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Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4

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Somatic Cell and Molecular Genetics

Abstract

We recently cloned genomic sequences containing the promoter region for the messenger RNA cap binding protein (eIF4E). As the rate-limiting step in translation, eukaryotic initiation factor 4E is important in cellular growth control. Using oligonucleotide primers specific for the promoter region in polymerase chain reactions (PCR), we amplified the human gene in a chromosome 4-specific human/rodent somatic cell panel. This panel mapped single copy genomic sequences for eIF4E in the region 4q21 to 4q25.

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Literature Cited

  1. Merrick, W.C. (1992).Microbiological Reviews 56: 291–315.

    PubMed  CAS  Google Scholar 

  2. Hershey, J.W. (1991).Ann. Rev. Biochem. 60:717–755.

    Article  PubMed  CAS  Google Scholar 

  3. Hiremath, L.S., Webb, N.R., and Rhoads, R.E. (1985).J. Biol. Chem. 260:7843–7849.

    PubMed  CAS  Google Scholar 

  4. Duncan, R., Milburn, S.C., and Hershey, J.W. (1987).J. Biol. Chem. 262:380–388.

    PubMed  CAS  Google Scholar 

  5. Sonenberg, N. (1994).Biochimie 76:839–841.

    Article  PubMed  CAS  Google Scholar 

  6. Smith, M.R., Jaramillo, M., Liu, Y.L., Dever, T.E., Merrick, W.C., Kung, H.F., and Sonenberg, N. (1990).New Biologist 2:648–654.

    PubMed  CAS  Google Scholar 

  7. Koromilas, A.E., Lazaris-Karatzas, A., and Sonenberg, N. (1992).Embo J. 11:4153–4158.

    PubMed  CAS  Google Scholar 

  8. Fagan, R.J., Lazaris-Karatzas, A., Sonenberg, N., and Rozen, R. (1991).J. Biol. Chem. 266:16518–16523.

    PubMed  CAS  Google Scholar 

  9. Rosenwald, I.B., Lazaris-Karatzas, A., Sonenberg, N., and Schmidt, E.V. (1993).Mol. Cell. Biol. 13:7358–7363.

    PubMed  CAS  Google Scholar 

  10. Lazaris-Karatzas, A., Montine, K.S., and Sonenberg, N. (1990).Nature 345:544–547.

    Article  PubMed  CAS  Google Scholar 

  11. Lazaris-Karatzas, A., and Sonenberg, N. (1992).Mol. Cell. Biol. 12:1234–1238.

    PubMed  CAS  Google Scholar 

  12. Kerekatte, V., Smiley, K., Hu, B., Smith, A., Gelder, F., and De Benedetti, A. (1995).International Journal of Cancer 64:27–31.

    Article  CAS  Google Scholar 

  13. Jones, R.M., Branda, J., Johnston, K.A., Polymenis, M., Gadd, M., Rustgi, A., Callanan, L., and Schmidt, E.V. (1996).Mol. Cell. Biol. 16:4754–4764.

    PubMed  CAS  Google Scholar 

  14. Pelletier, J., Brook, J.D., and Housman, D.E. (1991).Genomics 10:1079–1082.

    Article  PubMed  CAS  Google Scholar 

  15. Dorfman, J., Lazaris-Karatzas, A., Malo, D., Sonenberg, N., and Gros, P. (1991).Genomics 9:785–788.

    Article  PubMed  CAS  Google Scholar 

  16. NIGMS Cambden, NJ.

  17. Slaugenhaupt, S.A., Roca, A.L., Liebert, C.B., Altherr, M.R., Gusella, J.F., and Reppert, S.M. (1995).Genomics 27:355–357.

    Article  PubMed  CAS  Google Scholar 

  18. Eubanks, J.H., Altherr, M., Wagner-McPherson, C., McPherson, J.D., Wasmuth, J.J., and Evans, G.A. (1992)Genomics 12:510–516.

    Article  PubMed  CAS  Google Scholar 

  19. Waha, A., Rollbrocker, B., Wiestler, O.D., and von Deimling, A. (1996).Diagnostic Molecular Pathology 5:147–150.

    Article  PubMed  CAS  Google Scholar 

  20. Bigner, S.H., Mark, J., Mahaley, M.S., and Bigner, D.D. (1984).Hereditas 101:103–113.

    PubMed  CAS  Google Scholar 

  21. Mitelman, F. (1994).Catalog of Chromosome Aberrations in Cancer. Wiley-Liss, New York,pp. 4252.

    Google Scholar 

  22. Heim, S., and Mitelman, F. (1995).Cancer Cytogenetics. Wiley-Liss, New York,pp. 536.

    Google Scholar 

  23. Das, S., Kearney, L., Bower, M., Chaplin, T., Riley, J.H., Anand, R., and Young, B.D. (1992).Genes, Chromosomes and Cancer 5:244–251.

    Article  CAS  Google Scholar 

  24. Cimino, G., Nakamura, T., Gu, Y., Canaani, O., Prasad, R., Crist, W.M., Carroll, A.J., Baer, M., Bloomfield, C.D., Nowell, P.C., and et al. (1992).Cancer Res. 52:3811–3813.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Massachusetts General Hospital Cancer Center, Building 149, 13th Street, 02129, Charlestown, Massachusetts

    Robin M. Jones, John Branda & Emmett V. Schmidt

  2. The Children’s Service, Massachusetts General Hospital, Fruit Street, 02114, Boston, Massachusetts

    Robin M. Jones & Emmett V. Schmidt

  3. Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th Street, 02129, Charlestown, Massachusetts

    Marcy E. MacDonald

  4. Genomics and Structural Biology Group, Los Alamos National Laboratory, 87545, Los Alamos, New Mexico

    Michael R. Altherr

  5. Department of Pathology, Massachusetts General Hospital, Fruit Street, 02114, Boston, Massachusetts

    David N. Louis

Authors
  1. Robin M. Jones
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  2. Marcy E. MacDonald
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  3. John Branda
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  4. Michael R. Altherr
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  5. David N. Louis
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  6. Emmett V. Schmidt
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Jones, R.M., MacDonald, M.E., Branda, J. et al. Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4. Somat Cell Mol Genet 23, 221–223 (1997). https://doi.org/10.1007/BF02721373

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  • DOI: https://doi.org/10.1007/BF02721373

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