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Changes in the peripheral vasculature of various organs in patients with sarcoidosis—Possible role of microangiopathy

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Summary

Vascular involvement in sarcoidosis is briefly reviewed with emphasis on the outcome of a 10-year project-study by the Sarcoidosis Research Committee of the Japanese Ministry of Health and Welfare. Examples of vascular disorder associated with sarcoidosis are presented, including basal lamina layering of the capillaries in the skeletal muscle, cardiac muscle, and lung, glomerulopathy in the kidney, vascular changes in the ocular fundus and bronchi, and impaired peripheral circulation that could be detected by thermography. According to our tentative definition, all of these disorders should be collectively called microangiopathy. The possible role of microangiopathy in the pathogenetic mechanism of sarcoidosis is also discussed. Although microangiopathy in sarcoidosis is a comprehensive term, it should be included, in addition to systemic granulomatous disease, as part of the clinicopathological entity of sarcoidosis.

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References

  1. Kobayashi F (1981) On microangiopathy of sarcoid retinochoroidopathy. In: Japan Medical Research Foundation (eds) Sarcoidosis. University of Tokyo Press, Tokyo, pp 99–108

    Google Scholar 

  2. Mikami R, Shibata S, Shimada Y, Fuse Y, Kobayashi F, Ryujin Y (1981) Microangiopathy and nephropathy in sarcoidosis. In: Japan Medical Research Foundation (eds) Sarcoidosis. University of Tokyo Press, Tokyo, pp 109–128

    Google Scholar 

  3. Kobayashi T, Hiraga Y, Ogiwara M, Washizaki M, Okano H, Ryujin Y, Kosuda T, Mochizuki I, Ozawa K, Mikami R (1983) Vascular changes in bronchoscopy in patients with sarcoidosis. In: Chrétien J, Marsac J, Saltiel JC (eds) Sarcoidosis and other granulomatous disorders. Pergamon, Paris, pp 652–654

    Google Scholar 

  4. Hiraga Y, Kikuchi K, Nakahashi M, Kobayashi F, Mikami R, Ryujin Y, Hosoda Y (1983) Abnormalities in finger circulation in sarcoidosis. In: Chrétien J, Marsac J, Saltiel JC (eds) Sarcoidosis and other granulomatous disorders. Pergamon, Paris, pp 652–654

    Google Scholar 

  5. Bloodworth JMB Jr, Engerman RL, Daivs MD (1971) Pathology of diabetic microangiopathy. In: Rodriguez RR (ed) Diabetes. Excerpta Medica, Amsterdam, Excerpta Medica ICS, 231: 804–819

    Google Scholar 

  6. James DG (1959) Ocular sarcoidosis. Am J Med 26: 331–339

    Google Scholar 

  7. Gould H, Kaufman HE (1961) Sarcoid of the fundus. AMA Arch Ophthal 65: 453–456

    Google Scholar 

  8. Giovannini A, Colombati S (1983) Angiographic diagnosis in ocular sarcoidosis. In: Chrétien J, Marsac J, Saltiel JC (eds) Sarcoidosis and other granulomatous disorders. Pergamon, Paris, pp 614–615

    Google Scholar 

  9. James DG (1986) Ocular sarcoidosis. Ann Ny Acad Sci 465: 551–563

    Google Scholar 

  10. Wallace SL, Lattes R, Malia JP, Ragan C (1958) Muscle involvement in Boeck's sarcoid. Ann Int Med 48: 497–511

    Google Scholar 

  11. Mikami R, Shimada Y, Yotsumoto H (1977) Microangiopathy in sarcoidosis from the study of muscle biopsy. In: Japan Medical Research Foundation (eds) Vascular lesions of collagen diseases and related conditions. University of Tokyo Press, Tokyo, pp 236–246

    Google Scholar 

  12. Salomon MI, Tung PP, Kornad CH, Edward JK, Tchertkoff V (1975) Membranous glomerulopathy in a patient with sarcoidosis. Arch Pathol 99: 479–483

    Google Scholar 

  13. Waldek S, Agius-Ferrante AM (1978) Renal failure due to glomerulonephritis in sarcoidosis. Br Med J 1–6120, 1110 1111

