Skip to main content
SpringerLink
Log in

Orocecal transit delay in obese patients

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Orocecal transit time was assessed with lactulose hydrogen breath test in 12 obese patients during intravenous infusion of placebo or naloxone 40 μg/kg/hr given in randomized order and in double-blind conditions. Transit time was also evaluated in 22 healthy controls. Orocecal transit was significantly (P<0.01) longer in the obese patients during placebo treatment (median 130, range 100–200 min) than in the healthy controls (median 75, range 40–170 min). Compared with placebo, transit time in the obese subjects was delayed (P<0.05) during naloxone treatment (median 150, range 100–230 min).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Atkinson RL: Naloxone decreases food intake in obese humans. J Clin Endocrinol Metab 55:196–198, 1982

    PubMed  Google Scholar 

  2. Wolkowitz OM, Doran AR, Cohen MR, Cohen RM, Wise TN, Pickar D: Effects of naloxone on food consumption in obesity. N Engl J Med 313:327, 1985

    Google Scholar 

  3. Atkinson RL, Berke LK, Drake CR, Bibbs ML, Williams FL, Kaiser DL: Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther 38:419–422, 1985

    PubMed  Google Scholar 

  4. Givens JR, Wiedemann E, Andersen RN, Kitabchi AE: β-endorphin and β-lipotropin plasma levels in hirsute women: Correlation with body weight. J Clin Endocrinol Metab 50:975–976, 1980

    PubMed  Google Scholar 

  5. Genazzani AR, Facchinetti F, Petraglia F, Pintor C, Corda R: Hyperendorphinemia in obese children and adolescents. J Clin Endocrinol Metab 62:36–40, 1986

    PubMed  Google Scholar 

  6. Sninsky CA, Davis RH, Clench MH, Thomas KD, Mathias JR: Effect of lidamidine hydrochloride and loperamide on gastric emptying and transit of the small intestine. A doubleblind study. Gastroenterology 90:68–73, 1986

    PubMed  Google Scholar 

  7. Basilisco G, Bozzani A, Camboni G, Recchia M, Quatrini M, Conte D, Penagini R, Bianchi PA: Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test. Gut 26:700–703, 1985

    PubMed  Google Scholar 

  8. Basilisco G, Camboni G, Bozzani A, Paravicini M, Bianchi PA: Oral naloxone antagonizes loperamide-induced delay of orocecal transit. Dig Dis Sci 32:829–832, 1987

    PubMed  Google Scholar 

  9. Metz G, Gassul MA, Leeds AR, Blendis LM, Jenkis DJA: A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling. Clin Sci Mol Med 50:237–240, 1976

    PubMed  Google Scholar 

  10. Zuccato E, Andreoletti M, Bozzani A, Marcucci F, Velio P, Bianchi PA: Respiratory excretion of hydrogen and methane in Italian subjects after ingestion of lactose and milk. Eur J Clin Invest 13:261–266, 1983

    PubMed  Google Scholar 

  11. Lentner C (ed): Geigy Scientific Tables. Basle, Ciba-Geigy Limited, 1984, 3, p 326

    Google Scholar 

  12. Horowitz M, Collins PJ, Cook DJ, Harding PE, Shearman DJC: Abnormalities of gastric emptying in obese patients. Int J Obesity 7:415–421, 1983

    Google Scholar 

  13. Horowitz M, Collins PJ, Tuckwell V, Vernon-Roberts J, Shearman DJC: Fenfluramine delays gastric emptying of solid food. Br J Clin Pharmacol 19:849–851, 1985

    PubMed  Google Scholar 

  14. Wright RA, Krinsky S, Fleeman C, Trujillo J, Teague E: Gastric emptying and obesity. Gastroenterology 84:747–751, 1983

    PubMed  Google Scholar 

  15. Sasaki H, Nagulesparan M, Dubois A, Straus E, Samloff IM, Lawrence WH, Johnson GC, Sievers ML, Unger RH: Hypergastrinemia in obese noninsulin-dependent diabetes: A possible reflection of high prevalence of vagal dysfunction. J Clin Endocrinol Metab 56:744–750, 1983

    PubMed  Google Scholar 

  16. Campbell IW, Heading C, Tothill P, Buist TAS, Ewing DJ, Clarke BF: Gastric emptying in diabetic autonomic neuropathy. Gut 18:462–467, 1977

