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Gatekeepers of intestinal inflammation

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Abstract

The intestine is subjected to a barrage of insults from food, bacterial flora, and pathogens. Despite this constant antigenic challenge, the mucosal tissues lining the intestinal tract remain largely under control. The mechanisms regulating the homeostatic balance in the gut have been investigated for many years by many groups, but the precise nature of the regulatory control remains elusive. In this review, we provide an overview of pathways proposed to be involved in dampening the inflammatory response and maintaining the homeostatic balance in the intestine, and how these pathways may be disrupted in ulcerative colitis and Crohn’s disease.

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Acknowledgments

We thank Ryan Swanson and Janine Bilsborough for their constructive comments and careful reading of the manuscript.

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  1. Inflammation Research, Amgen, 1201 Amgen Court W, Seattle, WA, 98119, USA

    Heather A. Arnett

  2. Inflammation Research, Amgen, One Amgen Center Drive, Thousand Oaks, CA, 91320, USA

    Joanne L. Viney

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Arnett, H.A., Viney, J.L. Gatekeepers of intestinal inflammation. Inflamm. Res. 59, 1–14 (2010). https://doi.org/10.1007/s00011-009-0091-x

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