Abstract
Objective: To evaluate retrospectively the importance of invasion beyond the basement membrane on overall survival in Fallopian tube carcinoma and its influence on the necessity of postoperative adjuvant therapy (stage 0 vs. stage I).Design: In a nationwide analysis the data of 51 patients were evaluated. The participating departments provided the study center with histologic specimens. A re-staging was done according to the FIGO-classification for Fallopian tube carcinomas. Stage 0 patients received no further postoperative therapy, in stage I patients were devided in 2 groups to evaluate the impact of postoperative adjuvant therapy (chemotherapy vs. irradiation).Results: Patients of stage 0 had a significantly better prognosis than patients of stage I (p=0.035). Stage I patients treated by irradiation showed a significantly better prognosis than patients treated by chemotherapy (p=0.017).Conclusion: Tumour penetration through the basement membrane causes prognosis to deteriorate significantly (5-year survival rate about 50% in stage I). Postoperative therapy is thus indicated with stage I disease. Irradiation seems to give better results than chemotherapy.
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Members of the Study Group: G. Alpi, Ch. Altmutter, G. Bartussek, M. Bayr, H. Becker, B. Bibus, A. Bichler, K. Czerwenka, H. P. Dinges, W. Feigl, A. Fink, F. Friedrich, F. Fuith, E. Georgiades, H. Gogl, W. Grünberger, A. Hackl, K. Kahn, S. Karasegh, A. Kerak, D. Kosak, H. Krahuletz, A. Kratochwil, J. Kremser, L. Leodolter, E. Machacek, H. Mayer, M. Medl, S. Naude, H. Nemec, R. Pavelka, W. Pflanzl, H. Salzer, E. Schenk, A. Schröck, A. Seidl, M. Stiglbauer, W. Stiglbauer, St. Szalay, R. Taschner, J. Tscharf, A. Wellenhofer, W. Winfried, N. Wirrani, G. Wolfram.
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Klein, M., Rosen, A., Graf, A. et al. Primary Fallopian tube carcinoma — a retrospective survey of 51 cases. Arch Gynecol Obstet 255, 141–146 (1994). https://doi.org/10.1007/BF02390941
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DOI: https://doi.org/10.1007/BF02390941