Skip to main content
SpringerLink
Log in

Daily hunger sensation and body compartments: II. Their relationships in obese patients

  • Original Research Paper
  • Published:
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Hunger sensation (HS) is a signal whose levels change during the 24-h day. The daily mean level of HS was correlated with the human body compartments, as investigated by bioelectrical impedance analysis, to detect the relationship between the orectic perception and both the free fat mass (FFM) and the fat body mass (FBM) in 22 clinically healthy subjects (CHS) (2 M, 20 W, BMI: 18.5–24.0 kg/m2) and 48 obese patients (OP) (4 M, 44 W, BMI: 25.2–54.7 kg/m2). In CHS, the daily mean level of HS correlated positively with the FFM and negatively with the FBM. These correlations were not present in OP. This lack of relationships between HS and the body compartments where energy is maximally consumed (i.e., the FFM) and maximally stored (i.e., the FBM) indicates that the orectic response to energy expenditure and the orectic inhibition to fat accumulation are feedback mechanisms which are impaired in obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Heini A.F., Lara-Castro C., Kirk K.A., Considine R.V., Caro J.F., Weinsier R.L.: Association of leptin and hunger-satiety ratings in obese women. Int. J. Obes. Relat. Disord., 22, 1084–1087, 1998.

    Article  CAS  Google Scholar 

  2. Joannic J.L., Oppert J.M., Lahlou N., Basdevant A., Auboiron S., Raison J., Bornet F., Guy-Grand B.: Plasma leptin and hunger ratings in healthy humans. Appetite, 30, 129–138, 1998.

    Article  CAS  PubMed  Google Scholar 

  3. Karydis I., Tolis G.: Orexis, anorexia, and thyrotropin-releasing hormone. Thyroid, 8, 947–950, 1998.

    Article  CAS  PubMed  Google Scholar 

  4. Flynn M.C., Scott T.R., Pritchard T.C., Plata-Salaman C.R.: Mode of action of OB protein (leptin) on feeding. Am. J. Physiol., 275, R 174–179, 1998.

    CAS  Google Scholar 

  5. Matson C.A., Wiater M.F., Kuijper J.L., Weigle D.S.: Synergy between leptin and colecystokinin (CCK) to control daily caloric intake. Peptides, 18, 1275–1278, 1998.

    Article  Google Scholar 

  6. Barrachina M.D., Martinez V., Wang L., Wei J.Y., Tache Y.: Synergistic interaction between leptin and cholecystokinin to reduce shortterm food intake in lean mice. Proc. Natl. Acad. Sci. USA, 94, 10455–10460, 1997.

    Article  CAS  PubMed  Google Scholar 

  7. Ormset O.A., Nicolson M., Pelleymounter M.A., Boyer B.B.: Leptin inhibits prehibernation hyperphagia and reduces body weight in Arctic ground squirrels. Am. J. Physiol., 271, R 1775–1779, 1996.

    Google Scholar 

  8. Holst J.J.: Leptin, a new weight loss agent? Nord. Med., 111, 300–303, 1996.

    CAS  PubMed  Google Scholar 

  9. Chudek J., Kokot F.: Leptin satiety hormone? Pol. Arch. Med. Wewn., 95, 397–401, 1996.

    CAS  PubMed  Google Scholar 

  10. Fruhbeck G., Jebb S.A., Prentice A.M.: Leptin: physiology and pathophysiology. Clin. Physiol., 18, 399–419, 1998.

    Article  CAS  PubMed  Google Scholar 

  11. Haffner S.M., Mykkanen L.A., Gonzalez C.C., Stern M.P.: Leptin concentrations do not predict weight gain: the Mexico City Diabetes Study. Int. J. Obes. Relat. Metab. Disord., 22, 695–699, 1998.

    Article  CAS  PubMed  Google Scholar 

  12. Harrold J.A., Cai X., Williams G.: Leptin, the hypothalamus and the regulation of adiposity. Curr. Opin. Lipidol., 9, 295–299, 1998.

    Article  CAS  PubMed  Google Scholar 

  13. Barinaga M.: “Obese” protein slims mice. Science, 269, 475–476, 1995.

    Article  CAS  PubMed  Google Scholar 

  14. Lonnqvist F., Wennlund A., Arner P.: Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int. J. Obes. Relat. Metab. Disord., 21, 255–260, 1997.

    Article  CAS  PubMed  Google Scholar 

  15. Ronnemaa T., Karonen S.L., Rissanen A., Koskenvuo M., Koivisto V.A.: Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity. Ann. Intern. Med., 126, 26–31, 1997.

