Abstract
Fifty children between 3 months postnatal and 16 years of age were examined by means of a 1.5 T superconductive magnet, run at 0.35 and 1.0 T. The myelination was studied qualitatively and quantitatively (relaxation times, proton densities, image contrast). With increasing age, a decrease of T1 and proton density of white matter was found, which was complete at one year of age. In regions with a slow progression of myelination, gray/white matter contrast showed an increase up to the end of the first decade. Pathological white matter maturation was diagnosed either as an abnormal transformation of myelin (characterized by abnormal relaxation values), or as a deficient or delayed myelin formation (in comparison with age-matched controls).
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Yakovlev PI, Lecours AR (1967) The myelogenetic cycles of regional maturation of the brain. In: Minkowski A (ed) Regional development of the brain in early life. Blackwell, Oxford, pp 3–65
Johnson MA, Pennock JM, Bydder GM, Steiner RE, Thomas DJ, Hayward R, Bryant DRT, Payne JA, Levene MI, Whitelaw A, Dubowitz LMS, Dubowik V (1983) Clinical NMR imaging of the brain in children. AJR 141: 1005
Holland BA, Haas DK, Norman D, Brant-Zawadzki M, Newton TG (1986) MRI of normal brain maturation. AJNR 7: 201
Ortendahl DA, Hylton N, Kaufman L, Watts JC, Crooks LE, Mills CM, Stark DD (1984) Analytical tools for magnetic resonance imaging. Radiology 153: 479
Wehrli FW, MacFall JR, Shutts D, Breger R, Herfkens R (1984) Mechanisms of contrast in NMR imaging. J Comput Assist Tomogr 8: 369
Baierl P, Seiderer M, Heywang S, Rath M (1986) Das Kontrastrauschverhältnis als Maß für den Gewebekontrast in der Kernspintomographie. Digitale Bilddiagn 6: 101
Dobbing J, Sands J (1973) Quantitative growth and development of human brain. Arch Dis Child 48: 757
Brant-Zawadzki M, Enzmann DR (1981) Using computed tomography of the brain to correlate low white-matter attenuation with early gestational age in neonates. Radiology 139: 105
Quencer RM (1982) Maturation of normal primate white matter: computed tomographic correlation. AJNR 3: 365
Kamman RL, Go KG, Muskiet FAJ, Stomp GP, van Dijk P, Berendsen HJC (1984) Proton spin relaxation studies of fatty tissue and cerebral white matter. Magn Reson Imaging 2: 211
Chattha AS, Richardson EP (1977) Cerebral white-matter hypoplasia. Arch Neurol 34: 137
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Baierl, P., Förster, C., Fendel, H. et al. Magnetic resonance imaging of normal and pathological white matter maturation. Pediatr Radiol 18, 183–189 (1988). https://doi.org/10.1007/BF02390391
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DOI: https://doi.org/10.1007/BF02390391