Summary
Solid-cystic (papillary-cystic) tumours (SCT) of the pancreas are distinctive neoplasms with a predilection for young female patients. This is the first detailed report describing the occurrence of SCT in two young male patients. Except for the extrapancreatic occurrence of one of the tumours (in the retroperitoneal region behind the head of the pancreas), all other clinicopathological features were identical to those characterizing the SCT in women. Immunostaining was (at least focally) positive for Lu 5 (broad spectrum keratin marker), vimentin and alpha-1-antitrypsin. The tumours were negative for neuroendocrine markers (except for neuron-specific enolase), pancreatic hormones and enzymes, pancreatic stone protein, carcinoembryonic antigen, CA 19-9 and nuclear oestrogen and progesterone receptors. This report does not support the suggested female sex hormone dependence of SCT.
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Bombi JA, Milla A, Badal JM, Piulachs J, Estape J, Cardesa A (1984) Papillary-cystic neoplasm of the pancreas: report of two cases and review of the literature. Cancer 54:780–784
Cappellari JO, Geisinger KR, Albertson DA, Wolfman NT, Kute TE (1990) Malignant papillary cystic tumor of the pancreas. Cancer 66:193–198
Carbone A, Ranelletti FO, Rinell A, Vecchio FM, Lauriola L, Piantelli M, Capelli A (1989) Papillary cystic tumor of pancreas: a sex hormone-dependent tumor? (abstract) Pathol Res Pract 185:29
Choi BI, Kim KW, Han MC, Kim YI, Kim C-W (1988) Solid and papillary epithelial neoplasms of the pancreas: CT findings. Radiology 166:413–416
Chott A, Klöppel G, Buxbaum P, Heitz PU (1987) Neuron specific enolase demonstration in the diagnosis of a solid-cystic (papillary cystic) tumour of the pancreas. Virchows Arch [A] 410:397–402
Cubilla AL, Fitzgerald PJ (1984) Tumors of the exocrine pancreas. In: Hartmann WH (ed) Atlas of tumor pathology, 2nd series, fascicle 19. Armed Forces Institute of Pathology, Washington, D.C., pp 201–207
De Lagausie P, Maillet B, Viala T, Sudan N, Monges G (1988) Un cas de tumeur papillaire du pancréas. Gastroenterol Clin Biol 12:965–967
Duff P, Greene VP (1985) Pregnancy complicated by solid-papillary epithelial tumor of the pancreas, pulmonary embolism, and pulmonary embolectomy. Am J Obstet Gynecol 152:80–81
Frantz VK (1959) Tumors of the pancreas. Atlas of tumor pathology, section 7, fascicles 27 and 28. Armed Forces Institute of Pathology, Washington, D.C. pp 32–33
Friedman AC, Lichtenstein JE, Fishman EK, Oertel JE, Dachman AH, Siegelman SS (1985) Solid and papillary epithelial neoplasm of the pancreas. Radiology 154:333–337
Heitz PU, Stolte M, Klöppel G (1989) Large pancreatic tumor in a young woman. Ultrastruct Pathol 13:589–592
Kamisawa T, Fukayama M, Koike M, Tabata I and Okamoto A (1987) So-called “papillary and cystic neoplasm of the pancreas”. Acta Pathol Jpn 37:785–794
Kim YI, Kim ST, Lee GK, Choi BI (1990) Papillary cystic tumor of the liver: a case report with ultrastructural observation. Cancer 65:2740–2746
Klöppel G, Morohoshi T, John HD, Oehmichen W, Opitz K, Angelkort A, Lietz H, Rückert K (1981) Solid and cystic acinar cell tumour of the pancreas. A tumour in young women with favourable prognosis. Virchows Arch [A] 392:171–183
Ladanyi M, Mulay S, Arseneau J, Bettez P (1987) Estrogen and progesterone receptor determination in the papillary cystic neoplasm of the pancreas. With immunohistochemical and ultrastructural observations. Cancer 60:1604–1611
Lieber MR, Lack EE, Roberts JR, Merino MJ, Patterson K, Restrepo C, Solomon D, Chandra R, Triche TJ (1987) Solid and papillary epithelial neoplasm of the pancreas. An ultrastructural and immunocytochemical study of six cases. Am J Surg Pathol 11:85–93
Matsunou H, Konishi F (1990) Papillary-cystic neoplasm of the pancreas: a clinicopathologic study concerning the tumor aging and malignancy of nine cases. Cancer 65:283–291
Miettinen M, Partanen S, Fräki O, Kivilaakso E (1987) Papillary cystic tumor of the pancreas. An analysis of cellular differentiation by electron microscopy and immunohistochemistry. Am J Surg Pathol 11:855–865
Morohoshi T, Kanda M, Horie A, Chott A, Dreyer T, Klöppel G, Heitz PU (1987) Immunocytochemical markers of uncommon pancreatic tumors. Cancer 59:739–747
Oertel JE, Mendelsohn G, Compagno J (1982) Solid and papillary epithelial neoplasms of the pancreas. In: Humphrey GB, Grindey GB, Dehner LP, Acton RT, Pysher TJ (eds) Pancreatic tumors in children. Martinus Nijhoff, Den Haag, pp 167–171
Sanfey H, Mendelsohn G, Cameron JL (1983) Solid and papillary neoplasm of the pancreas: a potentially curable surgical lesion. Ann Surg 197:272–275
Schlosnagle DC, Campbell WG (1981) The papillary and solid neoplasm of the pancreas: a report of two cases with electron microscopy, one containing neurosecretory granules. Cancer 47:2603–2610
Wrba F, Chott A, Ludvik B, Schratter M, Spona J, Reiner A, Schernthaner G, Krisch K (1988) Solid and cystic tumour of the pancreas: a hormonal-dependent neoplasm? Histopathology 12:338–340
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Klöppel, G., Maurer, R., Hofmann, E. et al. Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: Report of two patients. Vichows Archiv A Pathol Anat 418, 179–183 (1991). https://doi.org/10.1007/BF01600295
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DOI: https://doi.org/10.1007/BF01600295