Summary
Four hundred and sixty patients with stage II or III breast cancer following regional therapy were treated with an adjuvant combination chemotherapy consisting of fluorouracil, doxorubicin, and cyclophosphamide (FAC). The relationship between the length of disease-free survival and length of delays in initiation of chemotherapy after surgery was evaluated. Patients were divided into four subgroups according to the length of delay in initiation of chemotherapy (< 10 weeks, 10–13, 14–17, and ≥ 18 weeks). Overall four year diseasefree survival was 64%, 68%, 60%, and 63% for patient groups with delays of < 10 weeks, 10–13, 14–17, or ≥ 18 weeks respectively (p = 0.39). There was no trend for longer delay in treatment to be associated with shorter disease-free survival, except in poor prognosis patients.
References
Schabel FM: Experimental basis of adjuvant chemotherapy.In SE Salmon and SE Jones (eds): Adjuvant Therapy of Cancer. Elsevier/North-Holland Biomedical Press, Amsterdam, 1977, p 3–14
Goldie JH, Coldman AJ: A mathematical model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 63: 1727–1733, 1979
Blumenschein G, Buzdar A, Hortobagyi G, Yap H: Adjuvant chemo-immunotherapy of regionally treated stage IV breast cancer patients: A five year follow-up.In SE Salmon and SE Jones (eds): Adjuvant Therapy of Cancer III. Grune and Stratton, New York, 1981, pp 427–434
Bonadonna G, Valagussa P: Dose response effect of adjuvant chemotherapy in breast cancer. New Engl J Med 304: 10–15, 1981
Buzdar AU, Gutterman JU, Blumenschein GR, Hortobagyi GN, Tashima CK, Montague E, Hersch EM, Freireich EJ, Gehan E: Intensive post-operative chemotherapy in patients with stage II and III breast cancer. Cancer 41: 1064–1076, 1978
Buzdar A, Smith T, Blumenschein G, Hortobagyi G, Hersh E, Gehan E: Adjuvant chemotherapy with fluorouracil, doxorubicin and cyclophosphamide (FAC) for stage II or III breast cancer: 5-year results.In SE Salmon and SE Jones (eds): Adjuvant Therapy of Cancer III. Grune & Stratton, New York, 1981, pp 419–426
Gehan EA: A generalized Wilcoxon test for comparing arbitrarily single censored samples. Biometrika 52: 203–223, 1965
Breslow N: A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship. Biometrika 57: 579–594, 1970
Nissen-Meyer R, Kjellgren K, Malmio K, Mansson B, Norin T: Surgical adjuvant chemotherapy results with one short course with cyclophosphamide after mastectomy for breast cancer. Cancer 41: 2088–2098, 1978
Cooper RG, Holland JF, Glidewell O: Adjuvant chemotherapy of breast cancer. Cancer 44: 793–798, 1979
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Buzdar, A.U., Smith, T.L., Powell, K.C. et al. Effect of timing of initiation of adjuvant chemotherapy on disease-free survival in breast cancer. Breast Cancer Res Tr 2, 163–169 (1982). https://doi.org/10.1007/BF01806452
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DOI: https://doi.org/10.1007/BF01806452