  14. Lee SM, Michael AF (1978) Focal glomerular sclerosis and sarcoidosis. Arch Pathol Lab Med 102: 572–575

    Google Scholar 

  15. Chun MPKC, Hull S, Ball JH, Butkus DE (1980) Sarcoidosis associated with glomerulonephritis: Case report. Milit Med 145: 121–122

    Google Scholar 

  16. McCoy QC, Tisher CC (1972) Glomerulonephritis associated with sarcoidosis. Am J Pathol 68: 339–358

    Google Scholar 

  17. Ryujin Y, Mikami R, Dohi K, Yoneda S, Hiraga Y, Kobayashi F (1985) Renal involvement in sarcoidosis: Granuloma and glomerulopathy (abstract). Sarcoidosis 2: 65

    Google Scholar 

  18. Huzly A, Hoffmans A, Seidel H, Grimminger A, Hausser R, Arold C, Forschbach G (1963) Les bronches dans la sarcoidose. Bronches 13: 531–558

    Google Scholar 

  19. Hiraga Y, Kikuchi K, Yamamoto A (1986) Fluorescent bronchial angiography in sarcoidosis. Ann Ny Acad Sci 465: 731–737

    Google Scholar 

  20. Tamura S, Kumazaki S, Tsuzuki N, Nonaka T, Uzawa T, Mori Y (1985) Capillary Lesions in pulmonary sarcoidosis (abstract). Sarcoidosis 2: 68

    Google Scholar 

  21. Matsui Y, Iwai K, Tachibana T, Fruie T, Shigematsu N, Izumi T, Homma H, Mikami R, Hongo O, Hiraga Y, Yammamoto Y (1976) Clinicopathological study on fatal myocardial sarcoidosis. Ann NY Acad Sci 278: 455–469

    Google Scholar 

  22. Fleming HA (1980) Sarcoid heart disease—a review and an appeal. Thorax 35: 641–643

    Google Scholar 

  23. Sekiguchi M, Numao Y, Imai M, Furuie T, Mikami R (1980) Clinical and histopathological profile of sarcoidosis of the heart and acute idiopathic myocarditis. Concepts through a study employing endomyocardial biopsy: I. Sarcoidosis. Jpn Circ J 44: 249–263

    Google Scholar 

  24. Sekiguchi M, Nagao H, Kaneko M, Hiroe M, Hirosawa K, Yamane K, Matsui Y, Iwai K (1985) Detection of basal lamina layering of the capillaries in the heart muscle in cases with sarcoidosis (abstract). Sarcoidosis 2: 65

    Google Scholar 

  25. Vracko R (1973) Basal lamina layering in diabetes mellitus. Evidence for accelerated rate of cell death and cell regeneration. Diabetes 23: 94–104

    Google Scholar 

  26. Boeck C (1899) Multipelt benignt hudsarkoid (Multiple benign skin sarcoid.) Norsk Mag Laegevid 14: 1321–1334

    Google Scholar 

  27. Bernstein M, Konzlemann FW, Sidlick DM (1928) Boeck's report of a case with visceral involvement. Arch Int Med 44: 721–734

    Google Scholar 

  28. Bottcher E (1959) Disseminated sarcoidosis with a marked granulomatous arteritis. Arch Pathol 68: 419–429

    Google Scholar 

  29. Michaels L, Brown NJ, Cory-Wright M (1960) Arterial changes in pulmonary sarcoidosis. Arch Pathol 69: 741–749

    Google Scholar 

  30. Thompson JR (1967) Vascular changes in sarcoidosis. Dis Chest 50: 357–361

    Google Scholar 

  31. Judd PA, Finnegan P, Curran RC (1974) Pulmonary sarcoidosis: A clinico-pathological study. J Pathol 115: 191–197

    Google Scholar 

  32. Carrington CB, Gaensler EA, Mikus JP, Schachter AW, Burke GW, Goff AM (1976) Structure and function in sarcoidosis. Ann NY Acad Sci 278: 265–283

    Google Scholar 

  33. Meyer TS, Foley JM, Campagna-Pinto D (1953) Granulomatous angiitis of the meninges in sarcoidosis. Arch Neurol Psychol 69: 587–600

    Google Scholar 

  34. Schourap K, Vimtrup B (1956) Sudden natural death caused by haemoptysis in Boeck's sarcoid; a case report. Acta Med Leg Soc 9: 216

