Abstract
The associations between exogenous hormones, reproductive history, and colon cancer were investigated in a case-control study among women aged 30–62 years. The study was conducted in the Seattle, Washington (USA) metropolitan area between 1985 and 1989 and included 193 incident cases of colon cancer and 194 controls. There was little overall association between colon cancer and oral contraceptive use, parity, age at first birth, hysterectomy or oophorectomy status, or age at menopause. Use of noncontraceptive hormones at or after age 40, most likely hormone replacement therapy (HRT), was associated with decreased risk of colon cancer (adjusted odds ratio [OR]=0.60, 95 percent confidence interval [CI]=0.35–1.01), particularly among women with more than five years of use (OR=0.47, 95 percent CI=0.24–0.91). While results from previous studies have not been consistent, any protective effect of HRT against colon cancer would be important given the continuing debate over its potential risks and benefits.
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Fraumeni JF Jr., Lloyd JW, Smith EM, Wagoner JK. Cancer mortality among nuns: Role of marital status in etiology of neoplastic disease in women.JNCI 1969;42: 455–68.
McMichael AJ, Potter JD. Reproduction, endogenous and exogenous sex hormones, and colon cancer: A review and hypothesis.JNCI 1980;65: 1201–7.
Reddy BS, Watanabe K, Weisburger JH, Wynder EL. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.Cancer Res 1977;37: 2533–9.
Narisawa T, Magadia NE, Weisburger JH, Wynder EL. Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N′ nitrosoguanidine in rats.JNCI 1974;53: 1093–7.
Peters RK, Pike MC, Chang WW, Mack TM. Reproductive factors and colon cancers.Br J Cancer 1990;61: 741–8.
Gerhardsson de Verdier M, London S. Reproductive factors, exogenous female hormones, and colorectal cancer by subsite.Cancer Cances Control 1992;3: 355–60.
Meyer F, White E. Alcohol and nutrients in relation to colon cancer in middle-aged adults.Am J Epidemiol 1993;138: 225–6.
Harlow BL, Davis S. Two one-step methods for household screening and interviewing using random digit dialing.Am J Epidemiol 1988;127: 857–63.
Breslow NE, Day NE, eds.Statistical Methods in Cancer Research. Vol 1. The Analysis of Case-control Studies. Lyon, France: International Agency for Research on Cancer, 1980. IARC Sci. Pub. No. 32.
Mantel N. Chi-square tests with one degree of freedom: extensions of the Mantel-Haenszel procedure.J Am Stat Assoc 1963;58: 690–700.
Weiss NS, Daling JR, Chow WH. Incidence of cancer of the large bowel in women in relation to reproductive and hormonal factors.JNCI 1981;67: 57–60.
McMichael AJ, Potter JD. Parity and death from colon cancer in women.Community Health Stud 1984;8: 19–24.
Kune GA, Kune S, Watson LF. Children, age at first birth, and colorectal cancer risk. Data from the Melbourne Colorectal Cancer Study.Am J Epidemiol 1989;129: 533–42.
Kravdal O, Glattre E, Kvale G, Tretli S. A sub-site-specific analysis of the relationship between colorectal cancer and parity in complete male and female Norwegian birth cohorts.Int J Cancer 1993;53: 56–61.
Potter JD, McMichael AJ. Large bowel cancer in women in relation to reproductive and hormonal factors: A case-control study.JNCI 1983;71: 703–9.
Wu AH, Paganini-Hill RK, Ross RK, Henderson BE. Alcohol, physical activity and other risk factors for colorectal cancer: A prospective study.Br J Cancer 1987;55: 687–94.
Miller AB, Barclay THC, Choi NW, et al. A study of cancer, parity and age at first pregnancy.J Chronic Dis 1980;33: 595–605.
Byers T, Graham S, Swanson M. Parity and colorectal cancer risk in women.JNCI 1982;69: 1059–62.
Papadimitriou C, Day N, Tzonous A, Gerovassilis F, Manousos O, Trichopoulos D. Biosocial correlates of colorectal cancer in Greece.Int J Epidemiol 1984;13: 155–9.
Howe GR, Craib KJP, Miller AB. Age at first pregnancy and risk of colorectal cancer: A case-control study.JNCI 1985;74: 1155–9.
Plesko I, Preston-Martin S, Day NE, Tzonou A, Dimitrova E, Somogyi J. Parity and cancer risk in Slovakia.Int J Cancer 1985;36: 529–33.
Furner SE, Davis FG, Nelson RL, Haenszel W. A case-control study of large bowel cancer and hormone exposure in women.Cancer Res 1989;49: 4936–40.
Negri E, La Vecchia C, Parazzini F, et al. Reproductive and menstrual factors and risk of colorectal cancer.Cancer Res 1989;49: 7158–61.
Chute CG, Willett WC, Colditz GA, Stampfer MJ, Rosner B, Speizer FE. A prospective study of reproductive history and exogenous estrogens on the risk of colorectal cancer in women.Epidemiology 1991;2: 201–7.
Kvale G, Heuch I. Is the incidence of colorectal cancer related to reproduction? A prospective study of 63,000 women.Int J Cancer 1991;47: 390–5.
Dales LG, Friedman GD, Ury HK, Grossman S, Williams SR. A case-control study of the relationships of diet and other traits to colorectal cancer in American blacks.Am J Epidemiol 1978;109: 132–44.
Franceschi S, Bidoli E, Talamini R, Barra S, La Vecchia C. Colorectal cancer in northeast Italy: Reproductive, menstrual and female hormone related factors.Eur J Cancer 1991;27: 604–8.
Davis FG, Furner SE, Persky V, Koch M. The influence of parity and exogenous female hormones on the risk of colorectal cancer.Int J Cancer 1989;43: 587–90.
Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations and medications: case-control results from the Melbourne colorectal cancer study.Cancer Res 1988;48: 4399–404.
Derby CA, Hume AL, McFarland Barbour M, McPhillips JB, Lasater TM, Carleton RA. Correlates of postmenopausal estrogen use and trends through the 1980s in two southeastern New England communities.Am J Epidemiol 1993;137: 1125–35.
Ross RK, Paganini-Hill A, Roy S, Chao A, Henderson BE. Past and present preferred prescribing practices of hormone replacement therapy among Los Angeles gynecologists: Possible implications for public health.Am J Public Health 1988;78: 516–9.
McMichael AJ, Potter JD. Host factors in carcinogenesis: Certain bile-acid metabolic profiles that selectively increase the risk of proximinal colon cancer.JNCI 1985;75: 185–91.
Musey VC, Collins DC, Musey PI, Martino-Saltzman D, Preedy JRK. Long-term effect of a first pregnancy on the secretion of prolactin.N Engl J Med 1987;316: 229–34.
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Support for this study was provided by grant CA44790. Mr Jacobs was supported by the Cancer Prevention Training Grant T32 CA09661. This study was performed at the Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA.
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Jacobs, E.J., White, E. & Weiss, N.S. Exogenous hormones, reproductive history, and colon cancer (Seattle, Washington, USA). Cancer Causes Control 5, 359–366 (1994). https://doi.org/10.1007/BF01804987
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DOI: https://doi.org/10.1007/BF01804987