Abstract
A differential amine release from mast cells induced by an inhibitory effect of the antidepressant drug amitriptyline on the release of histamine but not on that of serotonin has recently been reported. In view of the potential biological importance of a differential release of mast cell amines we have studied the effect of amitryptyline on the dynamics of the secretory process using a combination of vital berberine staining (demonstrating intracellular granules that have release amines) and measurement of histamine, serotonin (5-HT), and heparin release. The results show a non-differential inhibition of the release of histamine and 5-HT by amitriptyline. The basic pattern of the secretory process, studied in terms of granule extrusion and amine release from intracellular granules, was unaffected by the drug.
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Berlin, G., Enerbäck, L. Non-differential inhibition of histamine and serotonin release from mast cells by amitryiptyline. Agents and Actions 18, 89–91 (1986). https://doi.org/10.1007/BF01987991
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DOI: https://doi.org/10.1007/BF01987991