Abstract
The mouse was used as a model in order to determine how genetic contributions interact with age, producing genotype-specific patterns of noise-induced auditory losses. Inbred CBA/J, AUS/sJ, and SJL/J mice were exposed to 5 min of a 124-dB octave band (12-to 24-kHz) noise at either 20, 180, or 360 days of age. in all mice, the youngest subjects were most severely affected, and the cochlear loss was most pronounced near the center frequency of the noise exposure (16 kHz). With increasing age, the maximal loss occurred at successively higher frequencies. This agerelated pattern proceeded most rapidly in the CBA/J, and most slowly in the SJL/J, genotype. The AUS/sJ strain was most adversely affected. These findings were discussed with reference to hypotheses relating genotype to susceptibility to noise-produced cochlear damage, and to industrial surveys describing ethnic differences of noise-induced hearing loss.
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This work was supported by Grants 5-R01-AG-01018 from the U.S. National Institute on Aging and 1-R01-NS-17201 from the U.S. National Institute of Neurological and Communicative Diseases and Stroke.
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Henry, K.R. Influence of genotype and age on noise-induced auditory losses. Behav Genet 12, 563–573 (1982). https://doi.org/10.1007/BF01070410
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DOI: https://doi.org/10.1007/BF01070410