Summary
Strain SLCC 4013 ofListeria monocytogenes is susceptiblein vitro to ampicillin (MIC 0.5 mg/l) as well as to gentamicin (MIC 0.5 mg/l). Whereas treatment of mice infected with this virulent strain with 0.5 mg ampicillin twice a day resulted in a marked decrease in bacterial counts per spleen, the administration of 2 mg gentamicin twice a day hardly reduced bacterial multiplication. The combination of both drugs was not much more effective than ampicillin alone. Thus, a synergistic effect of both these antibiotics on intracellularly growing bacteria could not be demonstrated.
Zusammenfassung
Der Stamm SLCC 4013 vonListeria monocytogenes warin vitro empfindlich gegenüber Ampicillin (MHK 0,5 mg/l) und Gentamicin (MHK 0,5 mg/l). Mäuse wurden zweimal pro Tag mit je 2 mg Ampicillin oder mit 2 mg Gentamicin behandelt, nachdem sie mit diesem virulenten Listerien-Stamm infiziert worden waren. Während die Behandlung mit Ampicillin die Keimzahlen pro Milz deutlich senkte, war Gentamicin nur wenig wirksam. Die Kombination der beiden Antibiotika hatte keinen synergistischen Effekt auf diese intrazellulär vermehrungsfähigen Bakterien.
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Hof, H., Gückel, H. Lack of synergism of ampicillin and gentamicin in experimental listeriosis. Infection 15, 40–41 (1987). https://doi.org/10.1007/BF01646117
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DOI: https://doi.org/10.1007/BF01646117