Skip to main content
SpringerLink
Log in

Heat shock proteins: the hsp70 family

  • Multi-Author Reviews
  • Published:
Experientia Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Abravaya, K., Myers, M. P., Murphy, S. P., and Morimoto, R. I., The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev.6 (1992) 1153–1164.

    Article  CAS  PubMed  Google Scholar 

  2. Agard, D. A., To fold or not to fold ... Science260 (1993) 1903–1904.

    Article  CAS  PubMed  Google Scholar 

  3. Arnold, B., Schönrich, G., and Hämmerling, G. J., Multiple levels of peripheral tolerance. Immun. Today14 (1993) 12–14.

    Article  CAS  PubMed  Google Scholar 

  4. Barrios, C., Lussow, A. R., Van Embden, J., Van der Zee, R., Rappuoli, R., Costantino, P., Louis, J. A., Lambert, P.-H., and Del Giudice, G., Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-KDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin priming. Eur. J. Immun.22 (1992) 1365–1372.

    Article  CAS  Google Scholar 

  5. Becker, J., and Craig, E. A., Heat-shock proteins as molecular chaperones. Eur. J. Biochem.219 (1994) 11–23.

    Article  CAS  PubMed  Google Scholar 

  6. Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennet, W. S., Strominger, J. L., and Wiley, D. C., Structure of the human class I histocompatibility antigen, HLA-A2. Nature329 (1987) 506–512.

    Article  CAS  PubMed  Google Scholar 

  7. Blond-Elguindi, S., Cwirla, S. E., Dower, W. J., Lipshutz, R. J., Sprang, S. R., Sambrook, J. R., and Gething, M.-J., Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell75 (1993) 717–728.

    Article  CAS  PubMed  Google Scholar 

  8. Brown, C. R., Martin, R. L., Hansen, W. J., Beckmann, R. P., and Welch, W. J., The constitutive and stress inducible forms of hsp70 exhibit functional similarities and interact with one another in an ATP-dependent fashion. J. Cell Biol.120 (1993) 1101–1112.

    Article  CAS  PubMed  Google Scholar 

  9. Buus, S., Sette, A., Colon, S. M., Janis, D. M., and Grey, H. M., Isolation and characterization of antigen-Ia complexes involved in T cell recognition. Cell47 (1986) 1071–1077.

    Article  CAS  PubMed  Google Scholar 

  10. Cascino, I., Sorrentino, R., and Tosi, R., Strong genetic association between HLA-DR3 and a polymorphic variation in the regulatory region of the HSP70-1 gene. Immunogenetics37 (1993) 177–188.

    Article  CAS  PubMed  Google Scholar 

  11. Cohen, I. R., Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes. A. Rev. Immun.9 (1991) 567–589.

    Article  CAS  Google Scholar 

  12. Craig, E. A., Chaperones: Helpers along pathways to protein folding. Science260 (1993) 1902–1903.

    Article  CAS  PubMed  Google Scholar 

  13. Cristau, B., Schafer, P. H., and Pierce, S. K., Heat shock enhances antigen processing and accelerates the formation of compact class II αβ dimers. J. Immun.152 (1994) 1546–1556.

    Article  CAS  PubMed  Google Scholar 

  14. Daibata, M., Xu, M., Humphreys, R. E., and Reyes, V. E., More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release. Molec. Immun.31 (1994) 255–260.

    Article  CAS  PubMed  Google Scholar 

  15. Del Giudice, G., Hsp70: A carrier molecule with built-in adjuvanticity. Experientia50 (1994) 1061–1066.

    Article  PubMed  Google Scholar 

  16. DeNagel, D. C., and Pierce, S. K., A case for chaperones in antigen processing. Immun. Today13 (1992) 86–89.

    Article  CAS  PubMed  Google Scholar 

  17. Domanico, S. Z., DeNagel, D. C., Dahlseid, J. N., Green, J. F., and Pierce, S. K., Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. Molec. cell. Biol.13 (1993) 3598–3610.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Elias, D., and Cohen, I. R., Peptide therapy for diabetes in NOD mice. Lancet343 (1994) 704–706.

