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Uraniosomes produced in cultured rabbit kidney cells by uranyl acetate

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Virchows Archiv B

Summary

Cultured rabbit kidney cells were exposed to uranyl acetate. This produced single-membrane-bound presumably lysosomal bodies (called ‘uraniosomes’) containing electron-dense crystals in the cultured cells. Similar crystalline deposits were seen in extracellular locations also. All uraniosomes and extracellular uranium deposits analyzed by electron-probe x-ray analysis were found to contain uranium, potassium, calcium and phosphorus. Traces of sulphur were detected in some but not all uraniosomes and extracellular uranium deposits.

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Ghadially, F.N., Lalonde, JM.A. & Yang-Steppuhn, S. Uraniosomes produced in cultured rabbit kidney cells by uranyl acetate. Virchows Archiv B Cell Pathol 39, 21–30 (1982). https://doi.org/10.1007/BF02892833

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  • DOI: https://doi.org/10.1007/BF02892833

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