Abstract
Our aim was to assess the feasibility and safety of laparoscopic distal pancreatectomy in an animate model. After developing the technique in acute animal experiments, laparoscopic distal pancreatectomy was performed in five young domestic pigs. Five trocars were used (2–10 mm, 2–12 mm, 1–11 mm) for video laparoscopic access to the peritoneal cavity. The operations were performed without complication in 62-95 min (mean±SEM, 77±7 min). Each animal tolerated oral feedings on the first postoperative day and subsequently gained 6–11 kg (10±2 kg) in the 4-7-week interval prior to sacrifice. Although there was a significant increase in serum amylase on the first postoperative day, this was associated with a comparable increase in hematocrit, possibly representing hemoconcentration. The weight of the laparoscopically resected pancreatic segment ranged from 16 to 36 g (19±2 g) while that of the pancreatic head at sacrifice was 13-29 g (21±3 g). At the time of sacrifice, there were few intraabdominal adhesions and no evidence of fluid collection or pancreatitis. The staple line across the body of the pancreas was grossly intact in all animals. We conclude that laparoscopic distal pancreatectomy in the porcine model is feasible and safe. It may therefore be possible to perform laparoscopic distal pancreatectomy in humans.
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Attwood SEA, Hill ADK, Murphy PG, Thornton J, Stephens RB (1992) A prospective randomized trial of laparoscopic versus open appendectomy. Surgery 112: 497–501
Clayman RV, Kavoussi LR, McDougall EM, Soper NJ, Figenshau RS, Chandhoke PS, Albala DM (1992) Laparoscopic nephrectomy: a review of 16 cases. Surg Laparosc Endosc 2: 29–34
Dallemagne B, Weerts JM, Jehaes C, Markiewicz S, Lombard R (1991) Laparoscopic Nissen fundoplication: preliminary report. Surg Laparosc Endosc 1: 138–143
Gagner M (1992) Letter to the editor: laparoscopic adrenalectomy in Cushing’s syndrome and pheochromocytoma. N Engl J Med 327: 1033
Katkhouda N, Mouiel J (1991) A new technique of surgical treatment of chronic duodenal ulcer without laparotomy by videocoelioscopy. Am J Surg 161: 361–364
Nagorney DM, Edis AJ (1981) A use for the stapler in pancreatic surgery. Am J Surg 142: 384–385
Phillips EH, Franklin M, Carroll BJ, Fallas MJ, Ramos R, Rosenthal D (1992) Laparoscopic colectomy. Ann Surg 216: 703–707
Soper NJ, Barteau JA, Clayman RV, Becich MJ (1991) Safety and efficacy of laparoscopic cholecystectomy using monopolar electrocautery in the porcine model. Surg Laparosc Endosc 1: 17–22
Soper NJ, Barteau JA, Clayman RV, Ashley SW, Dunnegan DL (1992) Comparison of early postoperative results for laparoscopic vs. standard open cholecystectomy. Surg Gynecol Obstet 174: 114–118
Traverso LW, MacFarlane SK (1987) Pancreatic juice in the peritoneal cavity: antibiotics or omental preservation prevent mortality. J Surg Res 43: 220–225
Traverso LW, MacFarlane SK (1987) Pancreas autotransplantation-unsuitability of the swine as a model. Transplantation 44: 50
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Soper, N.J., Brunt, L.M., Dunnegan, D.L. et al. Laparoscopic distal pancreatectomy in the porcine model. Surg Endosc 8, 57–61 (1994). https://doi.org/10.1007/BF02909495
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DOI: https://doi.org/10.1007/BF02909495