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Inflammation Research

Erschienen in:

01.11.2010 | Original Research Paper

Serum resistin concentrations in children with Kawasaki disease

verfasst von: Hiroki Nozue, Hironori Imai, Hisako Saitoh, Takeshi Aoki, Kunio Ichikawa, Tomohiro Kamoda

Erschienen in: Inflammation Research | Ausgabe 11/2010

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Abstract

Objective

Human resistin is expressed strongly in monocytes or macrophages rather than in adipocytes and may play a pivotal role in inflammation. We hypothesize that resistin levels are elevated in patients with Kawasaki disease (KD) in the acute phase and may be associated with the disease severity.

Design and subjects

Serum resistin concentrations were measured in 44 Japanese children with KD and 17 age-matched healthy children. All the KD patients were given both aspirin and a single dose of intravenous immunoglobulin (IVIG).

Results

The serum resistin levels at baseline in KD children were significantly higher than those in controls [33.0 (21.6–45.3) vs. 14.8 (12.4–18.6) ng/mL, P < 0.001]. After IVIG therapy, serum resistin levels were significantly decreased to normal control levels. No significant difference in baseline resistin levels was found between the high-risk group and the low-risk group of coronary artery aneurysms.

Conclusions

We confirmed that resistin was an acute inflammatory protein, but its concentrations were unlikely to predict the prognosis of disease in acute KD patients.

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Titel: Serum resistin concentrations in children with Kawasaki disease
verfasst von: Hiroki Nozue
Hironori Imai
Hisako Saitoh
Takeshi Aoki
Kunio Ichikawa
Tomohiro Kamoda
Publikationsdatum: 01.11.2010
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 11/2010
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-010-0202-8

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Serum resistin concentrations in children with Kawasaki disease

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Objective

Design and subjects

Results

Conclusions

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