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T-cell antigen receptors in rheumatoid arthritis

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Abstract

Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by chronic inflammation mainly in the joints. Several lines of evidence suggest that T cells are involved in the pathogenesis of the disease. RA is associated with certain HLA-DR alleles. Studies analyzing T-cell receptor transcripts in RA have found biased or preferential usage of certain Vα and/or Vβ gene segments by T cells infiltrating the synovial membrane or extravasating into the synovial fluid compared to peripheral blood. In certain patients few T-cell antigen receptor (TCR) clones dominated the infiltrating T cells, suggesting that T cells from the synovial membrane or the synovial fluid comprise oligoclonal populations of T cells. However, other studies have found a polyclonal population of T cells. In interpreting these results the phase of the disease (early vs. late RA), the source of T cells and the limitations of the methods used in these studies should be taken into consideration. However, it appears that synovial T cells comprise oligoclonal populations of T cells and that there is a bias towards particular TCR gene segments, although a specific TCR gene segment in RA has not emerged.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Temple University School of Medicine, 3400 North Broad Street, 19140, Philadelphia, Pa., USA

    Lazaros I. Sakkas & Chris D. Platsoucas

  2. Division of Hematology, University of Texas Health Science Center Medical School at Houston, Houston, Tex., USA

    Pei-Feng Chen

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  1. Lazaros I. Sakkas
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This work was supported in part by grant AR41003 from the National Institutes of Health.

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Sakkas, L.I., Chen, PF. & Platsoucas, C.D. T-cell antigen receptors in rheumatoid arthritis. Immunol Res 13, 117–138 (1994). https://doi.org/10.1007/BF02918273

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