    Article  CAS  PubMed  Google Scholar 

  16. Hickey M.S., Considine R.V., Israel R.G., Mahar T.L., McCammon M.R., Tyndall G.L., Houmard J.A., Caro J.F.: Leptin is related to body fat content in male distance runners. Am. J. Physiol., 271, E 938–940, 1996.

    CAS  Google Scholar 

  17. Butler M.G., Hedges L., Hovis C.L., Feurer I.D.: Genetic variants of the human obesity (OB) gene in subjects with and without Prader-Willy syndrome: comparison with body mass index and weight. Clin. Genet., 54, 385–393, 1998.

    Article  CAS  PubMed  Google Scholar 

  18. Campostano A., Grillo G., Bessarione D., De Grandi R., Adami G.F.: Relationship of serum leptin to body composition and resting energy expenditure. Horm. Metab. Res., 30, 646–647, 1998.

    Article  CAS  PubMed  Google Scholar 

  19. Thomas B.J., Ward L.C., Cornish B.H.: Bioimpedance spectrometry in the determination of body water compartments: accuracy and clinical significance. Appl. Radiat. Isot., 49, 447–455, 1998.

    Article  CAS  PubMed  Google Scholar 

  20. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med., 334, 292–295, 1996.

    Article  CAS  PubMed  Google Scholar 

  21. Johannsson G., Karlsson C., Lonn L., Marin P., Bjorntorp P., Sjostrom L., Carlsson B., Carlsson L.M., Bengtsson B.A.: Serum leptin concentration and insulin sensitivity in men with abdominal obesity. Obes. Res., 6, 416–421, 1998.

    Article  CAS  PubMed  Google Scholar 

  22. Hamann A., Matthaei S.: Regulation of energy balance by leptin. Exp. Clin. Endocrinol. Diabetes, 104, 293–300, 1996.

    Article  CAS  PubMed  Google Scholar 

  23. Cugini P., Battisti P., Di Palma L.: Eating behaviour: investigation on the recursive components of hunger sensation by iterative rhythmometry. Ital. J. Gastroenterol., 23, 128–131, 1991.

    CAS  PubMed  Google Scholar 

  24. Cugini P., Battisti P., Paggi A., Di Stasio E.M., Di Palma L., Morelli F., Pisculli M., Lavielle R.: Chronobiometric identification of disorders of hunger sensation in essential obesity: therapeutic effects of dexfenfluramine. Metabolism, 44, 50–56, 1995.

    Article  CAS  PubMed  Google Scholar 

  25. Cugini P., Battisti P., Di Palma L., Ferrari E.: Spectral analysis to explore hunger sensation in obesity. Chronobiological Section, 1, 36–44, 1994.

    Google Scholar 

  26. Cugini P., Murano G., Lucia P., Letizia C., Mazzetti di Pietralata M.: Circadian and ultradian rhythms for hunger behaviour. In: Ferrari E., Brambilla F. (Eds.) Disorders of Eating Behaviour. A Psychoneuroendocrine Approach. Adv. Biosci. Vol 60. Oxford, Pergamon Press, 1986, pp. 93–96.

    Google Scholar 

  27. Cugini P., Battisti P., Di Palma L.: Analisi spettrale per il riscontro diagnostico ed il controllo delle anomalie della sensazione di fame. In: Mazzetti di Pietralata M. (Ed.) Proceedings of the Congress on “Aspetti Clinici e Psicologici del Comportamento Alimentare”. Roma, Istituto Poligrafico e della Zecca dello Stato, 1991, pp. 44–78.

    Google Scholar 

  28. van Kreel B.K., Cox-Reyven N., Soeters P.: Determination of total body water by multifrequency bio-electric impedance: development of several models. Med. Biol. Eng. Comput., 51, 337–345, 1998.

    Article  Google Scholar 

  29. Heyward V.H.: Practical body composition assessment for children, adults, and older adults. Int. J. Sport Nutr., 8, 285–307, 1998.

    CAS  PubMed  Google Scholar 

  30. Matthie J.R., Withers P.O.: Bioimpedance: 50 kHz parallel reactance and the prediction of body cell mass. Am. J. Clin. Nutr., 68, 403–404, 1998.

    CAS  PubMed  Google Scholar 

  31. Van Load M.D.: Extimates of fat-free mass (FFM) by densitometry, dual energy X-ray absorptiometry (DXA), and bioimpedance spectroscopy (BIS) in caucasian and Chinese-American women. Appl. Radiat. Isot., 49, 751–752, 1998.

    Article  Google Scholar 

  32. Stroud D.B., Cornish B.H., Thomas B.J., Ward L.C.: A comparison of two multi-frequency bioimpedance analysers. Appl. Radiat. Isot., 49, 479–480, 1998.