    Google Scholar 

  35. Reed R, Rubnitz ME, Toigo A (1964) Hemoptysis in sarcoidosis. Report of a case. Dis Chest 46: 241–244

    Google Scholar 

  36. Rosen Y, Moon S, Huang C, Gourin A, Lyons HA (1977) Granulomatous pulmonary angiitis in sarcoidosis. Arch Pathol Lab Med 101: 170–174

    Google Scholar 

  37. Liebow AA (1973) Pulmonary angiitis and granulomatosis. Am Rev Respir Dis 108: 1–8

    Google Scholar 

  38. Churg A, Carrington CB, Gupta R (1979) Necrotizing sarcoid granulomatosis. Chest 76: 406–413

    Google Scholar 

  39. Fuse U, Shimada Y, Yamamoto M (1977) Microangiopathy of sarcoidosis. J National Defence Medical College 2: 49–53

    Google Scholar 

  40. Wanstrup J, Christensen HE (1966) Sarcoidosis: I. Ultrastructural investigations on epithelioid cell granulomas. Acta Pathol Microbiol Scand 66: 169

    Google Scholar 

  41. Gardner-Throp C (1972) Muscle weakness due to sarcoid myopathy. Six cases reports and evaluation of steroid therapy. Neurology 22: 917–928

    Google Scholar 

  42. Kalifat SR, Bonteille M, Delarue J (1969) Changes in connective in sarcoid granuloma. Hyalin, paramyloid and fibrinoid. Electron microscopic study of 11 cases. Virchows Arch 3: 348–358

    Google Scholar 

  43. Soler P, Basset F, Bernaudin JF, Chretien J (1976) Morphology and distribution of the cells of a sarcoid granuloma: Ultrastructural study of serial sections. Ann NY Acad Sci 278: 147–159

    Google Scholar 

  44. Ghose T, Landrigan P, Asif A (1974) Localization of immunologlobulin and complement in pulmonary sarcoid granulomas. Chest 66: 264–268

    Google Scholar 

  45. Okabe T, Takaku F (1986) A macrophage factor that stimulate the proliferation of vascular endothelial cells. Biochem Biophys Res Commun. 134: 344–350

    Google Scholar 

  46. Katz S (1983) Clinical presentation and natural history of sarcoidosis. In: Fanbury BL (ed) Sarcoidosis and other granulomatous disease of the lung. Dekker, New York, pp 3–36

    Google Scholar 

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Authors and Affiliations

  1. Olinical Research Center for Rheumato-Allergology, National Sagamihara Hospital, 228, Sagamihara, Japan

    Riichiro Mikami

  2. The Heart Institute of Japan, Tokyo Women's Medical College, Tokyo, Japan

    Morie Sekiguchi

  3. Department of Internal Medicine, Nara Medical University, 634, Kashihara, Japan

    Yoshitada Ryuzin

  4. Department of Ophthalmology, Kudanzaka Hospital, Tokyo, Japan

    Fumiko Kobayashi

  5. Department of Respiratory Disease, Sapporo Hospital of Japanese National Railways, Sapporo, Japan

    Yomei Hiraga

  6. Department of Neurology, Kanto Rosai Hospital, Kawasaki, Japan

    Yukihiko Shimada

  7. Department of Internal Medicine, Shinshu University, Matsumoto, Japan

    Ichiro Mochizuki & Toshio Kobayashi

  8. Department of Respiratory Disease, Kanto Teishin Hospital, Tokyo, Japan

    Shizuo Tamura

  9. Radiation Effects Research Foundation, Hiroshima, Japan

    Yutaka Hosoda

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  1. Riichiro Mikami
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  2. Morie Sekiguchi
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  3. Yoshitada Ryuzin
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  4. Fumiko Kobayashi
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  5. Yomei Hiraga
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  6. Yukihiko Shimada
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  7. Ichiro Mochizuki
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  8. Toshio Kobayashi
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  9. Shizuo Tamura
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  10. Yutaka Hosoda
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Mikami, R., Sekiguchi, M., Ryuzin, Y. et al. Changes in the peripheral vasculature of various organs in patients with sarcoidosis—Possible role of microangiopathy. Heart Vessels 2, 129–139 (1986). https://doi.org/10.1007/BF02128138

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  • DOI: https://doi.org/10.1007/BF02128138

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