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Physical and mechanical regulation of macrophage phenotype and function

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Abstract

Macrophages are tissue-resident immune cells that play a critical role in maintaining homeostasis and fighting infection. In addition, these cells are involved in the progression of many pathologies including cancer and atherosclerosis. In response to a variety of microenvironmental stimuli, macrophages can be polarized to achieve a spectrum of functional phenotypes. This review will discuss some emerging evidence in support of macrophage phenotypic regulation by physical and mechanical cues. As alterations in the physical microenvironment often underlie pathophysiological states, an understanding of their effects on macrophage phenotype and function may help provide mechanistic insights into disease pathogenesis.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697, USA

    Frances Y. McWhorter, Chase T. Davis & Wendy F. Liu

  2. Department of Chemical Engineering and Materials Science, University of California Irvine, 916 Engineering Tower, Irvine, CA, 92697, USA

    Wendy F. Liu

  3. The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California Irvine, 2400 Engineering Hall, Irvine, CA, 92697, USA

    Frances Y. McWhorter, Chase T. Davis & Wendy F. Liu

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  1. Frances Y. McWhorter
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Correspondence to Wendy F. Liu.

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McWhorter, F.Y., Davis, C.T. & Liu, W.F. Physical and mechanical regulation of macrophage phenotype and function. Cell. Mol. Life Sci. 72, 1303–1316 (2015). https://doi.org/10.1007/s00018-014-1796-8

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