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Viral genes as oncolytic agents for cancer therapy

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Abstract

Many viruses have the ability to modulate the apoptosis, and to accomplish it; viruses encode proteins which specifically interact with the cellular signaling pathways. While some viruses encode proteins, which inhibit the apoptosis or death of the infected cells, there are viruses whose encoded proteins can kill the infected cells by multiple mechanisms, including apoptosis. A particular class of these viruses has specific gene(s) in their genomes which, upon ectopic expression, can kill the tumor cells selectively without affecting the normal cells. These genes and their encoded products have demonstrated great potential to be developed as novel anticancer therapeutic agents which can specifically target and kill the cancer cells leaving the normal cells unharmed. In this review, we will discuss about the viral genes having specific cancer cell killing properties, what is known about their functioning, signaling pathways and their therapeutic applications as anticancer agents.

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Acknowledgments

We apologize to those researchers whose important work we were not able to cite because of space limitations.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, UP, India

    Shishir Kumar Gupta, Ravi Kumar Gandham, A. P. Sahoo & A. K. Tiwari

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  1. Shishir Kumar Gupta
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  2. Ravi Kumar Gandham
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  3. A. P. Sahoo
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  4. A. K. Tiwari
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Correspondence to A. K. Tiwari.

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Gupta, S.K., Gandham, R.K., Sahoo, A.P. et al. Viral genes as oncolytic agents for cancer therapy. Cell. Mol. Life Sci. 72, 1073–1094 (2015). https://doi.org/10.1007/s00018-014-1782-1

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  • DOI: https://doi.org/10.1007/s00018-014-1782-1

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