Skip to main content
Log in

Antioxidant and memory enhancing effects of purple sweet potato anthocyanin and cordyceps mushroom extract

  • Research Articles
  • Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

The effects of purple sweet potato anthocyanin (SPA) and Cordyceps mushroom extract (CME) on lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and cognitive deficits were examined. Both SPA and CME exhibited DPPH radical scavenging activities with similar potency. In contrast, only SPA was shown to effectively inhibit lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Furthermore, SPA markedly enhanced cognitive performance, assessed by passive avoidance test in ethanol-treated mice. Combined treatments with SPA and CME did not significantly influence the effects of SPA alone. These results demonstrate that anthocyanin prepared from purple sweet potato exhibits memory enhancing effects, which may be associated with its antioxidant properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Amouretti, M., Therapeutic value ofVaccinium myrtillus anthocyanosides in an internal medicine department.Therapeutique, 48, 579–581 (1972).

    PubMed  CAS  Google Scholar 

  • Blois, M. S., Antioxidant determination by the use of a stable free radical.Nature, 181, 1199–1200 (1958).

    Article  CAS  Google Scholar 

  • Brewer, G. J., Age-related toxicity to lactate, glutamate, and β-amyloid in cultured adult neurons.Neurobiol. Aging, 19, 561–568 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Coyle, J. T. and Puttfarken, P., Oxidative stress, glutamate, and neurodegenerative disorders.Science, 262, 689–695 (1993)

    Article  PubMed  CAS  Google Scholar 

  • Goda, Y., Shimizu, T., Kato, Y., Nakamura, M., Maitani, T., Yamada, T., Terahara, N., and Yamaguchi, M., Two acylated anthocyanins from purple sweet potato.Phytochem., 44, 183–186 (1997).

    Article  CAS  Google Scholar 

  • Jayle, G. E., Aubry, M., Gavini, H., Braccini, G., and De la Baume, C, Study concerning the action of anthocyanoside extracts of Vaccinium Myrtillus on night vision.Ann. Ocul., 198, 556–562 (1965).

    CAS  Google Scholar 

  • Jianzhe, Y, Xiaolan, M., Quiming, M., Yichen, Z., and Huaan, W., Icons of medicinal fungi from China. Science Press, Beijing, China, pp. 12–23 (1987).

    Google Scholar 

  • Jo, A., Sawai, Y, and Kakuo, H., Food ingredients from purple sweet potato improving the blood circulation.Japanese patent, 2001–145471 (2001).

  • Lazze, M. C., Pizzala, R., Savio, M., Stivala, L. A., Prosperi, E., and Bianchi, L., Anthocyanins protect against DNA damage induced byterf-butylhydroperoxide in rat smooth muscle and hepatoma cells.Mutation Res., 535, 103–115 (2003).

    PubMed  CAS  Google Scholar 

  • Lee, S. C., You, K. H., and Kim, E. B., The functional role of limbic system on memory; Behavioral and neurochemical alterations following acute administration of ethanol in rats.J. Pharm.Sci., 11, 1–10 (1995).

    Google Scholar 

  • Liu, F. and Ng, T B., Antioxidative and free radical scavenging activities of selected medicinal herbes.Life Sci., 66, 725–735 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Ng, T B., Liu, F., and Wang, Z. T., Antioxidative activity of natural products from plants.Life Sci., 66, 709–723 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Odake, K., Terahara, N., Saito, N., Toki, K., and Honda, T., Chemical structures of two abthocyanins from purple sweet potato,Ipomoea batatas.Phytochem., 31, 2127–2130 (1992).

    Article  CAS  Google Scholar 

  • Raghavendra, V. and Kulkarni, S. K., Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks.Free Rad. Biol. Med., 30, 595–602 (2001).

    Article  PubMed  CAS  Google Scholar 

  • Ramirez-Tortosa, C, Anderson, O. M., Gardner, P. T, Morrice, P. C., Wood, S. G., Duthie, S. J., Collins, A. R., and Duthie, G. G., Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in Vitamin E-depleted rats.Free Rad. Biol. Med., 31, 1033–1037 (2001).

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez-Saona, L. E., Wroistad, R. E., and Pereira, C., Glycoalkaloid content and anthocyanin stability to alkaline treatment of red-fleshed potato extracts.J. Food Science, 64, 445–450 (1999).

    Article  CAS  Google Scholar 

  • Shafiee, M., Carbonneau, M. A., d’Huart, J. B., Descomps, B., and Leger, C. L., Synergistic antioxidative properties of phenolics from natural origin toward low-density lipoproteins depend on the oxidation system.J. Med. Food, 5, 69–78 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Sohal, R. S., Arnold, L. A., and Sohal, B. H., Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species.Free Radic. Biol. Med., 9, 495–500 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Sterling, M., Got anthocyanins?Nutrition Science News, December Issue (2001).

  • Sung, J. M., The insect-born fungus of Korea in color. Kyo-Hak Pub. Co., Seoul, Korea (1996).

    Google Scholar 

  • Tanizawa, H., Ohkawa, Y., Takino, Y., Miyase, T, Ueno, A., Kageyama, T, and Hara, S., Studies on natural antioxidants in citrus species. I. Determination of antioxidative activities of citrus fruits.Chem. Pharm. Bull., 40, 1940–1942 (1992).

    PubMed  CAS  Google Scholar 

  • Tsuda, T., Shiga, K., Ohshima, K., Kawakishi, S., and Osawa, T., Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated fromPhaseolus vulgaris L.Biochem. Pharmacol., 52, 1033–1039 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Tsuda, T., Kato, Y., and Osawa, T., Mechanism for the peroxynitrite scavenging activity by anthocyanins.FEBS Lett., 484, 207–210 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Wang, C. J., Wang, J. M., Lin, W. L., Chu, C. Y., Chou, F. P., and Tseng, T. H., Protective effects ofHibiscus anthocyanins againsttert-butylhydroperoxide-induced hepatotoxicity in rats.Food Chem. Toxicol., 38, 411–416 (2000).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kyeong-Soo Chung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cho, J., Kang, J.S., Long, P.H. et al. Antioxidant and memory enhancing effects of purple sweet potato anthocyanin and cordyceps mushroom extract. Arch Pharm Res 26, 821–825 (2003). https://doi.org/10.1007/BF02980027

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02980027

Key words

Navigation