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Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits

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Abstract

Influenza viruses cause acute respiratory infections, which are highly contagious and occur as seasonal epidemic and sporadic pandemic outbreaks. Innate immune response is activated shortly after infection with influenza A viruses (IAV), affording effective protection of the host. However, this response should be tightly regulated, as insufficient inflammation may result in virus escape from immunosurveillance. In contrast, excessive inflammation may result in bystander lung tissue damage, loss of respiratory capacity, and deterioration of the clinical outcome of IAV infections. In this review, we give a comprehensive overview of the innate immune response to IAV infection and summarize the most important findings on how the host can inappropriately respond to influenza.

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Authors and Affiliations

  1. VirPath, EA4610 Virologie et Pathologie Humaine, Faculté de médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, 69008, Lyon, France

    Fatma Berri, Vuong Ba Lê, Bruno Lina & Béatrice Riteau

  2. Inserm, U698, Paris, France

    Martine Jandrot-Perrus

  3. Université Paris 7, Paris, France

    Martine Jandrot-Perrus

  4. AP-HP, Hôpital Xavier Bichat, Paris, France

    Martine Jandrot-Perrus

  5. INRA, Nouzilly, France

    Béatrice Riteau

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  1. Fatma Berri
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Berri, F., Lê, V.B., Jandrot-Perrus, M. et al. Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits. Cell. Mol. Life Sci. 71, 885–898 (2014). https://doi.org/10.1007/s00018-013-1479-x

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