Skip to main content
SpringerLink
Log in

Correlation of gastric ulcer healing features by endoscopy, stereoscopic microscopy, and histology, and a reclassification of the epithelial regenerative process

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Four stages of gastric ulcer healing have been established by correlating endoscopic findings with those obtained from stereoscopic microscopy and histologic observations: I. initial healing stage; II. proliferative healing stage; III. palisade scar stage; IV. cobblestone scar stage. The palisade scar and cobblestone scar stages roughly correspond to Sakita's red and white scar stages, respectively. It is suggested that healing is not complete until the cobblestone stage with attendant micropit formation is achieved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Dyck WP, Belsito A, Fleshler B, Leibermann TR, Dickinson PB, Wood JM: Cimetidine and placebo in the treatment of benign gastric ulcer. A multicenter double blind study. Gastroenterology 74:410–415, 1978

    Google Scholar 

  2. Englert E Jr, Freston JW, Graham DY, Finklestein W, Kruss DM, Priest RJ, Raskin JB, Rhodes JB, Rogers AI, Wenger J, Wilcox LL, Crossley RJ: Cimetidine, antacid, and hospitalization in the treatment of benign gastric ulcer. A multicenter double blind study. Gastroenterology 74:416–425, 1978

    Google Scholar 

  3. Scheurer U, Witzel L, Halter F, Keller H-M, Huber R, Galeazzi R: Gastric and duodenal ulcer healing under placebo treatment. Gastroenterology 72:838–841, 1977

    Google Scholar 

  4. Gonoi T, Igarashi T: Problems in diagnosis of gastric ulcer. Saishin Igaku (in Japanese) 21:433–441, 1966

    Google Scholar 

  5. Sakita T, Fukutomi H: Endoscopic diagnosis. In Ulcers of Stomach and Duodenum (in Japanese), Y Yoshitoshi (ed). Tokyo, Nankodo Co., 1971, pp. 197–208

    Google Scholar 

  6. Miyake T, Ariyoshi J, Suzaki T, Oishi M, Sakai M, Ueda S: Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrence rate of gastric ulcers. Dig Dis Sci 25:1–7, 1980

    Google Scholar 

  7. Suzaki T, Miyake T: Dissecting-microscope study of the gastric mucosa: Capillary picture visualized by India ink infusion and gland opening pattern. II. Adenomatous polyp, atypical epithelium and benign ulcer. Gastroenterological Endoscopy (in Japanese) 17(4):532–539, 1975

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Tenri Hospital, 632, Nara, Japan

    Takeo Miyake MD, Takeshi Suzaki MD & Masami Oishi MD

Authors
  1. Takeo Miyake MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeshi Suzaki MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masami Oishi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miyake, T., Suzaki, T. & Oishi, M. Correlation of gastric ulcer healing features by endoscopy, stereoscopic microscopy, and histology, and a reclassification of the epithelial regenerative process. Digest Dis Sci 25, 8–14 (1980). https://doi.org/10.1007/BF01312726

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01312726

Keywords

Search

Navigation