    Article  CAS  PubMed  Google Scholar 

  19. Feige, U., and Cohen, I. R., The 65 kDa heat shock protein (hsp65) in the pathogenesis, prevention and therapy of autoimmune arthritis and diabetes mellitus in rats and mice. Springer Semin. Immunopath.13 (1991) 99–113.

    Article  CAS  Google Scholar 

  20. Feige, U., and Gasser, J., Therapeutic intervention with mycobacterial heat shock protein peptide 180–188 in adjuvant arthritis in Lewis rats. Mediat. Inflammat.3 (1994) 304.

    Google Scholar 

  21. Flaherty, K. M., DeLuca-Flaherty, C., and McKay, D. B., Three-dimensioinal structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature346 (1990) 623–628.

    Article  CAS  PubMed  Google Scholar 

  22. Flaherty, K. M., McKay, D. B., Kabsch, W., and Holmes, K. C., Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein. Proc. natl. Acad. Sci. USA88 (1991) 5041–5045.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Flajnik, M. F., Canel, C., Kramer, J., and Kasahara, M., Which came first, MHC class I or class II? Immunogenetics33 (1991) 295–300.

    Article  CAS  PubMed  Google Scholar 

  24. Flynn, G. C., Pohl, J., Flocco, M. T., and Rothman, J. E., Peptide-binding specificity of the molecular chaperone BiP. Nature353 (1991) 726–730.

    Article  CAS  PubMed  Google Scholar 

  25. Fruman, D. A., Burakoff, S. J., and Bierer, B. E., Immunophilins in protein folding and immunosuppression. FASEB J.8 (1994) 391–400.

    Article  CAS  PubMed  Google Scholar 

  26. Frydman, J., Nimmesgern, E., Ohtsuka, K., and Hartl, U., Folding of nascent polypeptide chains in high molecular mass assembly with molecular chaperones. Nature370 (1994) 111–117.

    Article  CAS  PubMed  Google Scholar 

  27. Galat, A., Peptidylprolinecis-trans-isomerases: immunophilins. Eur. J. Biochem.216 (1993) 689–707.

    Article  CAS  PubMed  Google Scholar 

  28. Gaston, J. S. H., Are heat shock proteins involved in autommunity? Int. J. clin. lab. Res.22 (1992) 90–94.

    Article  CAS  PubMed  Google Scholar 

  29. Gething, M.-J., and Sambrook, J., Protein folding in the cell. Nature355 (1992) 33–45.

    Article  CAS  PubMed  Google Scholar 

  30. Günther, E. and Walter, L., Genetic aspects of the hsp70 multigene family in vertebrates. Experientia50 (1994) 987–1001.

    Article  PubMed  Google Scholar 

  31. Haas, I. G., BiP (GRP78), an essential hsp70 resident protein in the endoplasmatic reticulum. Experientia50 (1994) 1012–1020.

    Article  CAS  PubMed  Google Scholar 

  32. Hall, T. J., Role of hsp70 in cytokine secretion. Experientia50 (1994) 1048–1053.

    Article  CAS  PubMed  Google Scholar 

  33. Hannavy, K., Rospert, S., and Schatz, G., Protein import into mitochondria: a paradigm for the translocation of polypeptides across membranes. Curr. Opinion Cell Biol.5 (1993) 694–700.

    Article  CAS  PubMed  Google Scholar 

  34. Heydari, A. R., Takahashi, R., Gutsmann, A., You, S., and Richardson, A., Hsp70 and aging Experientia50 (1994) 1092–1098.

    Article  CAS  PubMed  Google Scholar 

  35. Jäättelä, M., Saskela, K. and Saskela, K., Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factor α and β. Eur. J. Immun.19 (1989) 1413–1417.

