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Central nervous system binding sites for calcitonin and calcitonin gene-related peptide

  • Basic Molecular Aspects of Synaptic Plasticity
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Abstract

Alternative splicing of the primary RNA transcript of the calcitonin gene leads to the generation of two distinct peptides, calcitonin (CT) and calcitonin gene-related peptide (CGRP). These peptides share only limited sequence homology and generally subserve different biological functions through their own distinct binding sites, which differ in specificity and distribution. Additionally, a binding site with high-affinity binding for both peptides that has a restricted pattern of distribution has been identified. The present article reviews the biochemical and morphological characteristics of central CT and CGRP binding, sites.

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Abbreviations

3V:

Third ventricle

4V:

Fourth ventricle

ac:

Anterior commissure

AcbC:

Accumbens nucleus, core

AcbSh:

Accumbens nucleus, shell

ACo:

Anterior cortical amygdaloid nucleus

acp:

Anterior commissure, posterior part

AD:

Anterodorsal thalamic nucleus

AHiAL:

Amygdalohippocampal area, anterolateral part

AHP:

Anterior hypothalamic area, posterior part

AM:

Anteromedial thalamic nucleus

AMPO:

Anterior medial preoptic nucleus

AP:

Area postrema

Arc:

Arcuate hypothalamic nucleus

AV:

Anteroventral thalamic nucleus

BIC:

Nucleus of the brachium of the inferior colliculus

BLa:

Basolateral amygdaloid nucleus, anterior part

BLV:

Basolateral amygdaloid nucleus, ventral part

BM:

Basomedial amygdaloid nucleus

BMA:

Basomedial amygdaloid nucleus, anterior part

bp:

Brachium pontis (stem of middle cerebellar peduncle)

BST:

Bed nucleus of the stria terminalis

BSTL:

Bed nucleus of the stria terminalis, lateral division

CA1–4:

Fields CA1–4 of Ammon's horn

cc:

Corpus callosum

Ce:

Central amygdaloid nucleus

CG:

Central (periaqueductal) gray

CGD:

Central gray (dorsal part)

CGL:

Central gray (lateral part)

cl:

Claustrum

CLi:

Caudal linear nucleus of the raphe

CM:

Central medial thalamic nucleus

CM:

Central medial thalamic nucleus

cp:

Cerebral peduncle, basal part

CPu:

Caudate putamen

Cu:

Cuneate nucleus

DEn:

Dorsal endopiriform nucleus

DG:

Dentate gyrus

DLG:

Dorsal lateral geniculate nucleus

DMTg:

Dorsomedial tegmental area

DpG:

Deep gray layer of the superior colliculus

DpMe:

Deep mesencephalic nucleus

DR:

Dorsal raphe nucleus

DTg:

Dorsal tegmental nucleus

dtgx:

Dorsal tegmental decussation

EW:

Edinger-Westphal nucleus

f:

Fornix

fi:

Fimbria of the hippocampus

fmj:

Forceps major of the corpus callosum

fr:

Fasciculus retroflexus

FStr:

Fundus striati

GP:

Globus pallidus

Gr:

Gracile nucleus

HDB:

Nucleus of the horizontal limb of the diagonal band

Hil:

Hilus of the dentate gyrus

ic:

Internal capsule

IC:

Inferior colliculus

ICjM:

Islands of Calleja, major island

Ing:

Intermediate gray layer of the superior colliculus

IO:

Inferior olive

IP:

Interpeduncular nucleus

La:

Lateral amygdaloid nucleus

LA:

Lateral amygdaloid nucleus

LD:

Laterodorsal thalamic nucleus

LDTg:

Laterodorsal tegmental nucleus

LH:

Lateral hypothalamic area

LHb:

Lateral habenular nucleus

lo:

Lateral olfactory tract

LP:

Lateral posterior thalamic nucleus

LRt:

Lateral reticular nucleus

LSD:

Lateral septal nucleus, dorsal part

LSI:

Lateral septal nucleus, intermediate part

LSV:

