Skip to main content

Advertisement

Log in

Entry of herpesviruses into mammalian cells

  • Review
  • Published:
Cellular and Molecular Life Sciences Aims and scope Submit manuscript

Abstract.

The mechanism that herpesviruses use to enter cells is one of the most complex viral entry mechanisms studied so far. This complexity seems to mount as new participants, both cellular receptors and viral glycoproteins, are identified. Recent structural work on entry glycoproteins gD and gB from herpes simplex virus (HSV) 1 has illuminated the functional roles of these glycoproteins in the process of entry. In doing so, it provided information on the mechanism of two critical steps of HSV entry: receptor-mediated activation and membrane fusion. Remarkably, it is becoming clear that herpesviruses have a lot in common with other, simpler viruses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. E. Heldwein.

Additional information

Received 16 December 2007; received after revision 18 January 2008; accepted 25 January 2008

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heldwein, E.E., Krummenacher, C. Entry of herpesviruses into mammalian cells. Cell. Mol. Life Sci. 65, 1653–1668 (2008). https://doi.org/10.1007/s00018-008-7570-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-008-7570-z

Keywords.

Navigation