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Melanocytes and melanosis of the oesophagus in Japanese subjects — analysis of factors effecting their increase

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Summary

Normal oesophagus specimens taken from 65 autopsy cases and surgical specimens from 127 oesophageal carcinoma cases were examined histopathologically to determine melanocyte incidence and distribution. Melanocytes were found in the epithelio-stromal junction in 7.7% of normal oesophagus specimens examined at autopsy, and in 29.9% of surgical cases with oesophageal carcinoma. Positive specimens in the latter groups, especially from pre-operatively irradiated individuals, showed a more remarkable increase of melanocytes than was evident in any of the normal oesophageal samples. There were no significant differences in incidence between males and females, or between age groups. In cases where the cancer invaded into deeper stroma, the melanocytes were mainly observed in the normal epithelium around the carcinomas. Epithelial and stromal elements of the melanotic mucosa commonly showed hyperplastic changes such as acanthosis or basal cell hyperplasia, and chronic oesophagitis. Melanocytes were observed most commonly in the lower part of the oesophagus, the site where malignant melanoma of the oesophagus, most often originates. These results strongly suggest that the melanocyte increase observed in areas of hyperplastic epithelium and chronic oesophagitis may play an important role as a precursor lesion for malignant melanoma in the oesophagus.

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References

  • Baur E (1906) Ein Fall von primarem Melanom des Osophagus. Arb Anat Inst Tübingen 5:343–354

    Google Scholar 

  • Becker SW (1927) Melanin pigmentation: a systemic study of the pigment of human skin and upper mucous-membrane with special consideration of pigmented dendritic cells. Arch Dermatol Syphilol 16:259

    Google Scholar 

  • Bullock WK, Thompson HL, Gregory G (1953) Primary melanocarcinoma of esophagus; third histologically proven case. Cancer 6:578–580

    CAS  PubMed  Google Scholar 

  • Clark WH, Forberg R, Ainworth AM (1979) Tumor progression in primary human cutaneous malignant melanoma. In: Clark WH, Goldman LI, Mastrangelo MJ (eds) Human malignant melanoma. Grune & Stratton, New York, pp 15–31

    Google Scholar 

  • Cramer SF (1984) The neoplastic development of malignant melanoma. Am J Dermatopathol 6 [Suppl]: 299–308

    Google Scholar 

  • DiConstazo DP, Urmacher C (1987) Primary malignant melanoma of the esophagus. Am J Surg Pathol 11:46–52

    Google Scholar 

  • Gordon PR, Mansur GP, Gilchrest BA (1989) Regulation of human melanocyte growth, dendricity, and melanization by keratinocyte derived factors. J Invest Dermatol 92:565–572

    CAS  PubMed  Google Scholar 

  • Haraban R, Ghosh S, Baird A (1987) bFGF is the putative natural growth factor for human melanocytes. In Vitro Cell Dev Biol 23:47–52

    Google Scholar 

  • Johnson EP (1910) The development of mucous membrane of the esophagus, stomach, and small intestine in the human embryo. J Anat 10:251

    Google Scholar 

  • Kanno J, Matsubara O, Kasuga T (1986) Histogenesis of the intradermal melanocytic tumor in BDF1 mice induced by topical application of DMBA and TPA. Acta Pathol Jpn 36:1–14

    CAS  PubMed  Google Scholar 

  • Kanno J, Matsubara O, Kasuga T (1987) Induction of melanosis in Schwann cell and perineural epithelium by DMBA and TPA. Acta Pathol Jpn 37:1297–1304

    CAS  PubMed  Google Scholar 

  • Kasuga T (1987) Characterization of malignant melanoma in Japan. VIII Asia Pacific Cancer Conference. (Abstruct), p 128

  • Kreuser ED (1979) Primary malignant melanoma of the esophagus. Virchows Arch [A] 385:49–59

    Article  CAS  Google Scholar 

  • LaPava S, Nigogosyan G, Pickren JW, Cabrera A (1963) Melanosis of the esophagus. Cancer 16:48–50

    Google Scholar 

  • Miyazaki H, Kawada A, Takaki Y, Sato T, Masutani M (1974) Effects of ultraviolet light on epidermal dendritic cells of hairless mice. In: Pathak MA, Harber LC, Seiji M, Kukita A (eds) Sunlight and man. Tokyo University Press, Tokyo, pp 217–229

    Google Scholar 

  • Mori W (1979) A geo-pathological study on malignant melanoma in Japan. Pathol Microbiol 37:169–180

    Google Scholar 

  • Nakai T, Rappaport H (1963) A study of histogenesis of experimental melanotic tumor resembling cellular nevi. Am J Pathol 34:615–625

    Google Scholar 

  • Paul E (1984) Malignant melanoma and nevocellular nevi. Thieme, Stuttgart, pp 1–5

    Google Scholar 

  • Piccone VA, Klopstick R, LeVeen HH, Sika J (1970) Primary malignant melanoma of the esophagus associated with melanosis of the entire esophagus. J Thorac Cardiovasc Surg 59:864–870

    CAS  PubMed  Google Scholar 

  • Raven RW, Dawson I (1964) Malignant melanoma of the esophagus. Br J Surg 51:551–555

    CAS  PubMed  Google Scholar 

  • Rosdahl IK, Szabo G (1978) Mitotic activity of epidermal melanocytes in UV-irradiated mouse skin. J Invest Dermatol 70:143–148

    Article  CAS  PubMed  Google Scholar 

  • Shibata T (1973) Distribution of human melanocytes in the stratified squamous epithelium of mucosa (in Japanese). Ochanomizu Med J 21:87–96

    Google Scholar 

  • Stout AP, Lattes R (1957) Tumors of the esophagus. In: Atlas of tumor pathology, sect. V, fasc. 20. Armed Forces Institute of Pathology, Washington, D.C., p 104

    Google Scholar 

  • Tanaka K (1988) Quantitative and morphological study of melanocytes based on kinetics of melanosome in epidermal proliferating lesions (in Japanese). Ochanomizu Med J 36:125–139

    Google Scholar 

  • Tateishi R, Taniguchi H, Wada A, Horai T, Taniguchi K (1974) Argyrophil cells and melanocytes in esophageal mucosa. Arch Pathol 98:87–89

    CAS  PubMed  Google Scholar 

  • Uehara T, Matsubara O, Kasuga T (1987) Melanocytes in the nasal cavity and paranasal sinus. Acta Pathol Jpn 37:1105–1114

    CAS  PubMed  Google Scholar 

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Ohashi, K., Kato, Y., Kanno, J. et al. Melanocytes and melanosis of the oesophagus in Japanese subjects — analysis of factors effecting their increase. Vichows Archiv A Pathol Anat 417, 137–143 (1990). https://doi.org/10.1007/BF02190531

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  • DOI: https://doi.org/10.1007/BF02190531

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