Summary
It has previously been observed that after the third decade of life the tensile strength of bone decreases faster than its density [1], indicating that some microstructural change occurs in bone with advancing age. In order to try to elucidate this observation, the orientation and particle size of the mineral phase of bone have been studied with respect to age. Samples were taken from femora varying in age from 13 to 97 years. The results show that the degree of preferred orientation does not vary with age after the first decade of life. However, the percentage of small particles increased up to the fourth decade of life and thereafter decreased, a pattern of change similar to that observed for bone strength. It would seem to indicate that an increase in mineral particle size is a factor that contributes to the loss of bone strength and that an increased percentage of large particles in the later years of life could, along with osteoporosis, help to explain the increased fragility in the bones of the elderly.
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Wall, J. C., Chatterji, S., Jeffery, J. W.: Age related changes in density and strength of human femoral cortical bone, Calcif. Tissue Int.27:105–108, 1979
Knowelden, J., Buhr, A. J., Dumbar, D.: Incidence of fracture in persons over 30 years of age, Br. J. Prev. Soc. Med.18:130–141, 1964
Nilsson, B. E. R., Smith, R. E.: The influence of breaking force of osteoporosis following fracture of the tibial shafts in rats, Acta Orthop. Scand.40:72–78, 1969
Ascenzi, A., Bonucci, E.: The tensile properties of single osteons, Anat. Rec.158:375–386, 1967
Vincentelli, R., Evans, F. G.: Relations among mechanical properties, collagen fibres and calcification in adult human cortical bone, J. Biomech.4:193–201, 1971
Stuhler, R.: Über den Feinbau des Knochens. Eine Röntgen-Feinstruktur-Untersuchung. Fortschr. Gebiete Röntgenol.57:231, 1938
Bernard, G. W.: The ultrastructural interface of bone crystals and organic matrix in woven and lamellar endochondral bone, J. Dent. Res. [Suppl.]48:781–788, 1969
Eanes, E. D., Possner, A. S.: In H. Brumberger (ed.): Small-angle x-ray scattering. Gordon and Breach Science Publishers, London, 1967
Robinson, R. A., Watson, M. L.: Collagen-crystal relationships in bone as seen in the electron microscope, Anat. Rec.114:383–410, 1952
Bocciarelli, D. S.: Morphology of crystallites in bone, Calcif. Tissue Res.5:261, 1970
Towe, K. M., Hamilton, G. H.: Ultra-microtome-induced deformation artefacts in densely calcified material, J. Ultrastruct. Res.22:274–281, 1968
Chatterji, S., Jeffery, J. W., Whitney, N.: The mechanics of failure of plaster of Paris blocks in different types of stress, Cement Technol.1:1–3, 1970
Chatterji, S.: Load bearing structures and crystal intergrowth, Nature252:383, 1974
Chatterji, S., Jeffery, J W.: Changes in structure in human bone with age, Nature219:482–484, 1968
Wall, J. C., Chatterji, S., Jeffery, J. W.: Human femoral cortical bone: a preliminary report on the relationship between strength and density, Med. Biol. Eng. Comput.10:673–677, 1972
Wall, J. C., Chatterji, S.: Technical note: grips for holding small sample of bone during tensile testing, Med. Biol. Eng. Comput.13:309–310, 1975
Chatterji, S., Moore, N., Jeffery, J. W.: Preparation of non-conducting samples for scanning electron microscopy, J. Phys. E.5:118–119, 1972
Chatterji, S., Wall, J. C., Jeffery, J. W.: Changes in the degree of orientation of bone materials with age in the human femur, Experientia28:156–157, 1972
Chatterji, S.: Formation of polycrystalline aggregates in mineral and biological systems, Experientia30:252, 1974
Fenandez-Morgan, H., Engstrom, A.: Electron microscopy and X-ray diffraction of bone, Biochem. Biophys. Acta23:260, 1957
Johansen, E., Parks, H. F.: Electron microscopic observations on the three-dimensional morphology of apatite crystallites in human dentine and bone, J. Biophys. Biochem. Cytol.7:743–746, 1960
DeHoff, R. T., Rhines, F. N.: Quantitative Microscopy. McGraw-Hill, New York, 1968
Pope, M. H., Outwater, J. O.: The fracture characteristics of bone substance, J. Biomech.5:457–465, 1972
Ascenzi, A., Bonucci, E., Bocciarelli, D. S.: An electron microscope study of osteon calcification, J. Ultrastruct. Res.12:287–303, 1965
Grynpas, M.: The crystallinity of bone mineral, J. Mater. Sci.11:1691–1696, 1976
Swanson, S. A. V.: Biomechanical characteristics of bone, Adv. Biomed. Eng.1:137, 1971
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Chatterji, S., Wall, J.C. & Jeffery, J.W. Age-related changes in the orientation and particle size of the mineral phase in human femoral cortical bone. Calcif Tissue Int 33, 567–574 (1981). https://doi.org/10.1007/BF02409493
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DOI: https://doi.org/10.1007/BF02409493