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Solubility of uric acid and monosodium urate

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Abstract

A comprehensive theoretical treatment of the factors governing the solubility of uric acid and monosodium urate is given. The various constants appearing in the treatment are evaluated as functions of temperature and ionic strength using both existing data and new experimental data. The solubility of uric acid increases with increasing pH, while the solubility of monosodium urate has a minimum near pH 7·7 at 37°C. The solubility product of monosodium urate increases with increasing ionic strength.

Sommaire

On donne un traîtement théorique compréhensif des facteurs régissant la solubilité de l'acide urique et du monourate de sodium. On évalue les constantes diverses paraissant dans le traîtement, en fonction de la température, de la force ionique, en faisant usage à la fois des données existantes et des données expérimentales. La solubilité de l'acide urique augmente avec l'augmentation du pH, alors que la solubilité du monourate de sodium a un minimum de près de pH 7,7 à 37°C. Le produit de solubilité du monourate de sodium augmente avec la force ionique.

Zusammenfassung

Eine umfassende theoretische Behandlung der Faktoren, die die Löslichkeit der Harnsäure und des Mono-Natriumurats beherrscht, wird angeführt. Die verschiedenen Konstanten in der Behandlung als Funktionen der Temperatur und ionischen Stärke werden mit der Verwendung von bestehenden und neu-experimentellen Daten ausgewertet. Die Löslichkeit von Harnsäure vermehrt sich mit wachsendem pH, während die Löslichkeit von Mono-Natriumurat ein Minimum in der Nähe von pH 7,7 bei 37°C hat. Das Löslichkeit-Produkt des Mono-Natriumurats vermehrt sich mit wachsender ionischer Stärke.

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Authors and Affiliations

  1. Chemical Engineering and Materials Science Departments, University of Southern California, 90007, Los Angeles, Calif., USA

    William R. Wilcox & Ali Khalaf

  2. Department of Medicine, University of California, Los Angeles, Calif., USA

    Alan Weinberger, Ian Kippen & James R. Klinenberg

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  1. William R. Wilcox
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  2. Ali Khalaf
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  3. Alan Weinberger
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  4. Ian Kippen
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  5. James R. Klinenberg
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Wilcox, W.R., Khalaf, A., Weinberger, A. et al. Solubility of uric acid and monosodium urate. Med. & biol. Engng. 10, 522–531 (1972). https://doi.org/10.1007/BF02474201

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  • DOI: https://doi.org/10.1007/BF02474201

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