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Effects of isoprinosine onEchinococcus multilocularis andE. granulosus metacestodes

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Abstract

An in vivo study of the effect of Isoprinosine onEchinococcus multilocularis andE. granulosus metacestodes (Cestoda) was performed. Short- and longterm treatments with different doses were tested in experimental hosts: jirds forE. multilocularis and mice forE. granulosus. Modifications in the weight of animals as well as macroscopical and ultrastructural aspects were registered for each animal group. The results obtained showed a considerable ultrastructural alteration inE. multilocularis metacestodes after short-term treatment with the highest dose, and the tissue transplants were negative. InE. granulosus cysts the ultrastructural damage was also very important and its severity increased as the dose was raised. For the two parasites, the macroscopical aspect and weight of the lesions were profoundly changed.

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Authors and Affiliations

  1. Department of Parasitology and Medical Mycology, Claude-Bernard University, 8 avenue Rockefeller, F-69 373, Lyon Cedex 08, France

    M. Elisabeth Sarciron, Suzanne Walbaum & A. Françoise Petavy

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  1. M. Elisabeth Sarciron
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  2. Suzanne Walbaum
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  3. A. Françoise Petavy
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Elisabeth Sarciron, M., Walbaum, S. & Petavy, A.F. Effects of isoprinosine onEchinococcus multilocularis andE. granulosus metacestodes. Parasitol Res 81, 329–333 (1995). https://doi.org/10.1007/BF00931540

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  • DOI: https://doi.org/10.1007/BF00931540

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