    PubMed  Google Scholar 

  17. Snape WJ Jr, Battle WM, Schwartz SS, Braunstein SN, Goldstein HA, Alavi A: Metoclopramide to treat gastroparesis due to diabetes mellitus. A double-blind, controlled trial. Ann Intern Med 96:444–446, 1982

    PubMed  Google Scholar 

  18. Sasaki H, Nagulesparan M, Dubois A, Vasquez B, Johnson GC, Sievers ML, Unger RH: Hyperinsulinemia in obesity: Lack of relation to gastric emptying of glucose solution or to plasma somatostatin levels. Metabolism 32:701–705, 1983

    PubMed  Google Scholar 

  19. Sasaki H, Nagulesparan M, Dubois A, Samloff IM, Straus E, Sievers ML, Unger RH: Gastric function and obesity: Gastric emptying, gastric acid secretion and plasma pepsinogen. Int J Obesity 8:183–190, 1984

    Google Scholar 

  20. Borody TJ, Quigley EMM, Phillips SF, Wienbeck M, Tucker RL, Haddad A, Zinsmeister AR: Effects of morphine and atropine on motility and transit in the human ileum. Gastroenterology 89:562–570, 1985

    PubMed  Google Scholar 

  21. Feldman M, Walsh JH, Taylor IL: Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polipeptide concentrations in humans. Gastroenterology 79:294–298, 1980

    PubMed  Google Scholar 

  22. Mittal RK, Frank EB, Lange RC, McCallum RW: Effects of morphine and naloxone on esophageal motility and gastric emptying in man. Dig Dis Sci 31:936–942, 1986

    PubMed  Google Scholar 

  23. Camilleri M, Malagelada JR, Stanghellini V, Zinsmeister AR, Kao PC, Li CH: Dose related effects of synthetic human β-endorphin and naloxone on fed gastrointestinal motility. Am J Physiol 251:G147-G154, 1986

    PubMed  Google Scholar 

  24. Kinsman RI, Read NW: Effect of naloxone on feedback regulation of small bowel transit by fat. Gastroenterology 87:335–337, 1984

    PubMed  Google Scholar 

  25. Morley JE, Levine AS, Yamada T, Gebhard RL, Prigge WF, Shafer RB, Goetz FC, Silvis SE: Effect of exorphins on gatrointestinal function, hormonal release, and appetite. Gastroenterology 84:1517–1523, 1983

    PubMed  Google Scholar 

  26. Schang JC, Devroede G: Beneficial effects of naloxone in a patient with intestinal pseudoobstruction. Am J Gastroenterol 80:407–411, 1985

    PubMed  Google Scholar 

  27. Sharpe GR, Rees WDW, Adrian TE, Christofides ND, Bloom SR: Effect of naloxone on the antral motor response to solid food in man. Eur J Clin Invest 17:95–99, 1987

    PubMed  Google Scholar 

  28. Champion MCC, Sullivan SN, Chamberlain M, Vezina W: Naloxone and morphine inhibit gastric emptying of solids. Can J Physiol Pharmacol 60:732–734, 1982

    PubMed  Google Scholar 

  29. Sawynok J, Pinsky C, LaBella FS: Minireview on the specificity of naloxone as an opiate antagonist. Life Sci 25:1621–1632, 1979

    PubMed  Google Scholar 

  30. Chapman RW, Sillery JK, Graham MM, Saunders DR: Absorption of starch by healthy ileostomates: Effect of transit time and of carbohydrate load. Am J Clin Nutr 41:1244–1248, 1985

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cattedra di Patologia Medica III, Istituto di Scienze Mediche, and Istituto di Clinica Chirurgica III, Università degli Studi di Milano, via F. Sforza 35, 20122, Milano, Italy

    G. Basilisco MD, G. Camboni MD, A. Bozzani MD, P. Vita MD, S. Doldi MD &  P. A. Bianchi MD

Authors
  1. G. Basilisco MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Camboni MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Bozzani MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Vita MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Doldi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. A. Bianchi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Basilisco, G., Camboni, G., Bozzani, A. et al. Orocecal transit delay in obese patients. Digest Dis Sci 34, 509–512 (1989). https://doi.org/10.1007/BF01536325

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01536325

Key words

Search

Navigation