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Delayed hypersensitivity reactions in the gastrointestinal tract

IV. Effects of chronicity, neostigmine, adjuvant, and endotoxin on the pig colon lesion

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Abstract

Nineteen niniature swine were skin-sensitized to 2–4 dinitrochlorobenzene (DNCB) and had a colostomy in the midtransverse colon. All were given DNCB in adhesive paste 3 times weekly for 6 months, through the colostomy. In addition 6 animals received Freund's complete adjuvant, 6 were given E. coli endotoxin, and 4 were given neostigmine 2 times weekly for 6 months. The morphological changes produced in all animals were those of microscopic ulceration and partial glandular destruction. The lamina propria showed a chronic inflammatory infiltrate. The vessels showed perivascular congestion. The adjuvant group seemed to have a more grossly intense lesion. In the neostigmine group, crypt abscesses were found in all pigs, the first production of such lesions in an experimental model.

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Authors and Affiliations

  1. From the Departments of Medicine and Pathology, University of Tennessee College of Medicine and the Veterans Administration Hospital, Memphis, Tenn

    Richard O. Bicks MD, G. F. Bale MD, Julio Goldenberg MD, E. William Rosenberg MD, Craig Hair & Martha Patterson

Authors
  1. Richard O. Bicks MD
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  2. G. F. Bale MD
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  3. Julio Goldenberg MD
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  4. E. William Rosenberg MD
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  5. Craig Hair
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  6. Martha Patterson
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Additional information

Supported by Grant 09384 from the National Institute of Arthritis and Metabolic Diseases, US Public Health Service.

Thanks are due Dr. Wolcott G. Dunham, Mr. James Banks, and their staff, Memphis Veterans Hospital, for their assistance.

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Bicks, R.O., Bale, G.F., Goldenberg, J. et al. Delayed hypersensitivity reactions in the gastrointestinal tract. Digest Dis Sci 14, 853–863 (1969). https://doi.org/10.1007/BF02233206

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  • DOI: https://doi.org/10.1007/BF02233206

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