Abstract
Penicillium marneffei is endemic in Southeast Asia. Although Thailand is a country in this region, penicillosis marneffei was rare. It was found occasionally in immunocompromised patients. With the increasing incidence of HIV seropositivity penicillosis marneffei emerged as one of the major problems in HIV infected patients residing in Thailand. The common presenting signs were fever, anemia, hepatomegaly, lymphadenopathy, productive cough and a common skin manifestation as molluscum contagiosum-like lesions. The diseases should be considered in Thais and immunocompromised travelers with a history of visiting Thailand. Because the disease is potentially curable, prompt diagnosis and treatment will lead to better prognosis.
Similar content being viewed by others
References
Imwidthaya P. One year's experience withCryptococcus neoformans in Thailand. Trans Roy Soc Trop Hyg 1994; 88: 208.
Capponi PM, Sureau P, Segretain G. Penicillose deRhizomys sinensis. Bull Soc Pathol Exot 1956; 49: 418–21.
Segretain G. Description d'une nouvelle espece dePenicillium: Penicillium marneffei, n.sp. Bull Soc Mycol Fr 1959; 75: 412–16.
Segretain G.Penicillium marneffei, n.sp., agent d'une mycose du système reticulo-endothelial. Mycopathol Mycol Appl 1959; 11: 327–53.
DiSalvo AF, Fickling AM, Ajello L. Infection caused byPenicillium marneffei: Description of first natural infection in man. Am J Clin Pathol 1973; 60: 259–63.
Pautler KB, Padhye AA, Ajello L. Imported penicillosis marneffei in the United States: Report of a second human infection. Sabouraudia 1984; 22: 433–8.
Jayametra P, Nitiyanant P, Ajello L, Padhye AA, Lolekha S, Atichartakarn U, Vathesatogit P, Sathaphatayavongs B, Prajaktam R. Penicillosis marneffei in Thailand: Report of five human cases. Am J Trop Med Hyg 1984; 33: 637–44.
Deng Z, Connor DH. Progressive disseminated penicillosis caused byPenicillium marneffei. Am J Clin Pathol 1985; 84: 323–7.
Centers for Disease Control. AIDS task force update on acquired immune deficiency syndrome (AIDS): United States. MMWR 1982; 31: 507–14.
Piehl MR, Kaplan RL, Haber MH. Disseminated penicillosis in a patient with acquired immunodeficiency syndromes. Arch Pathol Lab Med 1988; 112: 1262–4.
Sathapatayavongs B, Damrongkitchaiporn S, Saengditha P, Kiatboonsri S, Jayanetra P. Disseminated penicillosis marneffei associated with HIV infection. J Infect 1989; 19: 84–5.
Suparatpinyo K, Hirunsri P, Uthammachai C, Chiemchavit S, Baosoung V, Chaimongkol B, Sirisanthana T. An efficacy study of Itraconazole in the treatment ofPenicillium marneffei infection. J Med Assoc Thai 1992; 75: 688–91.
Chiewchavit S, Mahanupab P, Hirunsri P, Vanittanakorn N. Cutaneous manifestations of disseminatedPenicillium marneffei mycosis in five HIV-infected patients. Mycoses 1991; 34: 245–9.
Rico MJ, Penneys NS. Cutaneous cryptococosis resembling molluscum contagiosum in a patient with AIDS. Arch Dermatol 1985; 121: 90.
Supparatpinyo K, Kwangsuksatith C, Hirunsri P, Uthammachai C, Sirisanthana T. Systemic mycosis caused byCryptococcus neoformans, Penicillium marneffei andHistoplasma capsalatum in a patient with acquired immunodeficiency syndrome. J Inf Dis Antimicrob Agents. 1992; 9: 97–9.
Viviani MA, Tortorano AM, Rizzardini G, Quirino T, Kaufman L, Padhye AA, Ajello L. Treatment and serological studies of an Italian case of penicillosis marneffei contracted in Thailand by a drug addict infected with human immunodeficiency virus. Eur J Epidemiol 1993; 9: 979–85.
Centers for Disease Control. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987; 36 (suppl, No. 12), 3S-15S.
Patamasucon P. AIDS in Thailand. J Infect Dis Antimicrob Agents 1992; 9: 35–6.
Deng ZL, Yun M. Ajello L. Human penicillosis marneffei and its relation to the bamboo rat (Rizomys pruinosus). J Med Vet Myc 1986; 24: 383–9.
Sukrungrueng S, personal communications.
Denz Z, Ribas JL, Gibson DW, Conner DH. Infection caused byPenicillium merneffei in China and Southeast Asia: Review of eighteen published cases and report of four more Chinese cases. Rev Infect Dis 1988; 10: 640–52.
Supparatpinyo K, Nelson KE, Merz WG, Breslin BJ, Cooper CR, Kawwan C, Sirisanthana T. Response to antifungal therapy by human immunodeficiency virus-infected patients with disseminatedPenicillium merneffei infections and in vitro susceptibilities of isolates from clinical specimens. Antimicrob Agents Chemother 1993; 37: 2407–11.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Imwidthaya, P. Update of Penicillosis marneffei in Thailand. Mycopathologia 127, 135–137 (1994). https://doi.org/10.1007/BF01102912
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01102912