Lateral septal nucleus, ventral part

LV:

Lateral ventricle

mcp:

Middle cerebellar peducle

MD:

Mediodorsal thalamic nucleus

MdD:

Medullary reticular nucleus, dorsal part

MdV:

Medullary reticular nucleus, ventral part

Me:

Medial amygdaloid nucleus

Me5:

Mesencephalic trigeminal nucleus

MG:

Medial geniculate nucleus

MHb:

Medial habenular nucleus

MiTg:

Microcellular tegmental nucleus

ml:

Medial lemniscus

mlf:

Medial longitudinal fasciculus

MnR:

Median raphe nucleus

Mo5:

Motor trigeminal nucleus

MPA:

Medial preoptic area

MPo:

Medial preoptic nucleus

MS:

Medial septal nucleus

n3:

Oculomotor nucleus

n6:

Abducens nucleus

n7:

Facial nucleus

n10:

Dorsal motor nucleus, vagus

n11:

Nucleus of the lateral lemniscus

n12:

Hypoglossal nucleus

opt:

Optic tract

ox:

Optic chiasm

Pa:

Paraventricular hypothalamic nucleus

Pb:

Parabrachial nuclei

Pe:

Periventricular hypothalamic nucleus

PF:

Parafascicular thalamic nucleus

PM:

Premammillary nucleus

PMCo:

Posteromedial cortical amygdaloid nucleus (C3)

PMR:

Paramedian raphe nucleus

Pn1:

Pontine nucleus

PnC:

Pontine reticular nucleus, caudal part

PnO:

Pontine reticular nucleus, oral part

Po:

Primary olfactory cortex

Pr5:

Principal sensory trigeminal nucleus

PVA:

Paraventricular thalamic nucleus, anterior part

PVP:

Paraventricular thalamic nucleus, posterior part

pyr:

Pyramidal tract

R:

Red nucleus

Re:

Reuniens thalamic nucleus

Rh:

Rhomboid thalamic nucleus

RMg:

Raphe magnus nucleus

Rob:

Raphe obscurus nucleus

RPa:

Raphe pallidus nucleus

RPn:

Raphe pontis nucleus

Rr:

Retrorubral nucleus

RRf:

Retrorubral field

Rt:

Reticular thalamic nucleus

RtTg:

Reticulotegmental nucleus, pons

s5:

Sensory root of the trigeminal nerve

SC:

Superior colliculus

scp:

Superior cerebellar peduncle

SFi:

Septofimbrial nucleus

SFO:

Subfornical organ

SHi:

Septohippocampal nucleus

SHy:

Septohypothalamic nucleus

sm:

Stria medullaris of the thalamus

SO:

Superior olivary nucleus

So1:

Nucleus of the solitary tract

SON:

Supraoptic nucleus

Sp5:

Spinal trigeminal tract

Sp5C:

Spinal trigeminal nucleus, caudal part

SPF:

Subparafascicular thalamic nucleus

st:

Stria terminalis

STh:

Subthalamic nucleus

StHy:

Striohypothalamic nucleus

Su3:

Supraoculomotor central gray

SuG:

Superficial gray layer, superior colliculus

TS:

Triangular septal nucleus

Tu:

Olfactory tubercule

Tz:

Nucleus of the trapezoid body

tz:

Trapezoid body

VCo:

Ventral cochlear nucleus

VDB:

Nucleus of the vertical limb of the diagonal band

VL:

Ventrolateral thalamic nucleus

VMH:

Ventromedial hypothalamic nucleus

VP:

Ventral pallidum

VPL:

Ventral posterolateral thalamic nucleus

vtgx:

Ventral tegmental decussation

xscp:

Decussation of the superior cerebellar peduncle

ZI:

Zona incerta

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    Patrick M. Sexton

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Sexton, P.M. Central nervous system binding sites for calcitonin and calcitonin gene-related peptide. Mol Neurobiol 5, 251–273 (1991). https://doi.org/10.1007/BF02935550

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