Skip to main content
Log in

Update of Penicillosis marneffei in Thailand

Review article

  • Human And Animal Mycology
  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

Penicillium marneffei is endemic in Southeast Asia. Although Thailand is a country in this region, penicillosis marneffei was rare. It was found occasionally in immunocompromised patients. With the increasing incidence of HIV seropositivity penicillosis marneffei emerged as one of the major problems in HIV infected patients residing in Thailand. The common presenting signs were fever, anemia, hepatomegaly, lymphadenopathy, productive cough and a common skin manifestation as molluscum contagiosum-like lesions. The diseases should be considered in Thais and immunocompromised travelers with a history of visiting Thailand. Because the disease is potentially curable, prompt diagnosis and treatment will lead to better prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Imwidthaya P. One year's experience withCryptococcus neoformans in Thailand. Trans Roy Soc Trop Hyg 1994; 88: 208.

    Google Scholar 

  2. Capponi PM, Sureau P, Segretain G. Penicillose deRhizomys sinensis. Bull Soc Pathol Exot 1956; 49: 418–21.

    Google Scholar 

  3. Segretain G. Description d'une nouvelle espece dePenicillium: Penicillium marneffei, n.sp. Bull Soc Mycol Fr 1959; 75: 412–16.

    Google Scholar 

  4. Segretain G.Penicillium marneffei, n.sp., agent d'une mycose du système reticulo-endothelial. Mycopathol Mycol Appl 1959; 11: 327–53.

    Google Scholar 

  5. DiSalvo AF, Fickling AM, Ajello L. Infection caused byPenicillium marneffei: Description of first natural infection in man. Am J Clin Pathol 1973; 60: 259–63.

    Google Scholar 

  6. Pautler KB, Padhye AA, Ajello L. Imported penicillosis marneffei in the United States: Report of a second human infection. Sabouraudia 1984; 22: 433–8.

    Google Scholar 

  7. Jayametra P, Nitiyanant P, Ajello L, Padhye AA, Lolekha S, Atichartakarn U, Vathesatogit P, Sathaphatayavongs B, Prajaktam R. Penicillosis marneffei in Thailand: Report of five human cases. Am J Trop Med Hyg 1984; 33: 637–44.

    Google Scholar 

  8. Deng Z, Connor DH. Progressive disseminated penicillosis caused byPenicillium marneffei. Am J Clin Pathol 1985; 84: 323–7.

    Google Scholar 

  9. Centers for Disease Control. AIDS task force update on acquired immune deficiency syndrome (AIDS): United States. MMWR 1982; 31: 507–14.

    Google Scholar 

  10. Piehl MR, Kaplan RL, Haber MH. Disseminated penicillosis in a patient with acquired immunodeficiency syndromes. Arch Pathol Lab Med 1988; 112: 1262–4.

    Google Scholar 

  11. Sathapatayavongs B, Damrongkitchaiporn S, Saengditha P, Kiatboonsri S, Jayanetra P. Disseminated penicillosis marneffei associated with HIV infection. J Infect 1989; 19: 84–5.

    Google Scholar 

  12. Suparatpinyo K, Hirunsri P, Uthammachai C, Chiemchavit S, Baosoung V, Chaimongkol B, Sirisanthana T. An efficacy study of Itraconazole in the treatment ofPenicillium marneffei infection. J Med Assoc Thai 1992; 75: 688–91.

    Google Scholar 

  13. Chiewchavit S, Mahanupab P, Hirunsri P, Vanittanakorn N. Cutaneous manifestations of disseminatedPenicillium marneffei mycosis in five HIV-infected patients. Mycoses 1991; 34: 245–9.

    Google Scholar 

  14. Rico MJ, Penneys NS. Cutaneous cryptococosis resembling molluscum contagiosum in a patient with AIDS. Arch Dermatol 1985; 121: 90.

    Google Scholar 

  15. Supparatpinyo K, Kwangsuksatith C, Hirunsri P, Uthammachai C, Sirisanthana T. Systemic mycosis caused byCryptococcus neoformans, Penicillium marneffei andHistoplasma capsalatum in a patient with acquired immunodeficiency syndrome. J Inf Dis Antimicrob Agents. 1992; 9: 97–9.

    Google Scholar 

  16. Viviani MA, Tortorano AM, Rizzardini G, Quirino T, Kaufman L, Padhye AA, Ajello L. Treatment and serological studies of an Italian case of penicillosis marneffei contracted in Thailand by a drug addict infected with human immunodeficiency virus. Eur J Epidemiol 1993; 9: 979–85.

    Google Scholar 

  17. Centers for Disease Control. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987; 36 (suppl, No. 12), 3S-15S.

    Google Scholar 

  18. Patamasucon P. AIDS in Thailand. J Infect Dis Antimicrob Agents 1992; 9: 35–6.

    Google Scholar 

  19. Deng ZL, Yun M. Ajello L. Human penicillosis marneffei and its relation to the bamboo rat (Rizomys pruinosus). J Med Vet Myc 1986; 24: 383–9.

    Google Scholar 

  20. Sukrungrueng S, personal communications.

  21. Denz Z, Ribas JL, Gibson DW, Conner DH. Infection caused byPenicillium merneffei in China and Southeast Asia: Review of eighteen published cases and report of four more Chinese cases. Rev Infect Dis 1988; 10: 640–52.

    Google Scholar 

  22. Supparatpinyo K, Nelson KE, Merz WG, Breslin BJ, Cooper CR, Kawwan C, Sirisanthana T. Response to antifungal therapy by human immunodeficiency virus-infected patients with disseminatedPenicillium merneffei infections and in vitro susceptibilities of isolates from clinical specimens. Antimicrob Agents Chemother 1993; 37: 2407–11.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Imwidthaya, P. Update of Penicillosis marneffei in Thailand. Mycopathologia 127, 135–137 (1994). https://doi.org/10.1007/BF01102912

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01102912

Key words

Navigation