    Article  Google Scholar 

  36. Jacquier-Sarlin, M. R., Fuller, K., Dinh-Xuan, A. T., Richard, M.-J., and Polla, B. S., Protective effects of hsp70 in inflammation. Experientia50 (1994) 1031–1038.

    Article  CAS  PubMed  Google Scholar 

  37. Jones, D. B., Coulson, A. F. W., and Duff, G. W., Sequence homologies between hsp60 and autoantigens. Immun. Today14 (1993) 115–118.

    Article  CAS  PubMed  Google Scholar 

  38. Kantengwa, S., and Polla, B. S., Phagocytosis ofStaphylococcus aureus induces a selective stress response in human monocytes-macrophages (Mϕ): Modulation by Mϕ differentiation and by iron. Infect. Immun.61 (1993) 1281–1287.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Kaufmann, S. H. E., (Ed), Heat shock proteins and immune response. Curr. Topics Microbiol. Immun.167 (1991).

  40. Koroshetz, W. J., and Bonventre, J. V., Heat shock response in the central nervous system. Experientia50 (1994) 1085–1091.

    Article  CAS  PubMed  Google Scholar 

  41. Lesk, A. M., and Hardman, K. D., Computer-generated pictures of proteins. Meth. Enzym.115 (1985) 381–390.

    Article  CAS  PubMed  Google Scholar 

  42. Maresca, B., and Kobayashi, G. S., Hsp70 in parasites: as an inducible protective protein and as an antigen. Experientia50 (1994) 1067–1074.

    Article  CAS  PubMed  Google Scholar 

  43. Mariéthoz, E., Tacchini-Cottier, F., Jacquier-Sarlin, M., Sinclair, F., and Polla, B. S., Exposure of monocytes to heat shock does not increase class II expression but modulates antigen-dependent T cell responses. Int. Immun.6 (1994) 925–930.

    Article  PubMed  Google Scholar 

  44. McKay, D. B., Wilbanks, S. M., Flaherty, K. M., Ha, J.-H., O'Brien, M. C., and Shirvanee, L. L., Stress-70 proteins and their interaction with nucleotides. see ref. 46 , pp. 153–177.

    Google Scholar 

  45. Morimoto, R. I., Tissieres, A., and Georgopoulos, C, (Eds), Stress Proteins in Biology and Medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1990.

    Google Scholar 

  46. Morimoto, R. I., Tissieres, A., and Georgopoulos, C., (Eds), The Biology of Heat Shock Proteins and Molecular Chaperones, Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1994.

    Google Scholar 

  47. Morimoto, R. I., Jurivich, D. A., Kroeger, P. E., Mathur, S. K., Murphy, S. P., Nakai, A., Sarge, K., Abravaya, K., and Sistonen, L. T., Regulation of heat shock gene transcription by a family of heat shock factors. see ref. 46 pp. 417–455.

    Google Scholar 

  48. Moseley, P. L., Wallen, E. S., McCafferty, J. D., Flanagan, S., and Kern, J. A., Heat stress regulates the human 70-kDa heat-shock gene through the 3′-untranslated region. Am. J. Physiol.264 (1993) L533-L537.

    CAS  PubMed  Google Scholar 

  49. Nadeau, K., Nadler, S. G., Saulnier, M., Tepper, M. A., and Walsh, C. T., Quantitation of the interaction of the immuno-suppressant deoxyspergualin and analogs with hsc70 and hsp90. Biochemistry33 (1994) 2561–2567.

    Article  CAS  PubMed  Google Scholar 

  50. Neefjes, J. J., and Momburg, F., Cell biology of antigen presentation. Curr. Opinion Immun.5 (1993) 27–34.

    Article  CAS  Google Scholar 

  51. Otterson, G. A., Flynn, G. C., Kratzke, R. A., Coxon, A., Johnston, P. G., and Kaye, F. J.,Stch encodes the ‘ATPase core’ of a microsomal stress70 protein. EMBO J.13 (1994) 1216–1225.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Palleros, D. R., Reid, K. L., Shi, L., Welch, W. J., and Fink, A. L., ATP-induced protein-hsp70 complex dissociation requires K+ and does not involve ATP hydrolysis. Analogy to G proteins. Nature365 (1993) 664–666.

