Summary
The ability of sertindole to influence the ex vivo binding of3H-ketanserin,3H-prazosin and3H-spiperone to 5-HT2 receptors, α1-adrenoceptors and DA D2 receptors, respectively, in rat brain has been studied after acute treatment.
Sertindole is a potent, long acting compound which readily passes the blood-brain barrier. It dose-dependently binds to all three receptors types. In line with in vivo behavioural experiments sertindole has the most pronounced effect on 5-HT2 receptors, lower effect on α1-adrenoceptors and the lowest effect on striatal D2 receptors.
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Hyttel, J., Nielsen, J.B. & Nowak, G. The acute effect of sertindole on brain 5-HT2, D2 and α1 receptors (ex vivo radioreceptor binding studies). J. Neural Transmission 89, 61–69 (1992). https://doi.org/10.1007/BF01245352
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DOI: https://doi.org/10.1007/BF01245352