Abstract
We have measured, by an intubation method, gastric evacuation and gastrointestinal absorption of alcohol ingested with a meal in seven healthy nonalcoholic subjects. A homogenized meal containing [14C]PEG and ethanol (1 g/kg body wt) was given intragastrically while saline containing [57CO]vitamin B12 was perfused into the duodenum. Of the ingested alcohol, 39.4±4.1% was absorbed through the stomach wall during the first postprandial hour and 73.2±4.2% during the total postcibal period, whereas only 24±3% was absorbed during the same time in the duodenum. Thus alcohol ingested with a meal is mainly and rapidly absorbed in the stomach; the contribution of the small intestine below the angle of Treitz to alcohol absorption is negligible.
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References
Nazer H, Wright RA: The effect of alcohol on the human alimentary tract: A review. J Clin Gastroenterol 5:361–365, 1983
Holt S, Stewart MJ, Adam RD, Heading RC: Alcohol absorption, gastric emptying and a breath analyzer. Br J Clin Pharmacol 9:205–208, 1980
Holt S: Observations on the relation between alcohol absorption and the rate of gastric emptying. Can Med Assoc J 124:267–297, 1981
Rees WDW, Go VLW, Malagelada JR: Simultaneous measurement of antroduodenal motility, gastric emptying and duodeno gastric reflux in man. Gut 20:963–970, 1979
Malagelada JR, Longstreth GF, Summerskill WHJ, Go VLW: Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterology 70:203–210, 1976
Atwater WO, Billings JS, Bowditch HP, Chittenden RH, Welch WH:In Physiological Aspects of the Liquor Problem. Vol 1. Austin (ed). Boston, Houghton, Mifflin, 1903, p 143
Grehant N: Recherches sur l'alcool éthylique injecté dans le sang ou dans l'estomac et sur ce qu'il devient dans l'organisme. J Physiol (Paris) 9:978–986, 1907
Cooke AR, Birchall A: Absorption of ethanol from the stomach. Gastroenterology 57:269–272, 1969
Cooke AR: The simultaneous emptying and absorption of ethanol from the human stomach. Am J Dig Dis 15(5): 449–454, 1970
Hillbom ME, Wallgren H: Role of gastric emptying on ethanol poisoning in rats. Med Biol 56:37–41, 1978
Carter EA, Isselbacher KJ: The metabolism of ethanol to carbon dioxide by stomach and small intestine slices. Proc Soc Exp Biol Med 138:817–819, 1971
Lamboeuf Y, De Saint Blanquat G, Derache R: Evaluation of gastric and intestinal catabolism of ethanol in the rat.In Alcohol and the GI Tract. C Stock, H Sarles (eds). Paris, Inserm, 1980, pp 143–150
Pestalozzi DM, Buhler R, von Wartburg JP, Hess M: Immunohistochemical localization of alcohol dehydrogenase in the human gastrointestinal tract. Gastroenterology 85:1011–1016, 1983
Jian R, Modigliani R: Absorption intestinale et alcoolisme chronique chez l'homme. Gastroenterol Clin Biol 4:577–587, 1980
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Cortot, A., Jobin, G., Ducrot, F. et al. Gastric emptying and gastrointestinal absorption of alcohol ingested with a meal. Digest Dis Sci 31, 343–348 (1986). https://doi.org/10.1007/BF01311667
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DOI: https://doi.org/10.1007/BF01311667