    Article  CAS  PubMed  Google Scholar 

  53. Partanen, J., Milner, C., Campbell, R. D., Mäki, M., Lipsanen, V., and Koskimies, S., HLA-linked heat-shock protein 70 (HSP 70-2) gene polymorphism and celiac disease. Tissue Antigens41 (1993) 15–19.

    Article  CAS  PubMed  Google Scholar 

  54. Perdrizet, G. A., Kaneko, H., Buckley, T. M., Fishman, M. S., Pleau, M., Bow, L., and Schweizer, R. T., Heat shock and recovery protects renal allografts from warm ischemia injury and enhances HSP72 production. Transplantn Proc.25 (1993) 1670–1673.

    CAS  Google Scholar 

  55. Pierce, S. K., Molecular chaperones in the processing and presentation of antigen to helper T cells Experientia50 (1994) 1026–1030.

    Article  CAS  PubMed  Google Scholar 

  56. Polla, B. S., Perin, M., and Pizurki, L. Regulation and functions of stress proteins in allergy and inflammation. Clin. expl Allergy23 (1993) 548–556.

    Article  CAS  Google Scholar 

  57. Pratt, W. B., Scherrer, L. C., Hutchison, K. A., and Dalman, F. C., A model of glucocorticoid receptor unfolding and stabilization by a heat shock protein complex. J. Steroid Biochem. molec. Biol.41 (1992) 223–229.

    Article  CAS  PubMed  Google Scholar 

  58. Pratt, W. B., Czar, M. J., Stancato, L. F., and Owens, J. K., The hsp56 immunophilin component of the steroid receptor heterocomplexes: could this be the elusive nuclear localization signal-binding protein. J. Steroid Biochem. molec. Biol.46 (1993) 269–279.

    Article  CAS  PubMed  Google Scholar 

  59. Ratanachaiyavong, S., Demaine, A. G., Campbell, R. D., and McGregor, A. M., Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease. Clin. expl Immun.84 (1991) 48–52.

    CAS  Google Scholar 

  60. Rippmann, F., Taylor, W. R., Rothbard, J. R., and Green, N. M., A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA. EMBO J.10 (1991) 1053–1059.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Ritossa, F., A new puffing pattern induced by temperature shock and DNP inDrosophila. Experientia18 (1962) 571–573.

    Article  CAS  Google Scholar 

  62. Román, E., Moreno, C., and Young, D., Mapping of hsp70-binding sites on protein antigens. Eur. J. Biochem.222 (1994) 65–73.

    Article  PubMed  Google Scholar 

  63. Rothman, J. E., Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells. Cell59 (1989) 591–601.

    Article  CAS  PubMed  Google Scholar 

  64. Santoro, M. G., Heat shock proteins and virus replication: Hsp70 as mediators of the antiviral effects of prostaglandins. Experientia50 (1994) 1039–1047.

    Article  CAS  PubMed  Google Scholar 

  65. Schirmbeck, R., and Reimann, J., Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation. Eur. J. Immun.24 (1994) 1478–1486.

    Article  CAS  Google Scholar 

  66. Schmidt, J. A., and Abdulla, E., Down-regulation of IL-1β biosynthesis by inducers of the heat-shock response. J. Immun.141 (1988) 2027–2034.

    Article  CAS  PubMed  Google Scholar 

  67. Srivastava, P., and Maki, R. G., Stress-induced proteins in immune response to cancer. Curr. Topics Microbiol. Immun.167 (1991) 109–123.

    CAS  Google Scholar 

  68. Srivastava, P. K., Heat shock proteins in immune response to cancer: The fourth paradigm. Experientia50 (1994) 1054–1060.

