Abstract
Specimens from 235 surgically treated cases of gastric cancer were examined for venous invasion in order to investigate its clinical significance. A total of 87 (37.0 per cent) cases showed histologic evidence of venous invasion, with the incidence being 48.3 per cent of 180 cases, after the exclusion of 55 cases where cancerous invasion was limited to the mucosa. The frequency of venous invasion varied with the gross type of tumor, the depth of penetration and the degree of differentiation, being highest in tumors of type 2 and moderately differentiated adenocarcinoma. It increased proportionately dependeing upon the depth of penetration and the incidence increased in cases where there was evident lymphatic invasion or lymph node metastasis. The long term survival rate significantly decreased in patients with venous invasion when compared to those without it. In this report, we also discuss the marked difference in the incidence of liver metastasis between gastric and colorectal carcinomas in relation to venous invasion of the primary tumor. Double staining with Victoria blue and hematoxylin-eosin for elastic fibers proved useful for detecting venous invasion in the carcinomatous tissue, though endothelial markers have great specificity for differentiating small veins from lymphatics.
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Yokogawa K, Ohashi H, Kato H. Victoria blue-HE stain. Rinsho Kensa (J Med Technology) 1983; 27: 571–572. (in Japanese)
Mukai K, Rosai J, Burgdorf J. Localization of factor VIII related antigen in vascular endothelial cells using an immunoperoxidase method. Am J Pathol 1980; 4: 273–276.
Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study in surgery and pathology. Part 1 & 2. Jap J Surg 1981; 11: 127–139.
Borrmann R. Geschwulste des Magens: Handbuch der speziellen pathologischen Anatomie und Histologie (herausgegeben von Henke JU und Lubarsch O). IV/erster Teil, 864–871, Verlag von Julius Springer, 1926.
Harach HR, Jasani B, Williams ED. Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid. J Clin Pathol 1983; 36: 1050–1054.
Glichrist KW, Gould VE, Hirschl S, Imbriglis JE, Patchefsky AS, Penner DW, Pickren J, Schwartz IS, Weeler JE, Barnes JM, Mansour EG. Interobserver variation in the identification of breast carcinoma in intramammary lymphatics. Human Pathol 1982; 13: 170–173.
Yui S. Histological studies on the vascular lesions in the stomach with cancer. Ochanomizu Igakkai Zasshi 1957; 5: 88–107. (in Japanese with English Abst.)
Hamazaki M, Namba M, Fujita H, Fujii Y. Venous invasion in gastric cancer. Saiho Kaku Byorishi (J Karyopathol) 1967; 11: 107–112. (in Japanese)
Hamazaki M, Noguchi A, Furutani S, Motoyama Y, Nakamura A. Study on vascular invasion in advanced gastric carcinoma. Gan no Rinsho (Jap J Cancer Clin) 1973; 20: 311–316. (in Japanese with English Abst.)
Kitaoka H, Suemasu K, Hirota T. Adhesive forces between cells and liver metastasis in cases of gastric cancer. Gan no Rinsho (Jap J Cancer Clin) 1972; 18: 534–537. (in Japanese with English Abst.)
Nagatomo T, Murakami E. Clinicopathological studies on the blood vessel invasion due to tumor cells in gastric carcinoma. Gan no Rinsho (Jap J Cancer Clin) 1973; 19: 206–214. (in Japanese with English Abst.)
Nagao K, Matsuzaki W, Ide G, Onoda S, Isono K, Sato H. A clinicopathological analysis on vascular invasion in advanced cancer.— A diagnostic criteria for the vascular invasion of gastric cancer in relation to prognosis—. I to Cho (stomach & Intestine) 1975; 10: 677–684. (in Japanese with English Abst.)
Hanabusa N. Histochemical and electron microscopic studies on proliferation of connective tissue in gastric carcinoma. Okayama-Igakkai-Zasshi 1977; 89: 1049–1081. (in Japanese with English Abst.)
Cho S, Kataoka T, Kawamura K. A clinicopathological study on vascular invasion in progressive gastric cancer. Showa-Igakkai-Zasshi 1987; 47: 219–230. (in Japanese with English Abst.)
Inada K, Shimokawa K, Ikeda T, Hayashi M, Goto M. Clinicopathological study on venous invasion in colorectal carcinoma. Nippon Shokaki Geka Gakkai Zasshi (Jap J Gastroenterolog Surg) 1988; 21: 2278–2286. (in Japanese)
Talbot IC, Ritchie S, Leighton MH, Hughes AO, Bussey JR, Morson BC. The clinical significance of invasion of veins by rectal cancer. Br J Surg 1980; 67: 439–442.
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Inada, K., Shimokawa, K., Ikeda, T. et al. The clinical significance of venous invasion in cancer of the stomach. The Japanese Journal of Surgery 20, 545–552 (1990). https://doi.org/10.1007/BF02471011
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DOI: https://doi.org/10.1007/BF02471011