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Lobular Breast Cancer: Pathology, Biology, and Options for Clinical Intervention

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  • Published:
Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Lobular carcinoma is a breast cancer subtype comprising approximately 15 % of all breast cancer cases. Clinical diagnosis of this subtype is difficult due to a characteristic growth pattern that inhibits detection using palpation or standard X-ray mammography. While clinical intervention based on hormone antagonists has proven an effective strategy, hormone receptor negative or nonresponsive disease cannot be treated successfully, indicating the need for alternative curative approaches. In contrast to its well-defined histopathological characteristics that were first recognized a century ago, the surface of the underlying biology has only recently been scratched. Progress was made in understanding the biology of the disease, which will hopefully have its impact on future treatment modalities and initiate development of novel intervention strategies. Here, we review the pathological and molecular features of lobular breast cancer and report on the currently known mechanisms that control disease development and progression. Finally we will reflect on past, present, and future treatment options.

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Abbreviations

AJ:

Adherence junction

ALH:

Atypical lobular hyperplasia

DCIS:

Ductal carcinoma in situ

EGFR:

Epidermal growth factor receptor

ER:

Estrogen receptor

IDC:

Invasive ductal carcinoma

LCIS:

Lobular carcinoma in situ

LN:

Lobular neoplasia

ILC:

Invasive lobular carcinoma

p120:

p120-catenin

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Authors and Affiliations

  1. Department of Pathology H04.312, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands

    Eva Vlug, Cigdem Ercan, Paul J. van Diest & Patrick W. B. Derksen

  2. Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands

    Elsken van der Wall

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  1. Eva Vlug
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  2. Cigdem Ercan
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  3. Elsken van der Wall
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  4. Paul J. van Diest
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  5. Patrick W. B. Derksen
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Correspondence to Patrick W. B. Derksen.

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Vlug, E., Ercan, C., van der Wall, E. et al. Lobular Breast Cancer: Pathology, Biology, and Options for Clinical Intervention. Arch. Immunol. Ther. Exp. 62, 7–21 (2014). https://doi.org/10.1007/s00005-013-0251-0

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