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L-dopa improves colour vision in Parkinson's disease

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

In recent studies disorders of colour vision in Parkinsonian patients have been demonstrated. Up to now, the influence of dopaminergic treatment on those phenomena remains unclear. We therefore performed a colour vision test (Farnsworth-Munsell 100 Hue Test) in 19 patients with Parkinson's disease before and aater the oral application of the morning dose of L-dopa. The colour discrimination was significantly improved after the ingestion of L-Dopa. There was no different effect of L-Dopa on the blue-yellow or red-green axis of colour vision. The morphological structures responsible for these colour vision disturbances are unknown, but it can be concluded that the dopamine deficiency in Parkinson's disease is not restricted to the basal ganglia but may involve the visual system as well.

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References

  • American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders 3rd edn, revised. APA, Washington DC, USA

    Google Scholar 

  • Beck AT, Ward CJ, Mendelsohn M, Mock H, Erbaugh J (1961) An inventary for measuring depression. Arch Gen Psychiatry 4: 561–571

    Google Scholar 

  • Bodis-Wollner I, Yahr M (1978) Measurement of visual evoked potentials in Parkinson's disease. Brain 101: 661–671

    Google Scholar 

  • Bodis-Wollner I, Marx MC, Mitra S, Bobak P, Mylin L, Yahr M (1987) Visual dysfunction in parkinson's disease. Loss in spatiotemporal contrast sensitivity. Brain 110: 1675–1698

    Google Scholar 

  • Bodis-Wollner I, Tagliati M (1993) The visual system in Parkinson's disease. Adv Neurol 60: 390–394

    Google Scholar 

  • Büttner Th, Kuhn W, Klotz P, Steinberg R, Langkafel M, Przuntek H (1992) Disorders of color perception in Parkinson's disease. J Neurol 239 [Suppl 3]: S4

    Google Scholar 

  • Büttner Th, Kuhn W, Klotz P, Steinberg R, Voss L, Bulgaru D, Przuntek H (1993) Disturbance of colour perception in Parkinson's disease. J Neural Transm [PD-Sec] 6: 11–15

    Google Scholar 

  • Bulens C, Meerwaldt JD, van der Wildt GJ (1988) Effect of stimulus orientation on contrast sensitivity in Parkinson's disease. Neurology 38: 76–81

    Google Scholar 

  • Contin M, Riva R, Martinelli P, Cortelli P, Albani F, Baruzzi A (1993) Pharmacodynamic modeling of oral levodopa: clinical application in Parkinson's disease. Neurology 43: 367–373

    Google Scholar 

  • Farnsworth D (1943) The Farnsworth-Munsell 100-Hue and dichotomous test for color vision. J Opt Soc Am 33: 568–578

    Google Scholar 

  • Gawel MJ, Das P, Vincent S, Clifford Rose F (1981) Visual and auditory evoked responses in patients with parkinson's disease. J Neurol Neurosurg Psychiatry 44: 227–232

    Google Scholar 

  • Harnois C, Di Paolo T (1990) Decreased dopamine in the retinas of patients with Parkinson's disease. Invest Ophtalmol Visual Sci 31: 2473–2475

    Google Scholar 

  • Hutton JT, Morris JL, Elias JW, Varma R, Poston JN (1991) Spatial contrast sensitivity ist reduced in bilateral Parkinson's disease. Neurology 41: 1200–1202

    Google Scholar 

  • Kinnear PR (1970) Proposals for scoring and assessing the 100-Hue-Test. Vision Res 10: 423–433

    Google Scholar 

  • Kramer SG (1971) Dopamine: a retinal neurotransmitter. I. Retinal uptake, storage, and light-stimulated release of H3-dopamine in vivo. Invest Ophtalmol Visual Sci 10: 438–452

    Google Scholar 

  • Kupersmith MJ, Shakin E, Siegel IM, Liebermann A (1982) Visual system abnormalities in patients with Parkinson's disease. Arch Neurol 39: 284–288

    Google Scholar 

  • Livingstone MS, Hubel DH (1984) Anatomy and physiology of a colour system in the primate visual cortex. J Neurosci 4: 309–356

    Google Scholar 

  • Mestre D, Blin O, Serratrice G, Pailhous J (1990) Spatiotemporal contrast sensitivity differs in normal aging and Parkinson's disease. Neurology 40: 1710–1714

    Google Scholar 

  • Montgomery Jr EB (1992) Pharmakokinetics and pharmakodynamics of levodopa. Neurology 42 [suppl 1]: 17–22

    Google Scholar 

  • Price MJ, Feldman RG, Adelberg D, Kayne H (1992) Abnormalities in color vision and contrast sensitivity in Parkinson's disease. Neurology 42: 887–890

    Google Scholar 

  • Regan D, Maxner C (1987) Orientation-selective visual loss in patients with Parkinson's disease. Brain 110: 415–432

    Google Scholar 

  • Smith VC, Pokorny J, Pass AS (1985) Color-Axis determination on the Farnsworth-Munsell 100-Hue Test. Am J Ophtalmol 100: 176–182

    Google Scholar 

  • Sollazzo D (1985) Influence of L-Dopa/carbidopa on pattern reversal VEP: behavioural difference in primary and secondary parkinsonism. Electroencephalogr Clin Neurophysiol 61: 236–242

    Google Scholar 

  • Struck LK, Rodnitzki RL, Dobson JK (1990) Circadian fluctuations of contrast sensitivity. Neurology 40: 467–470

    Google Scholar 

  • Terziivanov D, Filipova M, Januk I, Balik J, Filip V, Stika L (1982) Changes in electroretinogram and serum potassium during L-Dopa treatment in parkinsonism. Arch Psychiatr Nervenkr 232: 507–513

    Google Scholar 

  • Verriest G, van Laethem J, Uvijls A (1982) A new assessment of the normal ranges of the Farnsworth-Munsell 100-Hue test scores. Am J Ophtamol 93: 635–642

    Google Scholar 

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Büttner, T., Kuhn, W., Patzold, T. et al. L-dopa improves colour vision in Parkinson's disease. J Neural Transm Gen Sect 7, 13–19 (1994). https://doi.org/10.1007/BF02252659

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  • DOI: https://doi.org/10.1007/BF02252659

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