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B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors

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Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system that sense target cells through a panel of activating and inhibitory receptors. Together with NKG2D, the natural cytotoxicity receptors (NCRs) are major activating receptors involved in tumor cell detection. Although numerous NKG2D ligands have been identified, characterization of the molecules interacting with the NCRs is still incomplete. The identification of B7-H6 as a counter structure of the NCR NKp30 shed light on the molecular basis of NK cell immunosurveillance. We review here the current knowledge on NKp30 and B7-H6, and we discuss their potential role in anti-tumor immunity.

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Authors and Affiliations

  1. Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai Minato-ku, Tokyo, Japan

    Tomonori Kaifu

  2. Centre d’Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, Campus de Luminy, 13288, Marseille, France

    Bertrand Escalière, Eric Vivier & Myriam Baratin

  3. INSERM U631, Case 906, Campus de Luminy, 13288, Marseille, France

    Bertrand Escalière, Eric Vivier & Myriam Baratin

  4. Centre National de la Recherche Scientifique, UMR6102, Case 906, Campus de Luminy, 13288, Marseille, France

    Bertrand Escalière, Eric Vivier & Myriam Baratin

  5. INSERM UMR-S850, Laboratoire de Pharmacologie des Immunosuppresseurs en Transplantation, Faculté de Médecine et de Pharmacie, Université de Limoges, Limoges, France

    Louis N. Gastinel

  6. Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 147 Boulevard Baille, 13385, Marseille, France

    Eric Vivier

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  1. Tomonori Kaifu
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  2. Bertrand Escalière
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Correspondence to Myriam Baratin.

Additional information

Two papers describing NKp30 structures free and complexed with B7-H6 have been published during the preparation of this manuscript.

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Kaifu, T., Escalière, B., Gastinel, L.N. et al. B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors. Cell. Mol. Life Sci. 68, 3531–3539 (2011). https://doi.org/10.1007/s00018-011-0802-7

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