Abstract
To assess cardiac sympathetic nervous function in diabetics, the heart rates attained following a pharmacological dose of intravenous atropine, 23 μg · kg−1, were studied under N2O, isoflurane anaesthesia in diabetics (n = 21) and nondiabetics (n = 30). Atropine-induced heart rate in diabetics was significantly lower than that in nondiabetics (95 ± 14 (SD) bpm vs 109 ±12 bpm, P < 0.001) and were closely related to preoperative orthostatic diastolic blood pressure change (r = 0.60, P < 0.01). There was some correlation between the atropine-induced heart rate and preoperative RR-variation in diabetics (r = 0.50, P < 0.05). The findings suggest that cardiac sympathetic function may also be impaired in diabetics with orthostatic hypotension.
Résumé
Afin d’évaluer la fonction du système nerveux sympathique cardiaque chez les diabétiques, la fréquence cardiaque obtenue après une dose pharmacologique intraveineuse d’atropine, 23 μg · kg−1, a été étudiée sous une anesthésie avec le protoxyde d’azote/oxygène/isoflurane chez des diabétiques (n = 21) et des non-diabétiques (n = 30). La fréquence cardiaque induite par l’atropine a été significativement plus basse que celle obtenue chez les non-diabétiques (95 ± 14 (SD) bpm vs 109 ± 12 bpm, P < 0,001) et ceci était étroitement corrélé avec les changements de la pression artérielle diastolique en période préopératoire et en position osthostatique (r = 0,60, P < 0.01). Il y avait une certaine corrélation entre la fréquence cardiaque induite par l’atropine et les variations RR en période préopératoire chez les diabétiques (r = 0,50, P < 0.05). Ceci suggère que la fonction sympathique cardiaque peut aussi être altérée chez les diabétiques présentant de l’hypotension orthostatique.
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Tsueda, K., Huang, K.C., Dumont, S.W. et al. Cardiac sympathetic tone in anaesthetized diabetics. Can J Anaesth 38, 20–23 (1991). https://doi.org/10.1007/BF03009158
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DOI: https://doi.org/10.1007/BF03009158