Abstract
A report is presented about studies on poliovirus type 3 isolates from vaccine-associated cases or contacts of cases of paralytic poliomyelitis, observed over a period of 30 years in East Germany (former GDR). In the viral isolates, some mutations were found in comparison to the Sabin vaccine type 3 strain, distributed over the whole genome. The significance of these mutations has been discussed, especially the mutation at position 472 in the 5′ non-coding region found in all the isolates investigated. In five isolates, intertypic recombination between Sabin type 3 and Sabin type 1 vaccine strain occurred. Primary and secondary structures were analysed for the recombination sites.
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Driesel, G., Diedrich, S., Künkel, U. et al. Vaccine-associated cases of poliomyelitis over a 30 year period in East Germany. Eur J Epidemiol 11, 647–654 (1995). https://doi.org/10.1007/BF01720298
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DOI: https://doi.org/10.1007/BF01720298