    Article  CAS  PubMed  Google Scholar 

  33. Sahu A.: Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology, 139, 4739–4742, 1998.

    Article  CAS  PubMed  Google Scholar 

  34. de Lorenzo A, Sorge S.P., Iacopino L., Andreoli A., de Luca P.P., Sasso G.F.: Fatfree mass by bioelectrical impedance vs dual-energy X-ray absorptiometry (DXA). Appl. Radiat. Isot., 49, 739–741, 1998.

    Article  PubMed  Google Scholar 

  35. Vache C., Rousset P., Gachon P., Gachon A.M., Morio B., Boulier A., Coudert J., Beaufrere B., Ritz P.: Bioelectrical impedance analysis measurements of total body water in healthy elderly subjects. Int. J. Relat. Metab. Disord., 22, 537–543, 1998.

    Article  CAS  Google Scholar 

  36. Bussolotto M., Ceccon A., Sergi G., Giantin V., Beninc P., Enzi G.: Assessment of body composition in elderly: Accuracy of Bioelectrical Impedance Analysis. Gerontology, 45, 39–43, 1999.

    Article  CAS  PubMed  Google Scholar 

  37. Jakicic J.M., Wing R.R., Lang W.: Bioelectrical impedance analysis to assess body composition in obese adult women: the effect of ethnicity. Int. J. Obes. Relat. Metab. Disord., 22, 243–249, 1998.

    Article  CAS  PubMed  Google Scholar 

  38. Tsui E.Y., Gao X.J., Zinman B.: Bioelectrical Impedance Analysis (BIA) using bipolar foot electrodes in the assessment of body composition in Type 2 diabetes mellitus. Diabet. Med., 15, 125–128, 1998.

    Article  CAS  PubMed  Google Scholar 

  39. Rutter K., Hennoste L., Ward L.C., Cornish B.H., Thomas B.J.: Bioelectrical impedance analysis for the estimation of body composition in rats. Lab. Anim., 32, 65–71, 1998.

    Article  CAS  PubMed  Google Scholar 

  40. Prichard C., Kyle U.G., Gremion G., Gerbase M., Slosman D.O.: Body composition by X-ray absorptiometry and bioelectrical impedance in female runners. Med. Sci. Sports Exerc., 29, 1527–1534, 1997.

    Article  Google Scholar 

  41. Hildreth H.G., Johnson R.K., Goran M.I., Contompasis S.H.: Body composition in adults with cerebral palsy by dual-energy X-Ray absorptiometry, bioelectrical impedance analysis, and skinfold anthropometry compared with the 180 isotope-dilution technique. Am. J. Clin. Nutr., 66, 1435–1442, 1997.

    Google Scholar 

  42. Wagner D.R., Heyward V.H., Kocina P.S., Stolarczyk L.M., Wilson W.L.: Predictive accuracy of BIA equations for estimating fat-free mass of black men. Med. Sci. Sports Exerc., 29, 969–974, 1997.

    Article  CAS  PubMed  Google Scholar 

  43. Eckerson J.M., Evetovich T.K., Stout J.R., Housh T.J., Johnson G.O., Housh D.J., Ebersole K.T., Smith D.B.: Validity of bioelectrical impedance analysis equations for estimating fat-free mass weight in high school female gymnast. Med. Sci. Sports Exerc., 29, 962–968, 1997.

    Article  CAS  PubMed  Google Scholar 

  44. Ainsworth B.E., Stolarczyk L.M., Heyward V.H., Berry C.B., Irwin M.L., Mussulman L.M.: Predictive accuracy of bioimpedance in estimating fat-free mass of African-American women. Med. Sci. Sports Exerc., 29, 781–787, 1997.

    Article  CAS  PubMed  Google Scholar 

  45. Carella M.J., Rodgers C.D., Anderson D., Gossain V.V.: Serial measurements of body composition in obese subjects during a very-low-energy diet (VLED) comparing bioelectrical impedance with hydrodensitometry. Obes. Res., 5, 250–256, 1997.

    Article  CAS  PubMed  Google Scholar 

  46. Cugini P., Salandri A., Petrangeli C.M., Capodaglio P.F., Giovannini C.: Circadian rhythms in human body composition. Chronobiol. Int., 13, 359–371, 1996.

    Article  CAS  PubMed  Google Scholar 

  47. Heyward V.H.: Evaluation of body composition. Current issues Sport Med., 22, 146–156, 1996.

    CAS  Google Scholar 

  48. Houtkooper L.B., Lohman T.G., Going S.B., Howell V.H.: Why bioelectrical impedance analysis should be used for estimating adiposity. Am. J. Clin. Nutr., 64, 436S–448S, 1996.

    CAS  PubMed  Google Scholar 

  49. Roubenoff R.: Applications of bioelectrical impedance analysis for body composition to epidemiologic studies. Am. J. Clin. Nutr., 64, 459S–462S, 1996.

