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American Journal of Cardiovascular Drugs

Erschienen in:

01.12.2012 | Review Article

Clopidogrel

The Data, the Experience, and the Controversies

verfasst von: Dr Saihari Sadanandan, Inder M. Singh

Erschienen in: American Journal of Cardiovascular Drugs | Ausgabe 6/2012

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Abstract

Dual antiplatelet therapy with acetylsalicylic acid (aspirin) and clopidogrel is a guideline-recommended standard of care for patients with acute coronary syndromes (ACS) and those who undergo percutaneous coronary intervention (PCI). Despite a large body of clinical evidence obtained from randomized clinical trials and patient registries supporting the efficacy and safety of aspirin plus clopidogrel therapy in these patients, questions concerning the optimal use of dual antiplatelet therapy remain. Widely debated topics pertaining to dual antiplatelet therapy in patients with ACS or undergoing PCI include (i) the appropriate clopidogrel loading dose; (ii) the optimal time to initiate the clopidogrel loading dose; (iii) the optimal duration of dual antiplatelet therapy following ACS or PCI; (iv) impact of variability of platelet response on patient outcomes; and (v) the role of other recommended and emerging P2Y₁₂ antagonists. This review discusses these ongoing controversies regarding the optimal use of dual antiplatelet therapy with aspirin and clopidogrel in patients with ACS or those undergoing PCI.

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Titel: Clopidogrel
The Data, the Experience, and the Controversies
verfasst von: Dr Saihari Sadanandan
Inder M. Singh
Publikationsdatum: 01.12.2012
Verlag: Springer International Publishing
Erschienen in: American Journal of Cardiovascular Drugs / Ausgabe 6/2012
Print ISSN: 1175-3277
Elektronische ISSN: 1179-187X
DOI: https://doi.org/10.1007/BF03262471

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Springer Medizin

Clopidogrel

The Data, the Experience, and the Controversies

Abstract

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Abstract

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