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Twenty-three cases of acute lymphoblastic leukemia with translocation t(4;11)(q21;q23): the implication of additional chromosomal aberrations

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Abstract

The translocation t(4;11)(q21;q23) is one of the most common specific chromosomal aberrations in acute lymphoblastic leukemia (ALL), occurring in 2% of childhood and in 5–6% of adult cases. Especially in adults, the t(4;11) is associated with a poor prognosis. In order to determine the significance of clonal chromosome aberrations that occur in addition to t(4;11), we studied the karyotypes and clinical courses of 23 patients with acute lymphoblastic leukemia and a translocation t(4;11)(q21;q23). Additional clonal chromosome aberrations were found in ten patients. An isochromosome i(7)(q10) and a trisomy 6 were observed most frequently as secondary anomalies. Clonal evolution was detected in four of six patients analyzed at diagnosis as well as at relapse. With treatment carried out according to modern risk-adapted therapy protocols, no difference in outcome was observed between patients with clonal chromosome aberrations in addition to t(4;11) at diagnosis and those without.

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Authors and Affiliations

  1. Arbeitsgruppe Tumorcytogenetik, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany

    C. Schoch, H. Rieder & C. Fonatsch

  2. Department of Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany

    M. Freund

  3. Department of Hematology and Oncology, University of Frankfurt, Frankfurt/Main, Germany

    D. Hoelzer

  4. Department of Pediatrics IV, Medizinische Hochschule Hannover, Hannover, Germany

    H. Riehm

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  1. C. Schoch
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  2. H. Rieder
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  3. M. Freund
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  4. D. Hoelzer
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  5. H. Riehm
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  6. C. Fonatsch
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Schoch, C., Rieder, H., Freund, M. et al. Twenty-three cases of acute lymphoblastic leukemia with translocation t(4;11)(q21;q23): the implication of additional chromosomal aberrations. Ann Hematol 70, 195–201 (1995). https://doi.org/10.1007/BF01700375

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  • DOI: https://doi.org/10.1007/BF01700375

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