    Article  CAS  PubMed  Google Scholar 

  69. Stover, C. K., Cruz, V. F. de la., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H., Hatfull, G. F., Snapper, S. B., Barletta, R. G., Jacobs, W. R. Jr., and Bloom, B. R., New use of BCG for recombinant vaccines. Nature351 (1991) 456–460.

    Article  CAS  PubMed  Google Scholar 

  70. Stuart, R. A., Cyr, D. M., and Neupert, W., Hsp70 in mitochondrial biogenesis: From chaperoning nascent polypeptide chains to facilitation of protein degradation. Experientia50 (1994) 1002–1011.

    Article  CAS  PubMed  Google Scholar 

  71. Terlecky, S. R., Chiang, H. L., Olson, T. S., and Dice, J. F., Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein. J. biol. Chem.267 (1992) 9202–9209.

    Article  CAS  PubMed  Google Scholar 

  72. Terlecky, S. R., Hsp70 and lysosomal proteolysis. Experientia50 (1994) 1021–1025.

    Article  CAS  PubMed  Google Scholar 

  73. Todd, M. J., Viitanen, P. V., and Lorimer, G. H., Dynamics of the chaperonin ATPase cycle: implications for facilitated protein folding. Science265 (1994) 659–666.

    Article  CAS  PubMed  Google Scholar 

  74. Van Eden, W., Heat shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis. Immun. Rev.121 (1991) 1–27.

    Article  Google Scholar 

  75. Villar, J., Edelson, J. D., Post, M., Mullen, B. M., and Slutzky, A. S., Induction of heat stress proteins is associated with decreased mortality in animal models of acute lung injury. Am. Rev. respir. Dis.147 (1993) 177–181.

    Article  CAS  PubMed  Google Scholar 

  76. Wadhwa, R., Kaul, S. C., and Mitsui, Y., Cellular mortality to immortalization: mortalin. Cell Struct. Funct.19 (1994) 1–10.

    Article  CAS  PubMed  Google Scholar 

  77. Winfield, J., and Jarjour, W., Do stress proteins play a role in arthritis and autoimmunity? Immun. Rev.121 (1991) 193–220.

    Article  CAS  PubMed  Google Scholar 

  78. Wynn, R. M., Davie, J. R., Cox, R. P., and Chuang, D. T., Molecular chaperones: heat shock proteins, foldases, and matchmakers. J. Lab. clin. Med.124 (1994) 31–36.

    CAS  PubMed  Google Scholar 

  79. Yang, X.-D., and Feige, U., Heat shock proteins in autoimmune disease. From cuasative antigen to specific therapy? Experientia48 (1992) 650–656.

    Article  CAS  PubMed  Google Scholar 

  80. Yellon, D. M., and Marber, M. S., Hsp70 in myocardial ischemia. Experientia50 (1994) 1075–1084.

    Article  CAS  PubMed  Google Scholar 

  81. Young, D. B., Mehlert, A., and Smith, D. F., Stress proteins in infectious diseases. see ref. 45, pp. 131–165.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Department, Pharmaceuticals Division, Ciba-Geigy, R-1056.184, CH-4002, Basel, Switzerland

    U. Feige

  2. Allergy Unit, University Hospital, CH-1211, Geneva 14, Switzerland

    B. S. Polla

  3. Laboratory for Respiratory Physiology, UFR Cochin Port-Royal, 27 rue du Faubourg St. Jacques, F-75014, Paris, France

    B. S. Polla

Authors
  1. U. Feige
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. S. Polla
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to our research laboratories, past, present and future, as the most wonderful place for thought and progress.

The editors wish to thank Dr. Ulrich Feige and Dr. Barbara Polla for having coordinated this review.Hsp70—a multi-gene, multi-structure, multi-function family with potential clinical applications

Rights and permissions

Reprints and permissions

About this article

Cite this article

Feige, U., Polla, B.S. Heat shock proteins: the hsp70 family. Experientia 50, 979–986 (1994). https://doi.org/10.1007/BF01923452

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01923452

Key words

Search

Navigation