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01.05.2012 | Original Research Paper

Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

verfasst von: Helen Hermana M. Hermsdorff, Ana Carolina P. Volp, Blanca Puchau, Kiriaque B. F. Barbosa, M. Ángeles Zulet, Josefina Bressan, J. Alfredo Martínez

Erschienen in: Inflammation Research | Ausgabe 5/2012

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Abstract

Objective

This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults.

Methods

Measurements included body composition, lifestyle features, blood biochemical and selected inflammatory markers on 317 healthy subjects [122 males/195 females; 22 ± 3 years; 22.1 ± 2.8 kg/m² (mean ± SD)].

Results

Women had significantly higher CRP and Cp concentrations than men. No gender difference was noted in C3 concentrations. In a multivariate model of the whole sample, body fat (BF), waist circumference (WC) and the sex × WC interaction term presented the highest R ² for variance of CRP (11%), C3 (2%), and Cp (12%), respectively. In regression models separated by sex, BF was the adiposity indicator that explained the variability of CRP in men (13%) and women (7%). WC was the only variable significantly associated with C3 concentrations in women (3%). BF presented the highest partial R ² for Cp in men (8%) and WC in women (16%).

Conclusion

Our findings indicate a relevant interaction between gender and body fat distribution on the variance of CRP, C3, and Cp concentrations in apparently healthy young adults.

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Titel: Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults
verfasst von: Helen Hermana M. Hermsdorff
Ana Carolina P. Volp
Blanca Puchau
Kiriaque B. F. Barbosa
M. Ángeles Zulet
Josefina Bressan
J. Alfredo Martínez
Publikationsdatum: 01.05.2012
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 5/2012
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-011-0429-z

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Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

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Methods

Results

Conclusion

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