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Activity of trimethoprim/ sulfamethoxazole plus polymyxin B against multiresistantStenotrophomonas maltophilia

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Abstract

The inhibitory activity of eight antibiotics and the inhibitory and bactericidal activities of combinations of trimethoprim/sulfamethoxazole (TMP/SMX) plus three fixed concentrations of polymyxin B (0.01 μg/ml, 0.1 μg/ml and 0.5 μg/ml) against 30 multiresistant strains ofStenotrophomonas maltophilia were tested. Polymyxin B at 0.01 μg/ml modified the inhibitory activity of TMP/SMX against only 40% of strains. At 0.1 μg/ml and 0.5 μg/ml, polymyxin B enhanced the inhibitory activity of TMP/SMX activity against all strains. Polymyxin B enhanced the bactericidal activity of TMP/SMX only at concentrations near the minimum inhibitory concentration of polymyxin B alone.

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Muñoz, J.L., García, M.I., Muñoz, S. et al. Activity of trimethoprim/ sulfamethoxazole plus polymyxin B against multiresistantStenotrophomonas maltophilia . Eur. J. Clin. Microbiol. Infect. Dis. 15, 879–882 (1996). https://doi.org/10.1007/BF01691222

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