. T., Jr., Galambos, R., and Smith, F. W. (1950). Temporary deafness following exposure to loud tones and noise.Acta Otolaryngol. Suppl. 88:1–57.

    Google Scholar 

  • Deol, M. S. (1981). Mutant mice as models for human genetical deafness.Symp. Zool. Soc. Lond. 47:617–625.

    Google Scholar 

  • Ehret, G. (1976). Development of absolute auditory thresholds in the house mouse (Mus musculus).J. Am. Audiol. Soc. 1:179–184.

    Google Scholar 

  • Hawkins, J. E., Jr., Johnsson, L.-G., Stebbins, W. C., Moody, D. B., and Coombs, S. L. (1976). Hearing loss and cochlear pathology in monkeys after noise exposure.Acta Otolaryngol. 81:337–343.

    Google Scholar 

  • Henry, K. R. (1967). Audiogenic seizure susceptibility induced in C57BL/6J mice by prior auditory exposure.Science 158:938–940.

    Google Scholar 

  • Henry, K. R. (1982a). Aging and audition in the laboratory mouse. In Willott, J. F. (ed.),Auditory Psychobiology of the Mouse, Thomas, Springfield, Ill. (in press).

    Google Scholar 

  • Henry, K. R. (1982b). Age-related auditory loss and genetics: An electrocochleographic comparison of six inbred strains of mice.J. Gerontol. 37:275–282.

    Google Scholar 

  • Henry, K. R. (1982c). Abnormal auditory development resulting from exposure to ototoxic chemicals, noise and auditory restriction. In Romand, R., and Marty, R. (eds.),Development of Auditory and Vestibular Systems, Academic Press, New York (in press).

    Google Scholar 

  • Henry, K. R., and Bowman, R. E. (1970). Behavior-genetic analysis of the ontogeny of acoustically primed audiogenic seizures in mice.J. Comp. Physiol. Psychol. 70:235–241.

    Google Scholar 

  • Henry, K. R., and Chole, R. A. (1980). Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse.Audiology 19:369–383.

    Google Scholar 

  • Henry, K. R., and Lepkowski, C. M. (1978). Evoked potential correlates of genetic progressive hearing loss.Acta Otolaryngol. 86:366–374.

    Google Scholar 

  • Hood, J. D., Poole, J. P., and Freedman, L. (1976) The influence of eye colour upon temporary threshold shift.Audiology 15:449–464.

    Google Scholar 

  • Karsai, L. K., Bergman, M., and Choo, Y. B. (1972). Hearing in ethnically different longshoremen.Arch. Otolaryng. 96:499–504.

    Google Scholar 

  • Maxson, S. C. (1978). Strain differences in the development of susceptibility to audiogenic seizures after priming but not after hearing loss.Exp. Neurol. 62:482–488.

    Google Scholar 

  • McRae, J. H. (1971) Noise-induced hearing loss and presbycusis.Audiology 10:323–333.

    Google Scholar 

  • Mikaelian, D., Alford, B. R., and Ruben, R. J. (1965). Cochlear potentials and VIII nerve action potentials in normal and genetically deaf mice.Ann. Otol. Rhinol. Laryngol. 74:146–157.

    Google Scholar 

  • Paparella, M. M., Hanson, D. G., Rao, K. N., and Ulvstad, R. (1975). Genetic sensorineural deafness in humans.Ann. Otol. Rhinol. Laryngol. 84:459–473.

    Google Scholar 

  • Rose, S. P., Conneally, P. M., and Nance, W. E. (1977). Genetic analysis of childhood deafness. In Bess, F. H. (ed.),Childhood Deafness: Causation, Assessment and Man-agement, Grune and Stratton, New York.

    Google Scholar 

  • Rosen, S., Bergman, M., Plester, D., El-Mofty, A., and Satti, M. H. (1962). Presbycusis study of a relatively noise-free population in the Sudan.Ann. Otol. 71:727–742.

    Google Scholar 

  • Royster, L. H., and Thomas, W. G. (1979). Age effect hearing levels for a white nonindustrial noise exposed population and their use in evaluating industrial hearing conservation programs.J. Am. Ind. Hyg. Assoc. 40:504–511.

    Google Scholar 

  • Royster, L. H., Driscol, D. P., Thomas, W. G., and Royster, J. D. (1980a). Age effect hearing levels for a black nonindustrial noise exposed population.J. Am. Ind. Hyg. Assoc. 41:113–119.

    Google Scholar 

  • Royster, L. H., Royster, J. D., and Thomas, W. G. (1980b). Representative hearing levels by race and sex in North Carolina industry.J. Acoust. Soc. Am. 68:551–566.

    Google Scholar 

  • Salvi, R. J., Hamernik, R. P., and Henderson, D. (1979a). Auditory nerve activity and cochlear morphology after noise exposure.Arch. Otorhinolaryngol. 224:111–116.

    Google Scholar 

  • Salvi, R. J., Henderson, D., and Hamernik, R. P. (1979b). Single auditory nerve fiber and action potential latencies in normal and noise-treated chinchillas.Hear. Res. 1:237–251.

    Google Scholar 

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This work was supported by Grants 5-R01-AG-01018 from the U.S. National Institute on Aging and 1-R01-NS-17201 from the U.S. National Institute of Neurological and Communicative Diseases and Stroke.

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Henry, K.R. Influence of genotype and age on noise-induced auditory losses. Behav Genet 12, 563–573 (1982). https://doi.org/10.1007/BF01070410

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