    CAS  PubMed  Google Scholar 

  50. Fogelholm G.M., Kukkonen-Harjula T.K., Sievanen H.T., Oja P., Vuori I.M.: Body composition assessment in lean and normalweight young women. Br. J. Nutr., 75, 793–802, 1996.

    Article  CAS  PubMed  Google Scholar 

  51. Hu H.Y., Kato Y.: Body composition assessed by bioelectrical impedance analysis (BIA) in patients with Graves’ disease before and after treatment. Endocrinol. J., 42, 545–550, 1995.

    CAS  Google Scholar 

  52. Lukaski H.C.: Methods for the assessment of human body composition: traditional and new. Am. J. Clin. Nutr., 46, 537–556, 1987.

    CAS  PubMed  Google Scholar 

  53. Kushner R.F., Shoeller D.A.: Estimation of total body water by bioelectrical impedance analysis. Am. J. Clin. Nutr., 44, 417–424, 1986.

    CAS  PubMed  Google Scholar 

  54. Kushner F.R., Hass A.: Estimation of lean body mass by bioelectrical impedance analysis compared to skinfold anthropometry. Eur. J. Clin. Nutr., 42, 101–106, 1988.

    CAS  PubMed  Google Scholar 

  55. Kushner R.F., Kunig K.A., Alspaugh M., Andronis P.T., Leitch C.A., Schoeller D.A.: Validation of bioelectrical impedance analysis as a measurement of changes in body composition in obesity. Am. J. Clin. Nutr., 52, 219–223, 1990.

    CAS  PubMed  Google Scholar 

  56. Lukaski H.C.: Bioelectrical impedance analysis. Am. J. Clin. Nutr. 41, 810–817, 1985.

    CAS  PubMed  Google Scholar 

  57. Lukaski H.C., Johnson P.E., Bolonchiuk W.W., Lykken G.I.: Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am. J. Clin. Nutr., 41, 810–817, 1985.

    CAS  PubMed  Google Scholar 

  58. Lukaski H.C., Bolonchiuk W.W., Hall C.B., Siders W.A.: Validation of tetrapolar bioelectrical impedance method to assess human body composition. J. Appl. Physiol., 60, 1322–1327, 1986.

    Google Scholar 

  59. Van Loan N., Mayclin P.: Bioelectrical Impedance Analysis: is it a reliable estimator of lean body mass and total body water? Hum. Biol., 59, 299–309, 1987.

    PubMed  Google Scholar 

  60. Segal K.R., Gutin B., Prest A.E., Wang J., Van Itallie T.B.: Estimation of human body composition. J. Appl. Physiol., 58, 1565–1571, 1985.

    CAS  PubMed  Google Scholar 

  61. Segal K.R., Van Loan M., Fitzgerald P.I., Hodgdon J.A., Van Itallie T.B.: Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am. J. Clin. Nutr., 47, 7–14, 1988.

    CAS  PubMed  Google Scholar 

  62. Deuremberg P., Westrate J.A., Van der Kooy K.: Body composition changes assessed by bioelectrical impedance measurements. Am. J. Clin. Nutr., 49, 401–403, 1989.

    Google Scholar 

  63. Deuremberg P., Kooy K., Leenen R., Weststrate J.A., Seidell J.C.: Sex and age specific prediction formulas for estimating body composition from bioelectrical impedance: a cross-validation study. Int. J. Obes., 15, 17–25, 1991.

    Google Scholar 

  64. Deuremberg P.: Limitations of the bioelectrical impedance method for the assessment of body fat in severe obesity. Am. J. Clin. Nutr., 64 (Suppl), 449S–452S, 1996.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di II Clinica Medica, University of Rome “La Sapienza”, Vilae del Policlinico 155, 00161, Roma, Italy

    Pietro Cugini, A. Salandri, M. Cilli, P. Ceccotti, A. Di Marzo, A. Rodio, S. Fontana, A. M. Pellegrino, G. P. De Francesco, S. Coda, F. De Vito, L. Colosi, C. M. Petrangeli & C. Giovannini

Authors
  1. Pietro Cugini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Salandri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Cilli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Ceccotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Di Marzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Rodio
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. Fontana
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. M. Pellegrino
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. G. P. De Francesco
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. S. Coda
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. F. De Vito
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. L. Colosi
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. C. M. Petrangeli
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. C. Giovannini
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cugini, P., Salandri, A., Cilli, M. et al. Daily hunger sensation and body compartments: II. Their relationships in obese patients. Eat Weight Disord 4, 81–88 (1999). https://doi.org/10.1007/BF03339722

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03339722

Key words

Search

Navigation