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Expression ofHer2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma

  • Original Papers
  • Clinical Oncology
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Summary

The expression of theHer2/neu gene product p 185 was retrospectively analyzed in 58 patients with gastric carcinoma. The results were correlated to various clinicopathological and prognostic factors. Positive membrane staining for p185 could be detected in 38% of the patients (22/58). Membrane staining was significantly greater in well and moderately differentiated tumors of the intestinal type when compared with poorly differentiated lesions and carcinomas of the diffuse type (P<0.01). Positive membrane staining did not correlate with site and tumor stage, but T1 lesions had less membrane staining than more advanced primary tumors. Overall survival showed no difference between p185-positive and negative cases. Multivariate analysis defined a subgroup of curatively resected patients with stage III and IV disease that had a statistically significant poorer survival when p185 was overexpressed (P=0.005). Overexpression of theHer2/neu product p185 appears to be associated with intestinal-type gastric carcinoma and may sociated with intestinal-type gastric carcinoma and may help in identifying a subset of patients at increased risk for shorter survival.

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Abbreviations

PBS:

phosphate-buffered saline

BSA:

bovine serum albumin

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Authors and Affiliations

  1. Clinic for Abdominal and Transplantation Surgery, Medical School Hannover, Konstanty-Gutschow-Str. 8, W-3000, Hannover 61, Germany

    J. Jaehne & H. J. Meyer

  2. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA

    C. Urmacher & C. Cordon-Cardo

  3. Department of Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA

    H. T. Thaler & H. Friedlander-Klar

Authors
  1. J. Jaehne
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  2. C. Urmacher
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  3. H. T. Thaler
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  4. H. Friedlander-Klar
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  5. C. Cordon-Cardo
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  6. H. J. Meyer
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Dedicated to Professor Dr. R. Pichlmayr on the occasion of his 60th birthday

This work was supported by a research fellowship from the Deutsche Forschungsgemeinschaft (Ja 509/2-1) and by a grant from the Wells foundation

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Jaehne, J., Urmacher, C., Thaler, H.T. et al. Expression ofHer2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma. J Cancer Res Clin Oncol 118, 474–479 (1992). https://doi.org/10.1007/BF01629433

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  • DOI: https://doi.org/10.1007/BF01629433

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